NFASC and SCN1B

Number of citations of the paper that reports this interaction (PMID 11470829)
35

Data Source:
HPRD (in vivo)

		NFASC	SCN1B
Gene Name		neurofascin	sodium channel, voltage gated, type I beta subunit
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Intracellular Plasma Membrane Focal Adhesion Integral Component Of Membrane Paranodal Junction Node Of Ranvier Paranode Region Of Axon Axon Initial Segment Extracellular Vesicular Exosome	Voltage-gated Sodium Channel Complex Extracellular Region Intercalated Disc T-tubule Node Of Ranvier
	Molecular Function	Protein Binding Protein Binding Involved In Heterotypic Cell-cell Adhesion	Voltage-gated Sodium Channel Activity Sodium Channel Regulator Activity Sodium Channel Inhibitor Activity Voltage-gated Sodium Channel Activity Involved In Cardiac Muscle Cell Action Potential Voltage-gated Sodium Channel Activity Involved In Purkinje Myocyte Action Potential
	Biological Process	Protein Localization To Paranode Region Of Axon Axon Guidance Peripheral Nervous System Development Transmission Of Nerve Impulse Paranodal Junction Assembly Heterotypic Cell-cell Adhesion Myelination Clustering Of Voltage-gated Sodium Channels Synapse Organization Protein Localization To Juxtaparanode Region Of Axon	Cell Adhesion Synaptic Transmission Axon Guidance Positive Regulation Of Sodium Ion Transport Positive Regulation Of Neuron Projection Development Neuronal Action Potential Propagation Corticospinal Neuron Axon Guidance Sodium Ion Transmembrane Transport Locomotion Response To Pyrethroid Membrane Depolarization Cardiac Muscle Contraction Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization Cardiac Conduction Cardiac Muscle Cell Action Potential Involved In Contraction Membrane Depolarization During Cardiac Muscle Cell Action Potential Membrane Depolarization During Purkinje Myocyte Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Regulation Of Sodium Ion Transmembrane Transporter Activity
Pathways		Interaction between L1 and Ankyrins Axon guidance Neurofascin interactions L1CAM interactions	Interaction between L1 and Ankyrins Axon guidance L1CAM interactions
Drugs
Diseases
GWAS		Dental caries ( 23064961)	Serum albumin level ( 23022100)
Protein-Protein Interactions		10 interactors: ANK1 CNTNAP1 DCX NRCAM SCN1B SCN3B SCNN1B SDCBP SDCBP2 TNR	3 interactors: ANK3 NFASC SCN2B
Entrez ID		23114	6324
HPRD ID		12372	02581
Ensembl ID		ENSG00000163531	ENSG00000105711
Uniprot IDs		B4DRH7 O94856	B4DI92 Q07699
PDB IDs		3P3Y 3P40
Enriched GO Terms of Interacting Partners?		Axon Guidance Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Neuron Projection Morphogenesis Cell Morphogenesis Involved In Differentiation Neuronal Action Potential Propagation Neuron Projection Development Nervous System Development Cell Projection Morphogenesis Cell Part Morphogenesis Neuron Development Cell Morphogenesis Neuron Differentiation Cell Projection Organization Locomotion Movement Of Cell Or Subcellular Component Generation Of Neurons Neurogenesis System Development Transmission Of Nerve Impulse Cell Development Response To External Stimulus Neurological System Process Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization Multicellular Organismal Development Anatomical Structure Development Membrane Depolarization During Cardiac Muscle Cell Action Potential Anatomical Structure Morphogenesis Developmental Process Cell-cell Signaling Involved In Cardiac Conduction Regulation Of Heart Rate By Cardiac Conduction Cardiac Muscle Cell Action Potential Involved In Contraction Regulation Of Sodium Ion Transmembrane Transporter Activity Sodium Ion Transmembrane Transport Membrane Depolarization During Action Potential Regulation Of Membrane Depolarization Cardiac Muscle Cell Action Potential Cell Differentiation Regulation Of Sodium Ion Transmembrane Transport Positive Regulation Of Sodium Ion Transport Monovalent Inorganic Cation Transport Central Nervous System Projection Neuron Axonogenesis Sodium Ion Transport Regulation Of Cardiac Muscle Cell Contraction Cardiac Conduction Cardiac Muscle Contraction Cell Migration Signaling	Regulation Of Sodium Ion Transmembrane Transporter Activity Regulation Of Membrane Depolarization Regulation Of Sodium Ion Transmembrane Transport Transmission Of Nerve Impulse Regulation Of Sodium Ion Transport Action Potential Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Maintenance Of Protein Location In Plasma Membrane Positive Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Regulation Of Ion Homeostasis Synapse Organization Negative Regulation Of Delayed Rectifier Potassium Channel Activity Positive Regulation Of Cell Communication By Electrical Coupling Regulation Of Membrane Potential Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Cellular Response To Magnesium Ion Response To Pyrethroid Regulation Of Membrane Depolarization During Action Potential Axon Guidance Clustering Of Voltage-gated Sodium Channels Regulation Of Cardiac Muscle Cell Action Potential Nervous System Development Regulation Of Ion Transmembrane Transport Regulation Of Delayed Rectifier Potassium Channel Activity Positive Regulation Of Action Potential Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Regulation Of Cell Communication By Electrical Coupling Neuronal Ion Channel Clustering Protein Localization To Paranode Region Of Axon Cytoskeletal Anchoring At Plasma Membrane Protein Localization To Juxtaparanode Region Of Axon Axonogenesis Positive Regulation Of Sodium Ion Transmembrane Transporter Activity Membrane Depolarization During Cardiac Muscle Cell Action Potential Axon Development Negative Regulation Of Potassium Ion Transmembrane Transport Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Positive Regulation Of Sodium Ion Transmembrane Transport Regulation Of Ion Transport Magnesium Ion Homeostasis Paranodal Junction Assembly Neuron Projection Morphogenesis Response To Insecticide Response To Magnesium Ion Negative Regulation Of Cation Channel Activity Cell Morphogenesis Involved In Differentiation Heterotypic Cell-cell Adhesion
Tagcloud ?			adam19 atria conduction connexins coq7 cx40 dyrk1a electrocardiogram f5 gabpa hmgn1 lethality monosomic morc3 ms5yah natal ncx1 pde10a pinpoint precordial scn10a scn5a slc5a3 slc8a1 tfb1m tiam1 trisomic ts65dn ventricles
Tagcloud (Difference) ?			adam19 atria conduction connexins coq7 cx40 dyrk1a electrocardiogram f5 gabpa hmgn1 lethality monosomic morc3 ms5yah natal ncx1 pde10a pinpoint precordial scn10a scn5a slc5a3 slc8a1 tfb1m tiam1 trisomic ts65dn ventricles
Tagcloud (Intersection) ?