DR1 and TTF2

Number of citations of the paper that reports this interaction (PMID 12927788)
7

Data Source:
BioGRID (two hybrid)

		DR1	TTF2
Gene Name		down-regulator of transcription 1, TBP-binding (negative cofactor 2)	transcription termination factor, RNA polymerase II
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Ada2/Gcn5/Ada3 Transcription Activator Complex	Spliceosomal Complex Cytoplasm Transcription Elongation Factor Complex
	Molecular Function	DNA Binding Transcription Corepressor Activity Protein Binding Transcription Factor Binding TBP-class Protein Binding Sequence-specific DNA Binding Protein Heterodimerization Activity	DNA Binding Protein Binding ATP Binding ATP-dependent Helicase Activity DNA-dependent ATPase Activity Zinc Ion Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Organization Transcription, DNA-templated Histone H3 Acetylation	DNA-templated Transcription, Termination Regulation Of Transcription, DNA-templated Termination Of RNA Polymerase II Transcription MRNA Processing RNA Splicing
Pathways		Chromatin modifying enzymes Chromatin organization HATs acetylate histones
Drugs
Diseases
GWAS
Protein-Protein Interactions		8 interactors: DRAP1 NFIL3 NFYC POLE3 TBP TTF2 XPO1 ZDHHC17	22 interactors: CDC5L CDKL3 CLPB DCP1A DR1 DRAP1 HINFP HNRNPA1 HNRNPA2B1 KIF4A MATR3 MYB MYBL2 NVL PDCD6IP PRDX4 SKIL SMAD1 SMAD7 TACC3 TNIP1 ZSCAN1
Entrez ID		1810	8458
HPRD ID		03284	05280
Ensembl ID
Uniprot IDs		Q01658 Q658N3	Q9UNY4
PDB IDs		1JFI
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Negative Regulation Of Cellular Metabolic Process DNA-templated Transcription, Termination Transcription, DNA-templated RNA Biosynthetic Process Pharynx Development Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Gene Expression Ribosomal Small Subunit Export From Nucleus Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process RNA Metabolic Process Soft Palate Development Transcription From RNA Polymerase II Promoter Ribosomal Large Subunit Export From Nucleus Nitrogen Compound Metabolic Process Ribosomal Subunit Export From Nucleus Hard Palate Development Chromatin Silencing At RDNA Thyroid Hormone Generation Lipoprotein Transport Magnesium Ion Transport Positive Regulation Of Transcription, DNA-templated Regulation Of Protein Export From Nucleus Termination Of RNA Polymerase I Transcription Thyroid Hormone Metabolic Process Transcription Elongation From RNA Polymerase I Promoter Thyroid Gland Development Intracellular Transport Of Virus Transcription Initiation From RNA Polymerase I Promoter Protein Palmitoylation Positive Regulation Of Macromolecule Biosynthetic Process Transcription From RNA Polymerase I Promoter	Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter RNA Metabolic Process Heterocycle Metabolic Process Transcription, DNA-templated Negative Regulation Of Gene Expression RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Nitrogen Compound Metabolic Process Cell Cycle Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Macromolecule Biosynthetic Process Transcription From RNA Polymerase II Promoter Negative Regulation Of Biosynthetic Process Cell Cycle Regulation Of Cell Cycle Regulation Of Gene Expression Cellular Metabolic Process Mitotic Spindle Assembly Regulation Of Nitrogen Compound Metabolic Process Spindle Organization Negative Regulation Of Cellular Metabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Cell Morphogenesis Involved In Differentiation Positive Regulation Of Dendrite Morphogenesis Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Positive Regulation Of Transcription, DNA-templated Regulation Of Cell Morphogenesis Biosynthetic Process Mitotic Spindle Organization Positive Regulation Of Neuron Projection Development MRNA Metabolic Process MRNA Splicing, Via Spliceosome Negative Regulation Of Male Germ Cell Proliferation Modulation By Symbiont Of Host I-kappaB Kinase/NF-kappaB Cascade Response To Stress RNA Splicing, Via Transesterification Reactions Positive Regulation Of Dendrite Development Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Tagcloud ?		cofactors conferred consensus cos cultured dr1d dr1p dr5 efficiently eighth harbors hcrabpii heterodimers heterologous homology insufficient kc keratinocytes nonfunctional rargamma responsiveness restored retinoid rxralpha share start supershift surprisingly	away bidirectional coimmunoprecipitate cotranscriptional dcp1a dcp2 decapping edc3 elongation ends exonuclease facilitates localize nascent pause paused peaks pol premature productive redistribution seq shifted spt5 termination torpedo tss tsss xrn2
Tagcloud (Difference) ?		cofactors conferred consensus cos cultured dr1d dr1p dr5 efficiently eighth harbors hcrabpii heterodimers heterologous homology insufficient kc keratinocytes nonfunctional rargamma responsiveness restored retinoid rxralpha share start supershift surprisingly	away bidirectional coimmunoprecipitate cotranscriptional dcp1a dcp2 decapping edc3 elongation ends exonuclease facilitates localize nascent pause paused peaks pol premature productive redistribution seq shifted spt5 termination torpedo tss tsss xrn2
Tagcloud (Intersection) ?