BAZ2A and KAT8

Number of citations of the paper that reports this interaction (PubMedID 19578370)
0

Data Source:
BioGRID (enzymatic study, affinity chromatography technology)

		BAZ2A	KAT8
Description		bromodomain adjacent to zinc finger domain 2A	lysine acetyltransferase 8
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromatin Silencing Complex Nucleolus Cytosol Nuclear Speck RDNA Heterochromatin NoRC Complex	Histone Acetyltransferase Complex Kinetochore Nucleus Nucleoplasm Chromosome Mitochondrion Nuclear Matrix Nuclear Lumen NuA4 Histone Acetyltransferase Complex NSL Complex MLL1 Complex MSL Complex
	Molecular Function	RNA Polymerase I Core Promoter Sequence-specific DNA Binding DNA Binding RNA Binding Protein Binding Zinc Ion Binding Nuclear Receptor Binding Histone Binding Metal Ion Binding Histone H4K16ac Reader Activity	Transcription Coactivator Activity Histone Acetyltransferase Activity Protein Binding Zinc Ion Binding Histone H4 Acetyltransferase Activity Acetyltransferase Activity Transferase Activity Acyltransferase Activity Enzyme Binding Histone H4K5 Acetyltransferase Activity Histone H4K8 Acetyltransferase Activity Metal Ion Binding Histone H4K16 Acetyltransferase Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Protein-lysine-acetyltransferase Activity Protein Propionyltransferase Activity DNA-binding Transcription Factor Binding Promoter-specific Chromatin Binding
	Biological Process	RDNA Heterochromatin Formation RNA Polymerase I Preinitiation Complex Assembly Chromatin Organization Chromatin Remodeling DNA Methylation-dependent Constitutive Heterochromatin Formation DNA-templated Transcription Regulation Of DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase I Heterochromatin Formation	Epithelial To Mesenchymal Transition Chromatin Organization Regulation Of DNA-templated Transcription Dosage Compensation By Inactivation Of X Chromosome Regulation Of Autophagy Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Epithelial To Mesenchymal Transition Skeletal Muscle Satellite Cell Differentiation Neurogenesis Hemopoiesis Myeloid Cell Differentiation Negative Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Post-embryonic Hemopoiesis Epigenetic Regulation Of Gene Expression Regulation Of Cell Differentiation Transcription Initiation-coupled Chromatin Remodeling Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Oogenesis Regulation Of MRNA Processing Negative Regulation Of Multicellular Organismal Process Positive Regulation Of Transcription Initiation By RNA Polymerase II Membraneless Organelle Assembly Positive Regulation Of Skeletal Muscle Satellite Cell Differentiation Regulation Of Mitochondrial Transcription
Pathways		NoRC negatively regulates rRNA expression	HATs acetylate histones Formation of WDR5-containing histone-modifying complexes
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Mean platelet volume ( 22139419 27863252 32888494) Platelet count ( 22139419 32888494) Platelet distribution width ( 32888494)	Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Body mass index ( 25673413) Family history of Alzheimer's disease ( 30617256) Parkinson's disease ( 28892059) Triglyceride levels ( 32154731)
Interacting Genes		8 interacting genes: ADRB2 DNMT1 DNMT3B H4C1 HDAC1 KAT8 SMARCA5 TTF1	15 interacting genes: ATM BAZ1B BAZ2A CEBPA FOXP3 H2AC8 H3C1 H4C1 H4C7 KMT2A PAF1 PLAU RNF2 TP53 TP53BP1
Entrez ID		11176	84148
HPRD ID		10417	11381
Ensembl ID		ENSG00000076108	ENSG00000103510
Uniprot IDs		F8VU39 J3KPG5 Q9UIF9	Q9H7Z6
