DIAPH2 and CENPA

Number of citations of the paper that reports this interaction (PubMedID 15085137)
0

Data Source:
HPRD (in vivo, two hybrid)

		DIAPH2	CENPA
Description		diaphanous related formin 2	centromere protein A
Image		No pdb structure
GO Annotations	Cellular Component	Nucleolus Cytoplasm Endosome Early Endosome Endoplasmic Reticulum Cytosol Actin Filament	Chromosome, Centromeric Region Condensed Chromosome, Centromeric Region Nucleosome Nucleus Nucleoplasm Chromosome Pericentric Heterochromatin Cytosol CENP-A Containing Nucleosome CENP-A Containing Chromatin
	Molecular Function	Actin Binding Signaling Receptor Binding Small GTPase Binding	DNA Binding Chromatin Binding Protein Binding Structural Constituent Of Chromatin Protein Heterodimerization Activity
	Biological Process	Female Gamete Generation Actin Cytoskeleton Organization Actin Filament Polymerization Cell Differentiation Oogenesis	Establishment Of Mitotic Spindle Orientation Mitotic Cytokinesis CENP-A Containing Chromatin Assembly Cell Division Kinetochore Assembly Protein Localization To CENP-A Containing Chromatin Protein Localization To Chromosome, Centromeric Region
Pathways		RHOF GTPase cycle	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Deposition of new CENPA-containing nucleosomes at the centromere Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS			Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		6 interacting genes: APBB1 CDC42 CENPA NCKIPSD RHOD TCERG1	11 interacting genes: AURKB AURKC CDKN2A CUL4A DIAPH1 DIAPH2 H3C3 H4C6 HJURP PARP1 PARP2
Entrez ID		1730	1058
HPRD ID		02117	00313
Ensembl ID		ENSG00000147202	ENSG00000115163
Uniprot IDs		O60879	P49450
PDB IDs			3AN2 3NQJ 3NQU 3R45 3WTP 5CVD 5Z23 6BUZ 6C0W 6E0C 6E0P 6KDQ 6KDS 6L49 6MUO 6MUP 6O1D 6SE0 6SE6 6SEE 6SEF 6SEG 6TEM 7D20 7PII 7R5R 7U46 7U47 7U4D 7YWX 7YYH 9GXA
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Component Organization Regulation Of Plasma Membrane Bounded Cell Projection Organization Positive Regulation Of Neuron Projection Development Cell Projection Morphogenesis Transcription Coactivator Activity Neuron Projection Morphogenesis Cell Projection Organization Positive Regulation Of Cell Projection Organization Regulation Of Cell Projection Organization Leading Edge Membrane Positive Regulation Of Pseudopodium Assembly Endothelin Receptor Signaling Pathway Thioesterase Binding Positive Regulation Of Pinocytosis Apolipoprotein A-I Receptor Binding Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis G Protein-coupled Receptor Signaling Pathway Involved In Heart Process GTPase Activity Golgi Localization Regulation Of Postsynapse Organization Endothelin Receptor Signaling Pathway Involved In Heart Process Actin Filament Organization Cytoskeleton Organization Small GTPase-mediated Signal Transduction Cell Junction Assembly Neuron Fate Determination Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Establishment Of Golgi Localization Establishment Of Organelle Localization Neuropilin Signaling Pathway Postsynapse Regulation Of Synapse Organization GBD Domain Binding Golgi Transport Complex Storage Vacuole Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Regulation Of Cell-substrate Adhesion CENP-A Containing Chromatin CENP-A Containing Chromatin Assembly Kinetochore Assembly Transcription Elongation Factor Activity Ubiquitin-like Protein Conjugating Enzyme Binding Regulation Of Cell Junction Assembly Arp2/3 Complex Binding Regulation Of Cellular Component Organization Proline-rich Region Binding Cell Projection Regulation Of Actin Cytoskeleton Organization Cell Projection Assembly Cardiac Conduction System Development	Chromosome Protein Localization To Chromosome NAD+-protein-serine ADP-ribosyltransferase Activity Protein Localization To Organelle DNA ADP-ribosylation NAD DNA ADP-ribosyltransferase Activity Protein Localization To Chromatin Chromosome Passenger Complex Mitotic Spindle Midzone Assembly Organelle Organization Cellular Response To UV Protein Auto-ADP-ribosylation NAD+-protein-glutamate ADP-ribosyltransferase Activity Spindle Midzone Assembly NAD+-protein-aspartate ADP-ribosyltransferase Activity Chromatin Remodeling Cellular Response To Light Stimulus Negative Regulation Of CGAS/STING Signaling Pathway Protein Poly-ADP-ribosylation Telomere Organization NAD+-protein Mono-ADP-ribosyltransferase Activity Chromatin Organization Post-translational Protein Modification Decidualization DNA Repair-dependent Chromatin Remodeling DNA Modification Response To UV NAD+ Poly-ADP-ribosyltransferase Activity Chromosome, Centromeric Region Protein Serine/threonine/tyrosine Kinase Activity Spindle Midzone Kinetochore Cellular Response To Radiation Nucleolus Actin Filament Polymerization Nucleosome Binding Protein Modification Process Attachment Of Spindle Microtubules To Kinetochore Positive Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Immune System Process Protein Localization To Chromosome, Centromeric Region Negative Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Spindle Microtubule Site Of DNA Damage Positive Regulation Of Cytokinesis Intracellular Protein Localization Nucleus Spindle Positive Regulation Of Cell Cycle Process NAD+-histone H3S10 Serine ADP-ribosyltransferase Activity
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