NFASC and SCNN1B

Number of citations of the paper that reports this interaction (PMID 11470829)
35

Data Source:
HPRD (in vivo)

		NFASC	SCNN1B
Gene Name		neurofascin	sodium channel, non voltage gated 1 beta subunit
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Intracellular Plasma Membrane Focal Adhesion Integral Component Of Membrane Paranodal Junction Node Of Ranvier Paranode Region Of Axon Axon Initial Segment Extracellular Vesicular Exosome	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Apical Plasma Membrane Sodium Channel Complex Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Protein Binding Involved In Heterotypic Cell-cell Adhesion	Protein Binding Ligand-gated Sodium Channel Activity WW Domain Binding
	Biological Process	Protein Localization To Paranode Region Of Axon Axon Guidance Peripheral Nervous System Development Transmission Of Nerve Impulse Paranodal Junction Assembly Heterotypic Cell-cell Adhesion Myelination Clustering Of Voltage-gated Sodium Channels Synapse Organization Protein Localization To Juxtaparanode Region Of Axon	Sodium Ion Transport Excretion Ion Transmembrane Transport Sodium Ion Transmembrane Transport Multicellular Organismal Water Homeostasis Response To Stimulus Sensory Perception Of Taste Sodium Ion Homeostasis Transmembrane Transport
Pathways		Interaction between L1 and Ankyrins Axon guidance Neurofascin interactions L1CAM interactions	Ion channel transport Stimuli-sensing channels
Drugs			Triamterene Amiloride
Diseases
GWAS		Dental caries ( 23064961)
Protein-Protein Interactions		10 interactors: ANK1 CNTNAP1 DCX NRCAM SCN1B SCN3B SCNN1B SDCBP SDCBP2 TNR	13 interactors: ANK3 CNTN1 EPN1 HECW1 ITCH NEDD4 NEDD4L NFASC SCNN1A SCNN1D SCNN1G STX1A WWP2
Entrez ID		23114	6338
HPRD ID		12372	02861
Ensembl ID		ENSG00000163531	ENSG00000168447
Uniprot IDs		B4DRH7 O94856	B2R812 P51168
PDB IDs		3P3Y 3P40
Enriched GO Terms of Interacting Partners?		Axon Guidance Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Neuron Projection Morphogenesis Cell Morphogenesis Involved In Differentiation Neuronal Action Potential Propagation Neuron Projection Development Nervous System Development Cell Projection Morphogenesis Cell Part Morphogenesis Neuron Development Cell Morphogenesis Neuron Differentiation Cell Projection Organization Locomotion Movement Of Cell Or Subcellular Component Generation Of Neurons Neurogenesis System Development Transmission Of Nerve Impulse Cell Development Response To External Stimulus Neurological System Process Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization Multicellular Organismal Development Anatomical Structure Development Membrane Depolarization During Cardiac Muscle Cell Action Potential Anatomical Structure Morphogenesis Developmental Process Cell-cell Signaling Involved In Cardiac Conduction Regulation Of Heart Rate By Cardiac Conduction Cardiac Muscle Cell Action Potential Involved In Contraction Regulation Of Sodium Ion Transmembrane Transporter Activity Sodium Ion Transmembrane Transport Membrane Depolarization During Action Potential Regulation Of Membrane Depolarization Cardiac Muscle Cell Action Potential Cell Differentiation Regulation Of Sodium Ion Transmembrane Transport Positive Regulation Of Sodium Ion Transport Monovalent Inorganic Cation Transport Central Nervous System Projection Neuron Axonogenesis Sodium Ion Transport Regulation Of Cardiac Muscle Cell Contraction Cardiac Conduction Cardiac Muscle Contraction Cell Migration Signaling	Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Potassium Ion Transmembrane Transporter Activity Regulation Of Potassium Ion Transmembrane Transport Regulation Of Potassium Ion Transport Regulation Of Sodium Ion Transport Regulation Of Membrane Potential Sodium Ion Homeostasis Protein K63-linked Ubiquitination Positive Regulation Of Sodium Ion Transport Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Negative Regulation Of Transporter Activity Protein Polyubiquitination Excretion Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Water Homeostasis Sensory Perception Of Taste Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Sodium Ion Transport Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Catabolic Process Regulation Of Ion Transport Negative Regulation Of Sodium Ion Transport Negative Regulation Of Ion Transport Negative Regulation Of Potassium Ion Transmembrane Transport Interaction With Host Locomotion Positive Regulation Of Transport Negative Regulation Of Transport Notch Signaling Pathway Negative Regulation Of Potassium Ion Transport Cellular Macromolecule Catabolic Process Regulation Of Ion Transmembrane Transport Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Synapse Organization Metal Ion Homeostasis Regulation Of Sodium Ion Transmembrane Transporter Activity Viral Life Cycle Positive Regulation Of Ion Transport Sodium Ion Transmembrane Transport Viral Process Regulation Of Membrane Depolarization Regulation Of Sodium Ion Transmembrane Transport Negative Regulation Of Signal Transduction Ion Homeostasis Protein K48-linked Ubiquitination
Tagcloud ?			aldosterone atp1a1 atpasealpha1 betamethasone breaths compliance corticosteroid corticosteroids elastin enac enacalpha enacbeta epithelia fetuses gestation gr inflation infused infusions intravenously mineralocorticoid mr ovine pressures reabsorption stepwise synergy transcriptomic
Tagcloud (Difference) ?			aldosterone atp1a1 atpasealpha1 betamethasone breaths compliance corticosteroid corticosteroids elastin enac enacalpha enacbeta epithelia fetuses gestation gr inflation infused infusions intravenously mineralocorticoid mr ovine pressures reabsorption stepwise synergy transcriptomic
Tagcloud (Intersection) ?