DPP4 and CXCL9

Number of citations of the paper that reports this interaction (PMID 11390394)
34

Data Source:
HPRD (in vitro)

		DPP4	CXCL9
Gene Name		dipeptidyl-peptidase 4	chemokine (C-X-C motif) ligand 9
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Lysosomal Membrane Plasma Membrane Focal Adhesion Cell Surface Membrane Integral Component Of Membrane Apical Plasma Membrane Lamellipodium Endocytic Vesicle Lamellipodium Membrane Membrane Raft Intercellular Canaliculus Extracellular Vesicular Exosome Invadopodium Membrane	Extracellular Region Extracellular Space External Side Of Plasma Membrane
	Molecular Function	Protease Binding Serine-type Endopeptidase Activity Receptor Binding Protein Binding Serine-type Peptidase Activity Dipeptidyl-peptidase Activity Identical Protein Binding Protein Homodimerization Activity	Cytokine Activity Protein Binding Chemokine Activity CXCR3 Chemokine Receptor Binding
	Biological Process	Response To Hypoxia Proteolysis Positive Regulation Of Cell Proliferation Negative Regulation Of Extracellular Matrix Disassembly T Cell Costimulation Regulation Of Cell-cell Adhesion Mediated By Integrin T Cell Activation Endothelial Cell Migration	Positive Regulation Of Leukocyte Chemotaxis Chemotaxis Defense Response Inflammatory Response Immune Response Cellular Defense Response Signal Transduction G-protein Coupled Receptor Signaling Pathway Cell-cell Signaling T Cell Chemotaxis Positive Regulation Of CAMP Metabolic Process Response To Lipopolysaccharide Regulation Of Cell Proliferation Positive Regulation Of CAMP-mediated Signaling Positive Regulation Of Myoblast Differentiation Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Defense Response To Virus Chemokine-mediated Signaling Pathway Positive Regulation Of Myoblast Fusion
Pathways		Peptide hormone metabolism Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Incretin synthesis, secretion, and inactivation	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs		Atorvastatin Sitagliptin 2-Amino-3-Methyl-1-Pyrrolidin-1-Yl-Butan-1-One 5-(Aminomethyl)-6-(2,4-Dichlorophenyl)-2-(3,5-Dimethoxyphenyl)Pyrimidin-4-Amine Alpha-D-Mannose (2s)-Pyrrolidin-2-Ylmethylamine Iodo-Phenylalanine Diisopropylphosphono Group 1-(1-phenylcyclopentyl)methylamine (S)-2-[(R)-3-amino-4-(2-fluorophenyl)butyryl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide Vildagliptin Alogliptin Saxagliptin (1S)-2-[(2S,5R)-2-(AMINOMETHYL)-5-PROP-1-YN-1-YLPYRROLIDIN-1-YL]-1-CYCLOPENTYL-2-OXOETHANAMINE N-(TRANS-4-{(1S,2S)-2-AMINO-3-[(3S)-3-FLUOROPYRROLIDIN-1-YL]-1-METHYL-3-OXOPROPYL}CYCLOHEXYL)-N-METHYLACETAMIDE (2S,3S)-4-cyclopropyl-3-{(3R,5R)-3-[2-fluoro-4-(methylsulfonyl)phenyl]-1,2,4-oxadiazolidin-5-yl}-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine (2S,3S)-3-{3-[2-chloro-4-(methylsulfonyl)phenyl]-1,2,4-oxadiazol-5-yl}-1-cyclopentylidene-4-cyclopropyl-1-fluorobutan-2-amine (3R,4R)-4-(pyrrolidin-1-ylcarbonyl)-1-(quinoxalin-2-ylcarbonyl)pyrrolidin-3-amine (7R,8R)-8-(2,4,5-trifluorophenyl)-6,7,8,9-tetrahydroimidazo[1,2-a:4,5-c\']dipyridin-7-amine (2S,3S)-3-{3-[4-(METHYLSULFONYL)PHENYL]-1,2,4-OXADIAZOL-5-YL}-1-OXO-1-PYRROLIDIN-1-YLBUTAN-2-AMINE (1S,2R,5S)-5-[3-(TRIFLUOROMETHYL)-5,6-DIHYDRO[1,2,4]TRIAZOLO[4,3-A]PYRAZIN-7(8H)-YL]-2-(2,4,5-TRIFLUOROPHENYL)CYCLOHEXANAMINE (2R)-4-[(8R)-8-METHYL-2-(TRIFLUOROMETHYL)-5,6-DIHYDRO[1,2,4]TRIAZOLO[1,5-A]PYRAZIN-7(8H)-YL]-4-OXO-1-(2,4,5-TRIFLUOROPHENYL)BUTAN-2-AMINE (2S,3S)-3-AMINO-4-(3,3-DIFLUOROPYRROLIDIN-1-YL)-N,N-DIMETHYL-4-OXO-2-(TRANS-4-[1,2,4]TRIAZOLO[1,5-A]PYRIDIN-6-YLCYCLOHEXYL)BUTANAMIDE (2S,3S)-3-AMINO-4-[(3S)-3-FLUOROPYRROLIDIN-1-YL]-N,N-DIMETHYL-4-OXO-2-(TRANS-4-[1,2,4]TRIAZOLO[1,5-A]PYRIDIN-5-YLCYCLOHEXYL)BUTANAMIDE (3R)-4-[(3R)-3-AMINO-4-(2,4,5-TRIFLUOROPHENYL)BUTANOYL]-3-METHYL-1,4-DIAZEPAN-2-ONE 4\'-[(1R)-1-amino-2-(2,5-difluorophenyl)ethyl]biphenyl-3-carboxamide (2R,3R)-7-(methylsulfonyl)-3-(2,4,5-trifluorophenyl)-1,2,3,4-tetrahydropyrido[1,2-a]benzimidazol-2-amine 7-(aminomethyl)-6-(2-chlorophenyl)-1-methyl-1H-benzimidazole-5-carbonitrile (3R)-4-[(3R)-3-AMINO-4-(2,4,5-TRIFLUOROPHENYL)BUTANOYL]-3-(2,2,2-TRIFLUOROETHYL)-1,4-DIAZEPAN-2-ONE METHYL 4-{[({[(2R,5S)-5-{[(2S)-2-(AMINOMETHYL)PYRROLIDIN-1-YL]CARBONYL}PYRROLIDIN-2-YL]METHYL}AMINO)CARBONYL]AMINO}BENZOATE (1S)-2-[(2S,5R)-2-(AMINOMETHYL)-5-ETHYNYLPYRROLIDIN-1-YL]-1-CYCLOPENTYL-2-OXOETHANAMINE 1-biphenyl-2-ylmethanamine (1S,3S,5S)-2-{(2S)-2-amino-2-[(1R,3S,5R,7S)-3-hydroxytricyclo[3.3.1.1~3,7~]dec-1-yl]acetyl}-2-azabicyclo[3.1.0]hexane-3-carbonitrile (2R)-N-[(2R)-2-(DIHYDROXYBORYL)-1-L-PROLYLPYRROLIDIN-2-YL]-N-[(5R)-5-(DIHYDROXYBORYL)-1-L-PROLYLPYRROLIDIN-2-YL]-L-PROLINAMIDE (3R,4S)-1-{6-[3-(METHYLSULFONYL)PHENYL]PYRIMIDIN-4-YL}-4-(2,4,5-TRIFLUOROPHENYL)PYRROLIDIN-3-AMINE N-({(2S)-1-[(3R)-3-AMINO-4-(2-FLUOROPHENYL)BUTANOYL]PYRROLIDIN-2-YL}METHYL)BENZAMIDE (4R,5R)-5-AMINO-1-[2-(1,3-BENZODIOXOL-5-YL)ETHYL]-4-(2,4,5-TRIFLUOROPHENYL)PIPERIDIN-2-ONE (3R,4S)-1-(3,4-DIMETHOXYPHENYL)-3-(3-METHYLPHENYL)PIPERIDIN-4-AMINE 1-[2-(S)-AMINO-3-BIPHENYL-4-YL-PROPIONYL]-PYRROLIDINE-2-(S)-CARBONITRILE (1S,6R)-3-{[3-(TRIFLUOROMETHYL)-5,6-DIHYDRO[1,2,4]TRIAZOLO[4,3-A]PYRAZIN-7(8H)-YL]CARBONYL}-6-(2,4,5-TRIFLUOROPHENYL)CYCLOHEX-3-EN-1-AMINE (2R)-4-(2-BENZOYL-1,2-DIAZEPAN-1-YL)-4-OXO-1-(2,4,5-TRIFLUOROPHENYL)BUTAN-2-AMINE (3R,4R)-1-{6-[3-(METHYLSULFONYL)PHENYL]PYRIMIDIN-4-YL}-4-(2,4,5-TRIFLUOROPHENYL)PIPERIDIN-3-AMINE 2-(4-{(3S,5S)-5-[(3,3-difluoropyrrolidin-1-yl)carbonyl]pyrrolidin-3-yl}piperazin-1-yl)pyrimidine N-({(2S)-1-[(3R)-3-amino-4-(3-chlorophenyl)butanoyl]pyrrolidin-2-yl}methyl)-3-(methylsulfonyl)benzamide (3R,4S)-1-[6-(6-METHOXYPYRIDIN-3-YL)PYRIMIDIN-4-YL]-4-(2,4,5-TRIFLUOROPHENYL)PYRROLIDIN-3-AMINE 6-(4-{(1S,2S)-2-AMINO-1-[(DIMETHYLAMINO)CARBONYL]-3-[(3S)-3-FLUOROPYRROLIDIN-1-YL]-3-OXOPROPYL}PHENYL)-1H-[1,2,4]TRIAZOLO[1,5-A]PYRIDIN-4-IUM 7-BENZYL-1,3-DIMETHYL-8-PIPERAZIN-1-YL-3,7-DIHYDRO-PURINE-2,6-DIONE 2-({2-[(3R)-3-AMINOPIPERIDIN-1-YL]-4-OXOQUINAZOLIN-3(4H)-YL}METHYL)BENZONITRILE 4-[(3R)-3-{[2-(4-FLUOROPHENYL)-2-OXOETHYL]AMINO}BUTYL]BENZAMIDE 2-({8-[(3R)-3-AMINOPIPERIDIN-1-YL]-1,3-DIMETHYL-2,6-DIOXO-1,2,3,6-TETRAHYDRO-7H-PURIN-7-YL}METHYL)BENZONITRILE Linagliptin
