DAPK3 and AK3

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		DAPK3	AK3
Description		death associated protein kinase 3	adenylate kinase 3
Image
GO Annotations	Cellular Component	Chromosome, Centromeric Region Nucleus Nucleoplasm Chromosome Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Cilium PML Body Midbody	Cytoplasm Mitochondrion Mitochondrial Matrix
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding CAMP Response Element Binding Protein Binding Kinase Activity Transferase Activity Small GTPase Binding Identical Protein Binding Protein Homodimerization Activity Leucine Zipper Domain Binding Protein Serine Kinase Activity	Nucleotide Binding AMP Kinase Activity Protein Binding ATP Binding GTP Binding Kinase Activity Transferase Activity Phosphotransferase Activity, Phosphate Group As Acceptor Ligase Activity Nucleobase-containing Compound Kinase Activity Nucleoside Triphosphate Adenylate Kinase Activity
	Biological Process	Chromatin Organization Regulation Of DNA-templated Transcription Regulation Of Translation Protein Phosphorylation Apoptotic Process Regulation Of Smooth Muscle Contraction Regulation Of Mitotic Nuclear Division Regulation Of Mitotic Cell Cycle Regulation Of Cell Shape Regulation Of Autophagy Negative Regulation Of Translation Positive Regulation Of Cell Migration Regulation Of Actin Cytoskeleton Organization Intracellular Signal Transduction Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Regulation Of Myosin II Filament Organization Protein Autophosphorylation Regulation Of Focal Adhesion Assembly Cellular Response To Type II Interferon Positive Regulation Of Canonical Wnt Signaling Pathway Apoptotic Signaling Pathway Regulation Of Cell Motility	Nucleobase-containing Compound Metabolic Process ADP Biosynthetic Process Blood Coagulation Nucleotide Metabolic Process Nucleoside Monophosphate Metabolic Process Nucleoside Triphosphate Biosynthetic Process AMP Metabolic Process GTP Metabolic Process ITP Metabolic Process UTP Metabolic Process
Pathways		Caspase activation via Dependence Receptors in the absence of ligand	Factors involved in megakaryocyte development and platelet production
Drugs		2-tert-butyl-9-fluoro-1,6-dihydrobenzo[h]imidazo[4,5-f]isoquinolin-7-one 4-(6-{[(1R)-1-(hydroxymethyl)propyl]amino}imidazo[1,2-b]pyridazin-3-yl)benzoic acid (4R)-7,8-dichloro-1',9-dimethyl-1-oxo-1,2,4,9-tetrahydrospiro[beta-carboline-3,4'-piperidine]-4-carbonitrile Fostamatinib
Diseases
GWAS		Age-related macular degeneration ( 23326517) Expressive vocabulary in infants ( 25226531)	Crohn's disease ( 22412388) Hematological parameters ( 19820697) Mean corpuscular hemoglobin ( 27863252) Mean spheric corpuscular volume ( 32888494) Platelet count ( 20139978 22139419 26805783 29403010) Schizophrenia, bipolar disorder or major depressive disorder x sex interaction (3df) ( 34099189) White blood cell count ( 27863252)
Interacting Genes		18 interacting genes: AATF AK3 ANXA1 ATF4 CDKN1A CHEK2 DAXX GRB14 LMO7 MDM2 MET NEDD4L OGT PAWR PRKCZ RPL34 TCP10L TP53	6 interacting genes: APPBP2 DAPK3 FBLN1 KRTAP10-8 TRIM54 ZDHHC17
Entrez ID		1613	50808
HPRD ID		04478	12439
Ensembl ID		ENSG00000167657	ENSG00000147853
Uniprot IDs		B3KNJ3 O43293	Q7Z4Y4 Q9UIJ7
PDB IDs		1YRP 2J90 3BHY 3BQR 5A6N 5A6O 5VJA	1ZD8 6ZJB 6ZJD 6ZJE
Enriched GO Terms of Interacting Partners?		Regulation Of Programmed Cell Death Cellular Response To Gamma Radiation Leucine Zipper Domain Binding DNA Damage Response, Signal Transduction By P53 Class Mediator Response To Gamma Radiation Negative Regulation Of Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Cellular Response To Radiation Negative Regulation Of Cell Communication Intrinsic Apoptotic Signaling Pathway Apoptotic Signaling Pathway Regulation Of Protein Metabolic Process Negative Regulation Of Signaling Replicative Senescence Cellular Response To Ionizing Radiation Cellular Response To UV Molecular Function Activator Activity Positive Regulation Of Metabolic Process Cellular Response To Actinomycin D Signal Transduction By P53 Class Mediator Regulation Of Apoptotic Process Cellular Response To Light Stimulus Cellular Response To Nutrient Levels Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Response To Actinomycin D Response To Nutrient Levels Negative Regulation Of Gene Expression Regulation Of Mitotic Cell Cycle Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Cellular Response To UV-C Ubiquitin Protein Ligase Binding Response To Ionizing Radiation Positive Regulation Of Biosynthetic Process Positive Regulation Of Programmed Cell Death Regulation Of Macromolecule Biosynthetic Process Signal Transduction In Response To DNA Damage Response To UV Negative Regulation Of Metabolic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Programmed Cell Death Regulation Of Primary Metabolic Process Negative Regulation Of Protein Metabolic Process Stress-induced Premature Senescence Regulation Of Signaling Negative Regulation Of Biosynthetic Process Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Metabolic Process Regulation Of Cell Cycle G1/S Phase Transition
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