PDB IDs		4LZ2 4Q6F 4QBM 4QF2 5AGQ 5MGJ 5MGK 5MGL 5MGM 5OR8 5T8R 6FAP 6FG6 6FGF 6FGG 6FGH 6FGI 6FGL 6FGV 6FGW 6FHU 6FI0 6FKP 7B7B 7B7G 7B7I 7B82 7BC2 7BL8 7BL9 7BLA 7BLB 7BLC 7BLD 7FHJ 7MWH 7MWI 7MWL 7QVT 7QVU 7QVV 7QWF 7QWU 7QWY 7QX2 7QX9 7QXL 7QYE 7QYO 7QYT 7QYU 7QYV 7QYW 7QZ0 7QZ4 7QZB 7QZC 7QZI 7QZT 7R01 7R0B	2GIV 2PQ8 2Y0M 3QAH 3TOA 3TOB 4DNC 5H43 5J8C 5J8F 5WCI 6BA2 6BA4 6CT2 6OIN 6OIO 6OIP 6OIQ 6OIR 6OWH 6OWI 6PD8 6PD9 6PDA 6PDB 6PDC 6PDD 6PDE 6PDF 6PDG 7CMR 8W13
Enriched GO Terms of Interacting Partners?		Chromatin Remodeling Negative Regulation Of Gene Expression, Epigenetic DNA-methyltransferase Activity Heterochromatin Formation DNA Methylation-dependent Constitutive Heterochromatin Formation Chromatin Organization DNA (cytosine-5-)-methyltransferase Activity Constitutive Heterochromatin Formation Promoter-specific Chromatin Binding Epigenetic Regulation Of Gene Expression Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Developmental Process Chromatin Binding DNA Binding Pericentric Heterochromatin Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cell Differentiation Negative Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process Nucleoplasm Negative Regulation Of Macromolecule Metabolic Process Heterochromatin Positive Regulation Of Biosynthetic Process Nucleus Negative Regulation Of Metabolic Process Nucleobase-containing Compound Biosynthetic Process Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Positive Regulation Of Mini Excitatory Postsynaptic Potential Negative Regulation Of Muscle Cell Differentiation DNA (cytosine-5-)-methyltransferase Activity, Acting On CpG Substrates DNA-templated Transcription Initiation DNA-templated Transcription Enzyme Binding Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Regulation Of RNA Biosynthetic Process Beta2-adrenergic Receptor Activity Negative Regulation Of Vascular Associated Smooth Muscle Cell Differentiation Involved In Phenotypic Switching Positive Regulation Of Smooth Muscle Cell Proliferation Chromosomal DNA Methylation Maintenance Following DNA Replication Krueppel-associated Box Domain Binding WICH Complex Negative Regulation Of Mitotic Chromosome Condensation ISWI-type Complex NoRC Complex Histone Octamer Slider Activity	Chromatin Remodeling Chromatin Organization DNA Binding Epigenetic Regulation Of Gene Expression Response To X-ray Regulation Of Gene Expression Positive Regulation Of Transcription By RNA Polymerase II Protein Heterodimerization Activity Structural Constituent Of Chromatin Regulation Of Macromolecule Biosynthetic Process Protein Localization To Chromosome Nucleosome Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA Metabolic Process Chromosome Negative Regulation Of DNA Recombination Negative Regulation Of Cell Population Proliferation Cellular Response To X-ray Positive Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Cell Cycle Cellular Response To Ionizing Radiation Positive Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Protein-DNA Complex Assembly DNA Repair Complex DNA Strand Resection Involved In Replication Fork Processing Negative Regulation Of Chromosome Organization Replicative Senescence Negative Regulation Of Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein Localization To Organelle Negative Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Gene Expression CENP-A Containing Nucleosome Protein Localization To CENP-A Containing Chromatin Regulation Of Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Hematopoietic Or Lymphoid Organ Development Site Of Double-strand Break DNA Damage Checkpoint Signaling Alpha-beta T Cell Activation Regulation Of Cell Population Proliferation Regulation Of Integrin-mediated Signaling Pathway
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