FZD4 and DVL2

Number of citations of the paper that reports this interaction (PubMedID 12958364)
0

Data Source:
HPRD (in vivo)

		FZD4	DVL2
Description		frizzled class receptor 4	dishevelled segment polarity protein 2
Image
GO Annotations	Cellular Component	Nucleoplasm Plasma Membrane Cell-cell Junction Cilium Cell Surface Membrane Dendrite Clathrin-coated Endocytic Vesicle Membrane Synapse Glutamatergic Synapse	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane Aggresome Lateral Plasma Membrane Nuclear Body Clathrin-coated Vesicle Cytoplasmic Vesicle Apical Part Of Cell Clathrin-coated Endocytic Vesicle
	Molecular Function	Amyloid-beta Binding Transmembrane Signaling Receptor Activity Cytokine Receptor Activity G Protein-coupled Receptor Activity Protein Binding Wnt-protein Binding Cytokine Binding PDZ Domain Binding Ubiquitin Protein Ligase Binding Signaling Receptor Activity Protein Homodimerization Activity Wnt Receptor Activity Protein-containing Complex Binding Protein Heterodimerization Activity	Frizzled Binding Protein Binding Protein Kinase Binding Protein Domain Specific Binding Protein-macromolecule Adaptor Activity Small GTPase Binding Identical Protein Binding
	Biological Process	Angiogenesis Luteinization Blood Vessel Development Vasculogenesis Response To Hypoxia Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Wnt Signaling Pathway, Calcium Modulating Pathway Sensory Perception Of Sound Cell Population Proliferation Negative Regulation Of Cell-substrate Adhesion Wnt Signaling Pathway Cytokine-mediated Signaling Pathway Neuron Differentiation Positive Regulation Of Cell Migration Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Locomotion Involved In Locomotory Behavior Substrate Adhesion-dependent Cell Spreading Extracellular Matrix-cell Signaling Non-canonical Wnt Signaling Pathway Progesterone Secretion Endothelial Cell Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Dendrite Morphogenesis Canonical Wnt Signaling Pathway Establishment Of Blood-brain Barrier Retina Vasculature Development In Camera-type Eye Retina Vasculature Morphogenesis In Camera-type Eye Cerebellum Vasculature Morphogenesis Retinal Blood Vessel Morphogenesis Cellular Response To Retinoic Acid Norrin Signaling Pathway Positive Regulation Of Neuron Projection Arborization Cellular Response To Leukemia Inhibitory Factor	Neural Tube Closure Heart Looping Heart Morphogenesis Outflow Tract Morphogenesis Regulation Of DNA-templated Transcription Segment Specification Heart Development Intracellular Protein Localization Wnt Signaling Pathway Convergent Extension Involved In Neural Plate Elongation Regulation Of Actin Cytoskeleton Organization Segmentation Intracellular Signal Transduction Non-canonical Wnt Signaling Pathway Regulation Of Cell Population Proliferation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JNK Cascade Convergent Extension Involved In Organogenesis Canonical Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Cochlea Morphogenesis Positive Regulation Of Neuron Projection Arborization Positive Regulation Of Signal Transduction By P53 Class Mediator
Pathways		Class B/2 (Secretin family receptors) Ca2+ pathway Ca2+ pathway Asymmetric localization of PCP proteins Regulation of FZD by ubiquitination WNT5A-dependent internalization of FZD4 Signaling by RNF43 mutants Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis	TCF dependent signaling in response to WNT WNT mediated activation of DVL Signaling by Hippo PCP/CE pathway PCP/CE pathway Asymmetric localization of PCP proteins Degradation of DVL Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane WNT5A-dependent internalization of FZD4 Negative regulation of TCF-dependent signaling by DVL-interacting proteins RHO GTPases Activate Formins Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis WNT5:FZD7-mediated leishmania damping WNT5:FZD7-mediated leishmania damping
Drugs
Diseases		Familial exudative vitreoretinopathy (FEVR), including: Exudative vitreoretinopathy 1 (EVR1); Exudative vitreoretinopathy2, X-linked (EVR2); Exudative vitreoretinopathy 4 (EVR4); Exudative vitreoretinopathy 5 (EVR5); Norrie disease (ND)
