DIAPH2 and RHOD

Number of citations of the paper that reports this interaction (PubMedID 12577064)
0

Data Source:
HPRD (in vitro, in vivo)

		DIAPH2	RHOD
Description		diaphanous related formin 2	ras homolog family member D
Image		No pdb structure
GO Annotations	Cellular Component	Nucleolus Cytoplasm Endosome Early Endosome Endoplasmic Reticulum Cytosol Actin Filament	Golgi Membrane Mitochondrial Outer Membrane Endosome Early Endosome Cytosol Plasma Membrane Endosome Membrane Membrane Cell Projection
	Molecular Function	Actin Binding Signaling Receptor Binding Small GTPase Binding	Nucleotide Binding GTPase Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding GTP Binding Protein Kinase Binding
	Biological Process	Female Gamete Generation Actin Cytoskeleton Organization Actin Filament Polymerization Cell Differentiation Oogenesis	Protein Targeting Actin Filament Organization Small GTPase-mediated Signal Transduction Rho Protein Signal Transduction Fibroblast Growth Factor Receptor Signaling Pathway Cell Projection Assembly Lamellipodium Assembly Actin Filament Polymerization Positive Regulation Of Cell Migration Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Cell Adhesion Focal Adhesion Assembly Actin Filament Bundle Assembly Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Focal Adhesion Assembly Response To Fibroblast Growth Factor
Pathways		RHOF GTPase cycle	RHO GTPases Activate Formins RHOD GTPase cycle
Drugs
Diseases
GWAS			Height ( 20881960 25282103) Hip circumference adjusted for BMI ( 34021172) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		6 interacting genes: APBB1 CDC42 CENPA NCKIPSD RHOD TCERG1	13 interacting genes: ACVR1 ADCK5 ADRB2 ANKFY1 BMPR1B DIAPH2 HRAS IHH PLXNA1 SMAD2 SMAD4 SMURF2 TGFBR1
Entrez ID		1730	29984
HPRD ID		02117	05776
Ensembl ID		ENSG00000147202	ENSG00000173156
Uniprot IDs		O60879	E9PIG5 O00212
PDB IDs			2J1L 7KDC
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Component Organization Regulation Of Plasma Membrane Bounded Cell Projection Organization Positive Regulation Of Neuron Projection Development Cell Projection Morphogenesis Transcription Coactivator Activity Neuron Projection Morphogenesis Cell Projection Organization Positive Regulation Of Cell Projection Organization Regulation Of Cell Projection Organization Leading Edge Membrane Positive Regulation Of Pseudopodium Assembly Endothelin Receptor Signaling Pathway Thioesterase Binding Positive Regulation Of Pinocytosis Apolipoprotein A-I Receptor Binding Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis G Protein-coupled Receptor Signaling Pathway Involved In Heart Process GTPase Activity Golgi Localization Regulation Of Postsynapse Organization Endothelin Receptor Signaling Pathway Involved In Heart Process Actin Filament Organization Cytoskeleton Organization Small GTPase-mediated Signal Transduction Cell Junction Assembly Neuron Fate Determination Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Establishment Of Golgi Localization Establishment Of Organelle Localization Neuropilin Signaling Pathway Postsynapse Regulation Of Synapse Organization GBD Domain Binding Golgi Transport Complex Storage Vacuole Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Regulation Of Cell-substrate Adhesion CENP-A Containing Chromatin CENP-A Containing Chromatin Assembly Kinetochore Assembly Transcription Elongation Factor Activity Ubiquitin-like Protein Conjugating Enzyme Binding Regulation Of Cell Junction Assembly Arp2/3 Complex Binding Regulation Of Cellular Component Organization Proline-rich Region Binding Cell Projection Regulation Of Actin Cytoskeleton Organization Cell Projection Assembly Cardiac Conduction System Development	SMAD Binding Transforming Growth Factor Beta Receptor Activity, Type I Activin Receptor Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Activity Cell Surface Receptor Signaling Pathway Positive Regulation Of Epithelial To Mesenchymal Transition Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Fate Commitment Pattern Specification Process Positive Regulation Of Signal Transduction Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Tissue Morphogenesis I-SMAD Binding Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling In Utero Embryonic Development Chordate Embryonic Development Transforming Growth Factor Beta Receptor Signaling Pathway Embryo Development Ending In Birth Or Egg Hatching Multicellular Organism Development Positive Regulation Of Developmental Process Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regionalization Animal Organ Morphogenesis Regulation Of Epithelial To Mesenchymal Transition Cellular Response To BMP Stimulus Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Activin Responsive Factor Complex Regulation Of Ossification Osteoblast Differentiation Ameboidal-type Cell Migration Anatomical Structure Morphogenesis Response To Growth Factor Neuron Fate Commitment Ventricular Septum Morphogenesis Positive Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Bone Mineralization Enzyme-linked Receptor Protein Signaling Pathway Developmental Growth Gastrulation Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Biomineral Tissue Development Tissue Development Regulation Of Chondrocyte Differentiation Positive Regulation Of Ossification Mesoderm Development Embryonic Morphogenesis Activin Receptor Complex
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