DAPK3 and NEDD4L

Number of citations: 60 (PubMedID 19953087)
Data Source: BioGRID (enzymatic study)

		DAPK3	NEDD4L
Name		death associated protein kinase 3	NEDD4 like E3 ubiquitin protein ligase
Structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Nucleus Nucleoplasm Chromosome Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Cilium PML Body Midbody	Nucleoplasm Cytoplasm Endosome Multivesicular Body Golgi Apparatus Cytosol Plasma Membrane Apical Plasma Membrane Extracellular Exosome
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding CAMP Response Element Binding Protein Binding Kinase Activity Transferase Activity Small GTPase Binding Identical Protein Binding Protein Homodimerization Activity Leucine Zipper Domain Binding Protein Serine Kinase Activity	Ubiquitin-protein Transferase Activity Protein Binding Transferase Activity Sodium Channel Regulator Activity Potassium Channel Inhibitor Activity Sodium Channel Inhibitor Activity Transmembrane Transporter Binding Ubiquitin Protein Ligase Activity
	Biological Process	Chromatin Organization Regulation Of DNA-templated Transcription Regulation Of Translation Protein Phosphorylation Apoptotic Process Regulation Of Smooth Muscle Contraction Regulation Of Mitotic Nuclear Division Regulation Of Mitotic Cell Cycle Regulation Of Cell Shape Regulation Of Autophagy Negative Regulation Of Translation Positive Regulation Of Cell Migration Regulation Of Actin Cytoskeleton Organization Intracellular Signal Transduction Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Regulation Of Myosin II Filament Organization Protein Autophosphorylation Regulation Of Focal Adhesion Assembly Cellular Response To Type II Interferon Positive Regulation Of Canonical Wnt Signaling Pathway Apoptotic Signaling Pathway Regulation Of Cell Motility	Regulation Of Membrane Depolarization Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Monoatomic Ion Transport Neuromuscular Junction Development Protein Ubiquitination Cell Differentiation Neuron Projection Development Receptor Internalization Regulation Of Protein Stability Receptor Catabolic Process Monoatomic Ion Transmembrane Transport Regulation Of Membrane Potential Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of Dendrite Morphogenesis Regulation Of Synapse Organization Regulation Of Membrane Repolarization Regulation Of Biological Quality Protein K48-linked Ubiquitination Ventricular Cardiac Muscle Cell Action Potential Sodium Ion Import Across Plasma Membrane Negative Regulation Of Potassium Ion Transmembrane Transport Regulation Of Sodium Ion Transmembrane Transport Negative Regulation Of Sodium Ion Transmembrane Transport Negative Regulation Of Potassium Ion Export Across Plasma Membrane Negative Regulation Of Sodium Ion Import Across Plasma Membrane Positive Regulation Of Dendrite Extension Negative Regulation Of Protein Localization To Cell Surface Positive Regulation Of Caveolin-mediated Endocytosis
Pathways		Caspase activation via Dependence Receptors in the absence of ligand	Budding and maturation of HIV virion Downregulation of TGF-beta receptor signaling Downregulation of SMAD2/3:SMAD4 transcriptional activity Stimuli-sensing channels Antigen processing: Ubiquitination & Proteasome degradation
Drugs		2-tert-butyl-9-fluoro-1,6-dihydrobenzo[h]imidazo[4,5-f]isoquinolin-7-one 4-(6-{[(1R)-1-(hydroxymethyl)propyl]amino}imidazo[1,2-b]pyridazin-3-yl)benzoic acid (4R)-7,8-dichloro-1',9-dimethyl-1-oxo-1,2,4,9-tetrahydrospiro[beta-carboline-3,4'-piperidine]-4-carbonitrile Fostamatinib	None
GWAS		Age-related macular degeneration ( 23326517 ) Expressive vocabulary in infants ( 25226531 )	Alanine aminotransferase levels ( 34315874 33547301 ) Amyotrophic lateral sclerosis (sporadic) ( 24529757 ) Aspartate aminotransferase levels ( 34315874 33547301 ) Childhood body mass index ( 33045005 ) Diastolic blood pressure ( 30224653 ) Diisocyanate-induced asthma ( 25918132 ) Gamma glutamyl transferase levels ( 33339817 29403010 ) Insomnia (caffeine-induced) ( 22754043 ) Liver enzyme levels (alanine transaminase) ( 33972514 ) Liver enzyme levels (alkaline phosphatase) ( 33972514 ) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757 33972514 ) Manganese levels ( 26025379 ) Response to amphetamines ( 22952603 ) Serum alkaline phosphatase levels ( 33339817 33547301 )
