DIAPH2 and NCKIPSD

Number of citations of the paper that reports this interaction (PubMedID 11509578)
0

Data Source:
HPRD (in vitro, in vivo)

		DIAPH2	NCKIPSD
Description		diaphanous related formin 2	NCK interacting protein with SH3 domain
Image		No pdb structure
GO Annotations	Cellular Component	Nucleolus Cytoplasm Endosome Early Endosome Endoplasmic Reticulum Cytosol Actin Filament	Nucleus Nucleoplasm Cytosol Intermediate Filament Plasma Membrane COP9 Signalosome Postsynapse Glutamatergic Synapse
	Molecular Function	Actin Binding Signaling Receptor Binding Small GTPase Binding	Protein Binding Cytoskeletal Protein Binding SH3 Domain Binding Arp2/3 Complex Binding
	Biological Process	Female Gamete Generation Actin Cytoskeleton Organization Actin Filament Polymerization Cell Differentiation Oogenesis	Endocytosis Cytoskeleton Organization Positive Regulation Of Neuron Projection Development Regulation Of Postsynapse Assembly
Pathways		RHOF GTPase cycle	Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs
Diseases
GWAS			A body shape index ( 34021172) Anorexia nervosa ( 31308545) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Intelligence (MTAG) ( 29326435) Myocardial infarction ( 33532862) Parkinson's disease ( 28892059) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172)
Interacting Genes		6 interacting genes: APBB1 CDC42 CENPA NCKIPSD RHOD TCERG1	42 interacting genes: ABI2 AKT1 ARHGEF7 BAIAP2 CCDC187 CPNE2 CYSLTR2 DIAPH2 DIAPH3 DLG4 DMRTB1 ENKD1 FASLG GRB2 HSPB1 ITGB1 KHDRBS1 LGALS4 MAPK3 MED25 NCK1 NCK2 PIN1 PKP2 POLR3C PRPF31 PSMD9 PSORS1C2 RBM22 RBP7 RXFP3 SHANK3 SNRPC SORBS3 STAC TSEN54 VEZF1 WAS WASL YWHAG ZBTB47 ZC2HC1C
Entrez ID		1730	51517
HPRD ID		02117	09450
Ensembl ID		ENSG00000147202	ENSG00000213672
Uniprot IDs		O60879	Q9NZQ3
PDB IDs			6DEC 6DED 6DEE
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Component Organization Regulation Of Plasma Membrane Bounded Cell Projection Organization Positive Regulation Of Neuron Projection Development Cell Projection Morphogenesis Transcription Coactivator Activity Neuron Projection Morphogenesis Cell Projection Organization Positive Regulation Of Cell Projection Organization Regulation Of Cell Projection Organization Leading Edge Membrane Positive Regulation Of Pseudopodium Assembly Endothelin Receptor Signaling Pathway Thioesterase Binding Positive Regulation Of Pinocytosis Apolipoprotein A-I Receptor Binding Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis G Protein-coupled Receptor Signaling Pathway Involved In Heart Process GTPase Activity Golgi Localization Regulation Of Postsynapse Organization Endothelin Receptor Signaling Pathway Involved In Heart Process Actin Filament Organization Cytoskeleton Organization Small GTPase-mediated Signal Transduction Cell Junction Assembly Neuron Fate Determination Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Establishment Of Golgi Localization Establishment Of Organelle Localization Neuropilin Signaling Pathway Postsynapse Regulation Of Synapse Organization GBD Domain Binding Golgi Transport Complex Storage Vacuole Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Regulation Of Cell-substrate Adhesion CENP-A Containing Chromatin CENP-A Containing Chromatin Assembly Kinetochore Assembly Transcription Elongation Factor Activity Ubiquitin-like Protein Conjugating Enzyme Binding Regulation Of Cell Junction Assembly Arp2/3 Complex Binding Regulation Of Cellular Component Organization Proline-rich Region Binding Cell Projection Regulation Of Actin Cytoskeleton Organization Cell Projection Assembly Cardiac Conduction System Development	Actin Filament Organization Supramolecular Fiber Organization Regulation Of Supramolecular Fiber Organization Regulation Of Cytoskeleton Organization Positive Regulation Of Cellular Component Organization Regulation Of Translational Initiation Actin Polymerization Or Depolymerization Cellular Component Assembly Regulation Of Actin Filament Organization Regulation Of Actin Filament-based Process Cytoskeletal Anchor Activity Actin Filament Polymerization Protein Polymerization Regulation Of Actin Cytoskeleton Organization Lamellipodium Assembly Vesicle Membrane Negative Regulation Of PERK-mediated Unfolded Protein Response Regulation Of Organelle Organization Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of Supramolecular Fiber Organization Lamellipodium Organization Positive Regulation Of Translational Initiation Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Cytoskeleton Organization Lamellipodium Regulation Of Cellular Component Organization Regulation Of PERK-mediated Unfolded Protein Response Positive Regulation Of Fibroblast Migration SH3 Domain Binding Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Dendritic Spine Morphogenesis Epidermal Growth Factor Receptor Signaling Pathway Protein Kinase C Inhibitor Activity Cytoskeleton Organization Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Postsynapse Organization Positive Regulation Of Cell Projection Organization Regulation Of Actin Polymerization Or Depolymerization Positive Regulation Of Organelle Organization Scaffold Protein Binding Regulation Of Actin Filament Length Regulation Of Cell Projection Organization Protein-containing Complex Assembly Dendritic Spine Regulation Of Cellular Component Size Regulation Of Translation Initiation In Response To Endoplasmic Reticulum Stress ERBB Signaling Pathway Positive Regulation Of Translation Insulin Receptor Signaling Pathway
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