FZD4

Description		frizzled class receptor 4
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GO Annotations	Cellular Component	Nucleoplasm Plasma Membrane Cell-cell Junction Cilium Cell Surface Membrane Dendrite Clathrin-coated Endocytic Vesicle Membrane Synapse Glutamatergic Synapse
	Molecular Function	Amyloid-beta Binding Transmembrane Signaling Receptor Activity Cytokine Receptor Activity G Protein-coupled Receptor Activity Protein Binding Wnt-protein Binding Cytokine Binding PDZ Domain Binding Ubiquitin Protein Ligase Binding Signaling Receptor Activity Protein Homodimerization Activity Wnt Receptor Activity Protein-containing Complex Binding Protein Heterodimerization Activity
	Biological Process	Angiogenesis Luteinization Blood Vessel Development Vasculogenesis Response To Hypoxia Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Wnt Signaling Pathway, Calcium Modulating Pathway Sensory Perception Of Sound Cell Population Proliferation Negative Regulation Of Cell-substrate Adhesion Wnt Signaling Pathway Cytokine-mediated Signaling Pathway Neuron Differentiation Positive Regulation Of Cell Migration Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Locomotion Involved In Locomotory Behavior Substrate Adhesion-dependent Cell Spreading Extracellular Matrix-cell Signaling Non-canonical Wnt Signaling Pathway Progesterone Secretion Endothelial Cell Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Dendrite Morphogenesis Canonical Wnt Signaling Pathway Establishment Of Blood-brain Barrier Retina Vasculature Development In Camera-type Eye Retina Vasculature Morphogenesis In Camera-type Eye Cerebellum Vasculature Morphogenesis Retinal Blood Vessel Morphogenesis Cellular Response To Retinoic Acid Norrin Signaling Pathway Positive Regulation Of Neuron Projection Arborization Cellular Response To Leukemia Inhibitory Factor
Pathways		Class B/2 (Secretin family receptors) Ca2+ pathway Ca2+ pathway Asymmetric localization of PCP proteins Regulation of FZD by ubiquitination WNT5A-dependent internalization of FZD4 Signaling by RNF43 mutants Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs
Diseases		Familial exudative vitreoretinopathy (FEVR), including: Exudative vitreoretinopathy 1 (EVR1); Exudative vitreoretinopathy2, X-linked (EVR2); Exudative vitreoretinopathy 4 (EVR4); Exudative vitreoretinopathy 5 (EVR5); Norrie disease (ND)
GWAS		Hepatocellular carcinoma in hepatitis B infection ( 26870257)
Interacting Genes		7 interacting genes: ARRB2 BAG6 DLG1 DLG2 DLG4 DVL2 MAGI3
Entrez ID		8322
HPRD ID		05203
Ensembl ID		ENSG00000174804
Uniprot IDs		Q9ULV1
PDB IDs		5BPB 5BPQ 5BQC 5BQE 5CL1 5CM4 5UWG 6BD4 6NE1 8WM9 8WMA
Enriched GO Terms of Interacting Partners?		GMP Kinase Activity GDP Metabolic Process GMP Metabolic Process Ionotropic Glutamate Receptor Binding Receptor Localization To Synapse Receptor Clustering Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Protein Localization To Synapse Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Nucleoside Monophosphate Metabolic Process D1 Dopamine Receptor Binding Neuromuscular Junction Ribonucleoside Diphosphate Metabolic Process Nucleoside Diphosphate Metabolic Process Protein Localization To Cell Junction Positive Regulation Of Neuron Projection Arborization Kinase Binding Postsynaptic Density Membrane Juxtaparanode Region Of Axon Cellular Response To Potassium Ion Regulation Of Neuron Projection Arborization Protein Kinase Binding Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Establishment Or Maintenance Of Cell Polarity Localization Within Membrane Response To Potassium Ion Molecular Adaptor Activity Adherens Junction Cell Junction Protein-macromolecule Adaptor Activity Protein Localization To Postsynaptic Membrane Protein Localization To Postsynapse Frizzled Binding Regulation Of Cell Morphogenesis Postsynaptic Density Purine Ribonucleotide Metabolic Process Ribonucleotide Metabolic Process Ribose Phosphate Metabolic Process Protein Localization To Membrane Intracellular Protein Localization Chemical Synaptic Transmission Intracellular Signal Transduction Neuron Projection Trans-synaptic Signaling Synaptic Signaling Synaptic Membrane Purine Nucleotide Metabolic Process Lateral Plasma Membrane Protein-containing Complex Localization
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