NFASC and NRCAM

Number of citations of the paper that reports this interaction (PMID 11724816)
95

Data Source:
HPRD (in vivo)

		NFASC	NRCAM
Gene Name		neurofascin	neuronal cell adhesion molecule
Image
Gene Ontology Annotations	Cellular Component	Intracellular Plasma Membrane Focal Adhesion Integral Component Of Membrane Paranodal Junction Node Of Ranvier Paranode Region Of Axon Axon Initial Segment Extracellular Vesicular Exosome	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Neuron Projection Axon Initial Segment Synapse
	Molecular Function	Protein Binding Protein Binding Involved In Heterotypic Cell-cell Adhesion	Protein Binding Ankyrin Binding Protein Binding Involved In Heterotypic Cell-cell Adhesion
	Biological Process	Protein Localization To Paranode Region Of Axon Axon Guidance Peripheral Nervous System Development Transmission Of Nerve Impulse Paranodal Junction Assembly Heterotypic Cell-cell Adhesion Myelination Clustering Of Voltage-gated Sodium Channels Synapse Organization Protein Localization To Juxtaparanode Region Of Axon	Angiogenesis Neuron Migration Axonogenesis Axon Guidance Axonal Fasciculation Synapse Assembly Central Nervous System Development Protein Localization Single Organismal Cell-cell Adhesion Neuronal Action Potential Propagation Regulation Of Axon Extension Retinal Ganglion Cell Axon Guidance Heterotypic Cell-cell Adhesion Clustering Of Voltage-gated Sodium Channels Positive Regulation Of Neuron Differentiation
Pathways		Interaction between L1 and Ankyrins Axon guidance Neurofascin interactions L1CAM interactions	Interaction between L1 and Ankyrins Axon guidance Neurofascin interactions L1CAM interactions NrCAM interactions
Drugs
Diseases
GWAS		Dental caries ( 23064961)	Coffee consumption ( 21876539) Femoral neck bone geometry and menarche (age at onset) ( 23593202)
Protein-Protein Interactions		10 interactors: ANK1 CNTNAP1 DCX NRCAM SCN1B SCN3B SCNN1B SDCBP SDCBP2 TNR	8 interactors: ANK2 CNTN2 HSPA12A LNX1 MACF1 MAGI3 NFASC PTPRB
Entrez ID		23114	4897
HPRD ID		12372	07207
Ensembl ID		ENSG00000163531	ENSG00000091129
Uniprot IDs		B4DRH7 O94856	B7Z670 Q14CA1 Q92823
PDB IDs		3P3Y 3P40	1UEN 1UEY
Enriched GO Terms of Interacting Partners?		Axon Guidance Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Neuron Projection Morphogenesis Cell Morphogenesis Involved In Differentiation Neuronal Action Potential Propagation Neuron Projection Development Nervous System Development Cell Projection Morphogenesis Cell Part Morphogenesis Neuron Development Cell Morphogenesis Neuron Differentiation Cell Projection Organization Locomotion Movement Of Cell Or Subcellular Component Generation Of Neurons Neurogenesis System Development Transmission Of Nerve Impulse Cell Development Response To External Stimulus Neurological System Process Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization Multicellular Organismal Development Anatomical Structure Development Membrane Depolarization During Cardiac Muscle Cell Action Potential Anatomical Structure Morphogenesis Developmental Process Cell-cell Signaling Involved In Cardiac Conduction Regulation Of Heart Rate By Cardiac Conduction Cardiac Muscle Cell Action Potential Involved In Contraction Regulation Of Sodium Ion Transmembrane Transporter Activity Sodium Ion Transmembrane Transport Membrane Depolarization During Action Potential Regulation Of Membrane Depolarization Cardiac Muscle Cell Action Potential Cell Differentiation Regulation Of Sodium Ion Transmembrane Transport Positive Regulation Of Sodium Ion Transport Monovalent Inorganic Cation Transport Central Nervous System Projection Neuron Axonogenesis Sodium Ion Transport Regulation Of Cardiac Muscle Cell Contraction Cardiac Conduction Cardiac Muscle Contraction Cell Migration Signaling	Protein Localization To Juxtaparanode Region Of Axon Neuronal Ion Channel Clustering Paranodal Junction Assembly Myelination Axon Ensheathment Neuron Maturation Myelin Assembly Membrane Organization Axon Guidance Anatomical Structure Formation Involved In Morphogenesis Establishment Of Protein Localization To Plasma Membrane Establishment Of Protein Localization To Juxtaparanode Region Of Axon Protein Localization To T-tubule Anatomical Structure Morphogenesis Axonogenesis Cellular Protein Localization Protein Localization To M-band Positive Regulation Of Adenosine Receptor Signaling Pathway T-tubule Organization Cell-cell Junction Assembly Axon Development Cell Morphogenesis Involved In Neuron Differentiation Protein Localization To Endoplasmic Reticulum Chemotaxis Movement Of Cell Or Subcellular Component Neuron Projection Morphogenesis Clustering Of Voltage-gated Potassium Channels Generation Of Neurons Cell Maturation Protein Localization To Plasma Membrane Regulation Of Axonogenesis Protein Targeting To Membrane Neurogenesis Cell Morphogenesis Involved In Differentiation Membrane Depolarization During SA Node Cell Action Potential Cell Junction Assembly SA Node Cell Action Potential Neuron Projection Development Cell-cell Junction Organization Cell Projection Morphogenesis Clustering Of Voltage-gated Sodium Channels Regulation Of Axon Diameter Protein Localization Cell Part Morphogenesis Plasma Membrane Organization Posttranslational Protein Targeting To Membrane Regulation Of Cardiac Muscle Cell Membrane Potential Establishment Of Protein Localization To Membrane Cerebral Cortex GABAergic Interneuron Migration Atrial Cardiac Muscle Cell Action Potential
Tagcloud ?			affects clustering disorganization dorsal erbb2 erbb3 ganglion glaucoma gliomedin implicate littermates myelin myelination myocilin nav1 nerve nerves neurofascin nodal nodes null ocular ranvier root schwann sciatic sheath stimulates thickness
Tagcloud (Difference) ?			affects clustering disorganization dorsal erbb2 erbb3 ganglion glaucoma gliomedin implicate littermates myelin myelination myocilin nav1 nerve nerves neurofascin nodal nodes null ocular ranvier root schwann sciatic sheath stimulates thickness
Tagcloud (Intersection) ?