Interacting Genes		18 interacting genes: AATF AK3 ANXA1 ATF4 CDKN1A CHEK2 DAXX GRB14 LMO7 MDM2 MET NEDD4L OGT PAWR PRKCZ RPL34 TCP10L TP53	151 interacting genes: AATF ABL1 ABL2 ACVR1B ACY3 ADAP2 AICDA AKT1 AKT3 AMOT APEX2 ARHGDIA ARRB1 ARRB2 AURKC BBX BMPR1A CACNB1 CAMK1D CDC34 CDK3 CDK5 CEP55 CHLSN CLIC2 CUEDC1 CYBRD1 CYP26B1 DAPK3 DAZAP2 DDX54 DECR2 DMTN DYRK3 EFEMP2 FGF12 FKBP3 FOXO1 GORAB GRIA1 H1-0 HAX1 HNRNPD HSPA5 IFRD2 IKBKB IL6ST KCNAB1 KCNAB2 KCNAB3 KCNB1 KIF3B KIFC3 LAPTM5 MAGEB1 MAP1LC3A MAP2 MAP3K20 MAP3K3 MAP3K5 MAPKAPK3 MARK2 MERTK MINK1 MOB3A MRPL19 NDFIP2 NEAT1 NEIL3 NHP2 NR3C1 NSRP1 NTRK1 NUDT16L1 OGG1 PBX1 PDCD6IP PIP4P2 PRKX PRR16 PRRG1 PRRG2 PSMD4 PTGR3 PYM1 RANBP10 RASL10B RASL11B RHOB RNF11 RNF7 ROBO3 RPL30 RPS6KB2 SCAMP3 SCD SCN5A SCNN1A SCNN1B SCNN1G SENP2 SERPINF1 SGK1 SGK2 SIVA1 SLC7A7 SLC9A3 SMAD2 SMAD3 SMAD7 SNCA SP1 SPAG8 SRMS STAC STK40 TAF1B TARBP2 TBC1D7 TCEAL2 TGFB1I1 TMA16 TRAF3 TRIM41 UBAC1 UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2E3 UBE2J2 UBE2K UBE2L3 UBE2L6 UBE2N ULK1 USP7 VDAC2 WBP2 WNK4 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ YY1 ZC3HAV1L ZDHHC3
Entrez ID		1613	23327
HPRD ID		04478	05903
Ensembl ID		ENSG00000167657	ENSG00000049759
Uniprot IDs		B3KNJ3 O43293	A0A1B0GVY1 B7Z2P9 B7Z6K0 Q96PU5
PDB IDs		1YRP 2J90 3BHY 3BQR 5A6N 5A6O 5VJA	2LAJ 2LB2 2LTY 2MPT 2NSQ 2ONI 3JVZ 3JW0 5HPK 6ZBT 6ZC9 7LP1 7LP2 7LP3 7LP4 7LP5 7NMZ
GO Terms Enriched among Interactors		Regulation Of Programmed Cell Death Cellular Response To Gamma Radiation Leucine Zipper Domain Binding DNA Damage Response, Signal Transduction By P53 Class Mediator Response To Gamma Radiation Negative Regulation Of Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Cellular Response To Radiation Negative Regulation Of Cell Communication Intrinsic Apoptotic Signaling Pathway Apoptotic Signaling Pathway Regulation Of Protein Metabolic Process Negative Regulation Of Signaling Replicative Senescence Cellular Response To Ionizing Radiation Cellular Response To UV Molecular Function Activator Activity Positive Regulation Of Metabolic Process Cellular Response To Actinomycin D Signal Transduction By P53 Class Mediator Regulation Of Apoptotic Process Cellular Response To Light Stimulus Cellular Response To Nutrient Levels Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Response To Actinomycin D Response To Nutrient Levels Negative Regulation Of Gene Expression Regulation Of Mitotic Cell Cycle Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Cellular Response To UV-C Ubiquitin Protein Ligase Binding Response To Ionizing Radiation Positive Regulation Of Biosynthetic Process Positive Regulation Of Programmed Cell Death Regulation Of Macromolecule Biosynthetic Process Signal Transduction In Response To DNA Damage Response To UV Negative Regulation Of Metabolic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Programmed Cell Death Regulation Of Primary Metabolic Process Negative Regulation Of Protein Metabolic Process Stress-induced Premature Senescence Regulation Of Signaling Negative Regulation Of Biosynthetic Process Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Metabolic Process Regulation Of Cell Cycle G1/S Phase Transition	Ubiquitin Conjugating Enzyme Activity Protein Kinase Activity ATP Binding Protein Serine/threonine Kinase Activity Protein Modification Process Ubiquitin Protein Ligase Binding Kinase Activity Nucleotide Binding Protein Serine Kinase Activity Protein Phosphorylation Transferase Activity Phosphorylation Intracellular Signal Transduction Regulation Of Signal Transduction Regulation Of Cell Communication Protein Polyubiquitination Protein Metabolic Process Regulation Of Signaling Protein Ubiquitination Protein Modification By Small Protein Conjugation Cytosol Macromolecule Metabolic Process Modification-dependent Protein Catabolic Process Cellular Response To Nutrient Levels Proteolysis Involved In Protein Catabolic Process Response To Nutrient Levels Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Cytoplasm Regulation Of Transport Protein Autophosphorylation Cellular Response To Oxygen-containing Compound Protein Domain Specific Binding Regulation Of TORC1 Signaling Regulation Of Protein Ubiquitination Transmembrane Transporter Binding Protein K11-linked Ubiquitination Signal Transduction Negative Regulation Of Signaling Negative Regulation Of Cell Communication TORC1 Signaling Protein Sequestering Activity Macromolecule Catabolic Process Nucleus Regulation Of TOR Signaling Negative Regulation Of TORC1 Signaling Potassium Channel Regulator Activity Regulation Of Intracellular Signal Transduction MAPK Cascade Negative Regulation Of Signal Transduction