GWAS		Hepatocellular carcinoma in hepatitis B infection ( 26870257)	Metabolite levels ( 31628463)
Interacting Genes		7 interacting genes: ARRB2 BAG6 DLG1 DLG2 DLG4 DVL2 MAGI3	105 interacting genes: ABL1 AKAP9 AP1M1 AP2M1 AQP9 ARHGEF39 ARR3 ARRB1 ARRB2 ATN1 AXIN1 BAG3 BAHD1 BCL6 BEND7 BYSL CARD9 CCDC33 CPSF7 CSNK1E CTBP2 CUL1 DAAM1 DCUN1D1 DDI1 DPPA2 DYNLT1 EIF1B ELOA2 ENKD1 FAM161A FAM90A1 FZD4 GABARAP GABARAPL1 GMCL2 GOLGA2 GRAP2 GRB2 HIP1 IHO1 LMO3 LRRK2 MAGOHB MAP1LC3A MCRS1 NOL12 NUP62CL OTULIN PARD6A PCBD1 PLA2G12A POLI PPM1A PPP1R16B PRKAA1 PRKCA PRKCB PRKCG PRPF3 PRPF31 PSMF1 RAC1 RAP1B RBFOX1 RBPMS RHOA RHOXF2 RNF185 RNPS1 RUNX2 RUSC1 SCNM1 SMURF1 SNF8 SNIP1 SORBS3 SSX2IP TAB1 TDP2 THAP1 TIFA TLE5 TP53 TPM3 TRAF2 U2AF2 UBAC1 UIMC1 USP5 USP9X VANGL1 VHL WAS WT1 WWP2 YES1 ZBTB48 ZBTB8A ZGPAT ZNF165 ZNF250 ZNF263 ZNF410 ZNF581
Entrez ID		8322	1856
HPRD ID		05203	03690
Ensembl ID		ENSG00000174804	ENSG00000004975
Uniprot IDs		Q9ULV1	O14641
PDB IDs		5BPB 5BPQ 5BQC 5BQE 5CL1 5CM4 5UWG 6BD4 6NE1 8WM9 8WMA	2REY 3CBX 3CBY 3CBZ 3CC0 4WIP 5LNP 5SUY 5SUZ 6IW3 6JCK 8WM9 8WMA 8WWR 8YR7
Enriched GO Terms of Interacting Partners?		GMP Kinase Activity GDP Metabolic Process GMP Metabolic Process Ionotropic Glutamate Receptor Binding Receptor Localization To Synapse Receptor Clustering Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Protein Localization To Synapse Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Nucleoside Monophosphate Metabolic Process D1 Dopamine Receptor Binding Neuromuscular Junction Ribonucleoside Diphosphate Metabolic Process Nucleoside Diphosphate Metabolic Process Protein Localization To Cell Junction Positive Regulation Of Neuron Projection Arborization Kinase Binding Postsynaptic Density Membrane Juxtaparanode Region Of Axon Cellular Response To Potassium Ion Regulation Of Neuron Projection Arborization Protein Kinase Binding Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Establishment Or Maintenance Of Cell Polarity Localization Within Membrane Response To Potassium Ion Molecular Adaptor Activity Adherens Junction Cell Junction Protein-macromolecule Adaptor Activity Protein Localization To Postsynaptic Membrane Protein Localization To Postsynapse Frizzled Binding Regulation Of Cell Morphogenesis Postsynaptic Density Purine Ribonucleotide Metabolic Process Ribonucleotide Metabolic Process Ribose Phosphate Metabolic Process Protein Localization To Membrane Intracellular Protein Localization Chemical Synaptic Transmission Intracellular Signal Transduction Neuron Projection Trans-synaptic Signaling Synaptic Signaling Synaptic Membrane Purine Nucleotide Metabolic Process Lateral Plasma Membrane Protein-containing Complex Localization	Protein Binding Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Nucleus Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Non-canonical Wnt Signaling Pathway Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Wnt Signaling Pathway Regulation Of Signal Transduction Intracellular Signaling Cassette Negative Regulation Of Macromolecule Metabolic Process Regulation Of Intracellular Signal Transduction Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Regulation Of Protein Metabolic Process Positive Regulation Of Intracellular Signal Transduction Cytosol Protein Modification By Small Protein Conjugation Protein Ubiquitination Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Protein Modification Process Nucleoplasm Cytoplasm Regulation Of Signaling Regulation Of Cell Communication Regulation Of Protein Ubiquitination Negative Regulation Of Protein Metabolic Process Negative Regulation Of Biosynthetic Process Protein Modification Process Cellular Component Assembly Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Enzyme Binding Cytoskeleton Regulation Of Transcription By RNA Polymerase II Intracellular Signal Transduction Macromolecule Metabolic Process Positive Regulation Of Signal Transduction Regulation Of MAPK Cascade Negative Regulation Of RNA Metabolic Process Post-translational Protein Modification Autophagy
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?