BAZ2A and SMARCA5

Number of citations of the paper that reports this interaction (PubMedID 11532953)
40

Data Source:
HPRD (in vitro, in vivo)

		BAZ2A	SMARCA5
Description		bromodomain adjacent to zinc finger domain 2A	SNF2 related chromatin remodeling ATPase 5
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromatin Silencing Complex Nucleolus Cytosol Nuclear Speck RDNA Heterochromatin NoRC Complex	Chromatin Condensed Chromosome Fibrillar Center Nucleus Nucleoplasm Chromatin Silencing Complex Chromosome Pericentric Heterochromatin Nucleolus CHRAC NURF Complex ACF Complex ISWI-type Complex RSF Complex Site Of Double-strand Break Nuclear Replication Fork WICH Complex NoRC Complex CERF Complex B-WICH Complex
	Molecular Function	RNA Polymerase I Core Promoter Sequence-specific DNA Binding DNA Binding RNA Binding Protein Binding Zinc Ion Binding Nuclear Receptor Binding Histone Binding Metal Ion Binding Histone H4K16ac Reader Activity	DNA Binding Chromatin Binding Helicase Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Nucleosome Binding Histone Binding ATP-dependent Chromatin Remodeler Activity Nucleosome Array Spacer Activity Histone Octamer Slider Activity
	Biological Process	RDNA Heterochromatin Formation RNA Polymerase I Preinitiation Complex Assembly Chromatin Organization Chromatin Remodeling DNA Methylation-dependent Constitutive Heterochromatin Formation DNA-templated Transcription Regulation Of DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase I Heterochromatin Formation	RDNA Heterochromatin Formation Regulation Of DNA Replication DNA Repair Chromatin Organization Nucleosome Assembly Chromatin Remodeling DNA Methylation-dependent Constitutive Heterochromatin Formation DNA-templated Transcription Initiation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II DNA Damage Response Negative Regulation Of Transcription By RNA Polymerase I Heterochromatin Formation Positive Regulation Of DNA Replication Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase I Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase III Antiviral Innate Immune Response Negative Regulation Of Mitotic Chromosome Condensation Cellular Response To Leukemia Inhibitory Factor
Pathways		NoRC negatively regulates rRNA expression	NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Deposition of new CENPA-containing nucleosomes at the centromere
Drugs			Beta-D-Glucose 4-Deoxy-Alpha-D-Glucose
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Mean platelet volume ( 22139419 27863252 32888494) Platelet count ( 22139419 32888494) Platelet distribution width ( 32888494)	Appendicular lean mass ( 33097823) Height ( 31562340) Malaria ( 31844061)
Interacting Genes		8 interacting genes: ADRB2 DNMT1 DNMT3B H4C1 HDAC1 KAT8 SMARCA5 TTF1	20 interacting genes: BAZ1A BAZ1B BAZ2A CDT1 CHRAC1 CREB1 CTNNB1 DNMT3B GSK3A H3-3A H3C1 H4C16 HDAC2 MAF POLE3 PTEN RAD21 RSF1 SATB1 USP7
Entrez ID		11176	8467
HPRD ID		10417	04538
Ensembl ID		ENSG00000076108	ENSG00000153147
Uniprot IDs		F8VU39 J3KPG5 Q9UIF9	O60264
PDB IDs		4LZ2 4Q6F 4QBM 4QF2 5AGQ 5MGJ 5MGK 5MGL 5MGM 5OR8 5T8R 6FAP 6FG6 6FGF 6FGG 6FGH 6FGI 6FGL 6FGV 6FGW 6FHU 6FI0 6FKP 7B7B 7B7G 7B7I 7B82 7BC2 7BL8 7BL9 7BLA 7BLB 7BLC 7BLD 7FHJ 7MWH 7MWI 7MWL 7QVT 7QVU 7QVV 7QWF 7QWU 7QWY 7QX2 7QX9 7QXL 7QYE 7QYO 7QYT 7QYU 7QYV 7QYW 7QZ0 7QZ4 7QZB 7QZC 7QZI 7QZT 7R01 7R0B	6NE3 8V4Y 8V6V 8V7L 9E1L 9E1M 9E1N 9E1O 9E1P 9E1Q 9E1R 9E1U 9E1V 9E1W 9E1X
Enriched GO Terms of Interacting Partners?		Chromatin Remodeling Negative Regulation Of Gene Expression, Epigenetic DNA-methyltransferase Activity Heterochromatin Formation DNA Methylation-dependent Constitutive Heterochromatin Formation Chromatin Organization DNA (cytosine-5-)-methyltransferase Activity Constitutive Heterochromatin Formation Promoter-specific Chromatin Binding Epigenetic Regulation Of Gene Expression Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Developmental Process Chromatin Binding DNA Binding Pericentric Heterochromatin Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cell Differentiation Negative Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process Nucleoplasm Negative Regulation Of Macromolecule Metabolic Process Heterochromatin Positive Regulation Of Biosynthetic Process Nucleus Negative Regulation Of Metabolic Process Nucleobase-containing Compound Biosynthetic Process Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Positive Regulation Of Mini Excitatory Postsynaptic Potential Negative Regulation Of Muscle Cell Differentiation DNA (cytosine-5-)-methyltransferase Activity, Acting On CpG Substrates DNA-templated Transcription Initiation DNA-templated Transcription Enzyme Binding Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Regulation Of RNA Biosynthetic Process Beta2-adrenergic Receptor Activity Negative Regulation Of Vascular Associated Smooth Muscle Cell Differentiation Involved In Phenotypic Switching Positive Regulation Of Smooth Muscle Cell Proliferation Chromosomal DNA Methylation Maintenance Following DNA Replication Krueppel-associated Box Domain Binding WICH Complex Negative Regulation Of Mitotic Chromosome Condensation ISWI-type Complex NoRC Complex Histone Octamer Slider Activity	Chromatin Remodeling Chromatin Organization Protein-DNA Complex Assembly Nucleosome Assembly Nucleosome Organization Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Nucleus Regulation Of Macromolecule Metabolic Process CHRAC Negative Regulation Of Metabolic Process Epigenetic Regulation Of Gene Expression Regulation Of Metabolic Process Pericentric Heterochromatin DNA Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Nucleoplasm Negative Regulation Of Biosynthetic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Chromatin Negative Regulation Of Gene Expression, Epigenetic Macromolecule Metabolic Process Cellular Component Assembly Regulation Of Transcription By RNA Polymerase II Nucleic Acid Metabolic Process Fungiform Papilla Formation Protein-containing Complex Assembly Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Chromosome Organization Negative Regulation Of Chromosome Condensation Regulation Of DNA Replication Negative Regulation Of RNA Metabolic Process Protein-containing Complex Organization Hair Follicle Placode Formation Epsilon DNA Polymerase Complex Regulation Of DNA Metabolic Process Positive Regulation Of Metabolic Process Heterochromatin Formation Negative Regulation Of Gene Expression DNA Replication DNA-templated DNA Replication Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleobase-containing Compound Metabolic Process
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