Diseases
GWAS		Hippocampal volume ( 22504421)
Protein-Protein Interactions		16 interactors: ADA CCL11 CCL22 CCL3L1 CCL5 CD4 CPAMD8 CXCL10 CXCL11 CXCL12 CXCL9 CXCR4 DKK1 FAP GRP PTPRC	9 interactors: BMF CCDC155 CCR3 CXCR3 DPP4 PAX8 PTPN5 SFTPC SYNE4
Entrez ID		1803	4283
HPRD ID		02187	03416
Ensembl ID		ENSG00000197635	ENSG00000138755
Uniprot IDs		P27487	Q07325
PDB IDs		1J2E 1N1M 1NU6 1NU8 1PFQ 1R9M 1R9N 1RWQ 1TK3 1TKR 1U8E 1W1I 1WCY 1X70 2AJL 2BGN 2BGR 2BUB 2FJP 2G5P 2G5T 2G63 2HHA 2I03 2I78 2IIT 2IIV 2JID 2OAG 2OGZ 2OLE 2ONC 2OPH 2OQI 2OQV 2P8S 2QJR 2QKY 2QOE 2QT9 2QTB 2RGU 2RIP 3BJM 3C43 3C45 3CCB 3CCC 3D4L 3EIO 3F8S 3G0B 3G0C 3G0D 3G0G 3H0C 3HAB 3HAC 3KWF 3KWJ 3NOX 3O95 3O9V 3OC0 3OPM 3Q0T 3Q8W 3QBJ 3SWW 3SX4 3VJK 3VJL 3VJM 3W2T 4A5S 4DSA 4DSZ 4DTC 4G1F 4JH0 4KR0 4L72 4LKO
Enriched GO Terms of Interacting Partners?		Cell Chemotaxis Cell Migration Locomotion Chemotaxis Cell Motility Chemokine-mediated Signaling Pathway Response To Virus Response To Other Organism Response To Biotic Stimulus Regulation Of Behavior Regulation Of Cell Migration Leukocyte Chemotaxis Response To External Stimulus Regulation Of Cell Motility Regulation Of Leukocyte Migration Inflammatory Response Regulation Of Locomotion Regulation Of Cellular Component Movement Movement Of Cell Or Subcellular Component Regulation Of Chemotaxis Immune System Process Positive Regulation Of Leukocyte Chemotaxis Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Immune Response Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Defense Response Positive Regulation Of Leukocyte Migration Positive Regulation Of Calcium Ion Transport Regulation Of Cell Proliferation Leukocyte Migration Positive Regulation Of Chemotaxis Positive Regulation Of Behavior Positive Regulation Of Intracellular Signal Transduction T Cell Chemotaxis Regulation Of Intracellular Signal Transduction Leukocyte Cell-cell Adhesion Positive Regulation Of Immune System Process Response To Stress Positive Regulation Of CAMP-mediated Signaling Regulation Of Calcium Ion Transport Regulation Of Signal Transduction Positive Regulation Of Ion Transport Lymphocyte Chemotaxis Response To Cytokine T Cell Migration Positive Regulation Of T Cell Migration Cytokine-mediated Signaling Pathway Regulation Of T Cell Migration	Chemokine-mediated Signaling Pathway Chromosome Localization To Nuclear Envelope Involved In Synapsis Regulation Of Thyroid-stimulating Hormone Secretion Regulation Of Endothelial Cell Proliferation Pronephric Field Specification Negative Regulation Of Apoptotic Process Involved In Metanephric Collecting Duct Development Negative Regulation Of Apoptotic Process Involved