TSC22D3 and MAD1L1

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		TSC22D3	MAD1L1
Gene Name		TSC22 domain family, member 3	MAD1 mitotic arrest deficient-like 1 (yeast)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytosol	Kinetochore Condensed Chromosome Kinetochore Nucleus Nuclear Pore Cytoplasm Centrosome Spindle Cytosol Actin Cytoskeleton Mitotic Spindle
	Molecular Function	Sequence-specific DNA Binding Transcription Factor Activity MRF Binding	Protein Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Response To Osmotic Stress Body Fluid Secretion Ion Transmembrane Transport Negative Regulation Of Skeletal Muscle Tissue Development Transmembrane Transport Negative Regulation Of Activation-induced Cell Death Of T Cells	Mitotic Cell Cycle Mitotic Nuclear Division Mitotic Cell Cycle Checkpoint Mitotic Spindle Assembly Checkpoint Cell Division Regulation Of Metaphase Plate Congression
Pathways		Ion channel transport Stimuli-sensing channels	Mitotic Spindle Checkpoint Amplification of signal from the kinetochores Mitotic Prometaphase Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Cell Cycle Checkpoints Mitotic Anaphase Mitotic Metaphase and Anaphase Cell Cycle, Mitotic M Phase
Drugs
Diseases
GWAS			Bipolar disorder ( 21926972) Longevity ( 20834067) Schizophrenia ( 22688191) Testicular germ cell tumor ( 23666239)
Protein-Protein Interactions		15 interactors: C19orf57 DCLK2 FOS HPCAL4 JUN MAD1L1 MDM2 MTA2 NFKB1 NFKB2 PLEKHF2 RAF1 RELA SUMO1 TP53	38 interactors: ALOX5 AMOTL2 BAG5 CCDC94 CCHCR1 COIL CWF19L2 FAM131C HAUS1 HDAC1 HDAC2 LGALSL MAD2L1 MAX MFAP1 MLX NDC80 NEBL NEK2 NINL NONO PSMA1 RNF8 SIN3A SIN3B SPATA2 TEX11 TPM1 TPM3 TPR TRIM29 TSC22D3 TSHZ3 TUBGCP4 UBC UBTF USP15 ZSCAN32
Entrez ID		1831	8379
HPRD ID		04266	04065
Ensembl ID		ENSG00000157514	ENSG00000002822
Uniprot IDs		Q5JRJ2 Q99576	B3KR41 Q9Y6D9
PDB IDs			1GO4 4DZO
Enriched GO Terms of Interacting Partners?		Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Fc-epsilon Receptor Signaling Pathway Regulation Of Innate Immune Response Toll-like Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Innate Immune Response Fc Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Immune Response Innate Immune Response-activating Signal Transduction Regulation Of Immune Response Activation Of Innate Immune Response Cellular Response To Growth Factor Stimulus Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Response To Growth Factor Negative Regulation Of Cellular Metabolic Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Innate Immune Response Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Response To Oxidative Stress Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Immune System Process Intracellular Signal Transduction Negative Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Biosynthetic Process Defense Response Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter Immune System Process Positive Regulation Of Cellular Biosynthetic Process Cellular Response To Alkaloid Response To Abiotic Stimulus NIK/NF-kappaB Signaling Response To Cytokine Protein Localization To Nucleus Regulation Of Transcription From RNA Polymerase II Promoter	Negative Regulation Of Gene Expression Mitotic Cell Cycle Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Mitotic Cell Cycle Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Chromosome Organization Cell Cycle Process Negative Regulation Of Biosynthetic Process Cell Cycle Organelle Organization Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Death Histone Deacetylation Protein Deacetylation Negative Regulation Of Ubiquitin-protein Transferase Activity Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression, Epigenetic Mitotic Nuclear Division Regulation Of Ubiquitin-protein Transferase Activity RNA Biosynthetic Process Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Protein Ubiquitination Positive Regulation Of Cell Cycle Process Histone Modification Regulation Of Protein Catabolic Process Regulation Of Cell Cycle Phase Transition Chromatin Modification Regulation Of Apoptotic Process Regulation Of Mitotic Cell Cycle Transcription From RNA Polymerase II Promoter G2/M Transition Of Mitotic Cell Cycle Cell Division Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Proteasomal Protein Catabolic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Cell Death Regulation Of Cell Cycle Regulation Of Proteolysis Negative Regulation Of Cell Cycle Positive Regulation Of Spindle Checkpoint Transcription, DNA-templated Positive Regulation Of Cell Cycle Chromatin Organization
Tagcloud ?		2xglucocorticoid 2xgre agonism agonists beas bronchial budesonide cdkn1c ciclesonide combat dexamethasone dusp1 fluticasone formoterol furoate glucocorticoid glucocorticoids gre gsk9027 gw870086x ikk2 nr3c1 phosphoinositide propionate reporter rgs2 ru24858 suboptimal viii	adverse altered aneuploidy arrest biomarker carcinogenesis characteristic checkpoint checkpoints chromosomal clinicopathological contraindication correlation defects instability mammary microarray mitotic nuclei ones os pacilitaxel predict shorter subtypes taxol undergone whose worse
Tagcloud (Difference) ?		2xglucocorticoid 2xgre agonism agonists beas bronchial budesonide cdkn1c ciclesonide combat dexamethasone dusp1 fluticasone formoterol furoate glucocorticoid glucocorticoids gre gsk9027 gw870086x ikk2 nr3c1 phosphoinositide propionate reporter rgs2 ru24858 suboptimal viii	adverse altered aneuploidy arrest biomarker carcinogenesis characteristic checkpoint checkpoints chromosomal clinicopathological contraindication correlation defects instability mammary microarray mitotic nuclei ones os pacilitaxel predict shorter subtypes taxol undergone whose worse
Tagcloud (Intersection) ?