In Metanephric Nephron Tubule Development Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Metanephric Nephron Morphogenesis Positive Regulation Of Metanephric DCT Cell Differentiation Chemokine (C-C Motif) Ligand 11 Production Positive Regulation Of Angiogenesis Positive Regulation Of Thyroid Hormone Generation Kidney Rudiment Formation Thyroid-stimulating Hormone Signaling Pathway Metanephric Nephron Tubule Formation Positive Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Negative Regulation Of Extracellular Matrix Organization Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Nephron Morphogenesis Negative Regulation Of Extracellular Matrix Disassembly Positive Regulation Of Cytosolic Calcium Ion Concentration Metanephric Comma-shaped Body Morphogenesis Establishment Of Epithelial Cell Apical/basal Polarity Response To Cytokine Cytosolic Calcium Ion Homeostasis Metanephric Tubule Formation Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Metanephros Development Metanephric S-shaped Body Morphogenesis Regulation Of Thyroid Hormone Generation Comma-shaped Body Morphogenesis Anoikis Establishment Of Apical/basal Cell Polarity Metanephric Distal Convoluted Tubule Development Metanephric Nephron Tubule Morphogenesis Polarized Epithelial Cell Differentiation Positive Regulation Of Cell Proliferation Regulation Of Angiogenesis Pronephros Development Negative Regulation Of Execution Phase Of Apoptosis Positive Regulation Of Protein Homooligomerization S-shaped Body Morphogenesis Positive Regulation Of Intracellular Transport T Cell Chemotaxis Metanephric Distal Tubule Development Regulation Of Cell-cell Adhesion Mediated By Integrin Chemokine Production Establishment Of Monopolar Cell Polarity Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation
Tagcloud ?		albuminuria ameliorate bioavailability capability dipeptidyl english experimentally glp indirectly insufficient interfere journals language march microalbuminuria microangiopathy microvascular modifying nephropathy neuropathy nonincretin peer peptidase preliminary retinopathy retrieved scanned ulcer	academic assessing auc bacilli centre chemoattractant cxcl10 cxcl11 cxcr3 diagnosing differentiating gamma grades ifn immunoassays inducible ligands mig monokine pulmonary radiographic smear sputum surrogate tac tb tertiary usefulness
Tagcloud (Difference) ?		albuminuria ameliorate bioavailability capability dipeptidyl english experimentally glp indirectly insufficient interfere journals language march microalbuminuria microangiopathy microvascular modifying nephropathy neuropathy nonincretin peer peptidase preliminary retinopathy retrieved scanned ulcer	academic assessing auc bacilli centre chemoattractant cxcl10 cxcl11 cxcr3 diagnosing differentiating gamma grades ifn immunoassays inducible ligands mig monokine pulmonary radiographic smear sputum surrogate tac tb tertiary usefulness
Tagcloud (Intersection) ?