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AP2A2 and NUMB
Number of citations of the paper that reports this interaction (PubMedID
17203073
)
47
Data Source:
HPRD
(in vivo)
AP2A2
NUMB
Description
adaptor related protein complex 2 subunit alpha 2
NUMB endocytic adaptor protein
Image
No pdb structure
GO Annotations
Cellular Component
Cytosol
Plasma Membrane
Clathrin-coated Pit
Cytoplasmic Side Of Plasma Membrane
Membrane
Membrane Coat
AP-2 Adaptor Complex
Clathrin Adaptor Complex
Endocytic Vesicle Membrane
Secretory Granule Membrane
Clathrin-coated Endocytic Vesicle Membrane
Cytoplasmic Vesicle
Endolysosome Membrane
Clathrin-coated Endocytic Vesicle
Presynapse
Postsynapse
Ficolin-1-rich Granule Membrane
Cytoplasm
Endosome
Early Endosome
Plasma Membrane
Clathrin-coated Pit
Focal Adhesion
Endosome Membrane
Membrane
Basolateral Plasma Membrane
Clathrin-coated Vesicle
Cytoplasmic Vesicle
Apical Part Of Cell
Glutamatergic Synapse
Molecular Function
Protein Binding
Lipid Binding
Kinase Binding
Protein Kinase Binding
Protein Domain Specific Binding
Clathrin Adaptor Activity
Disordered Domain Specific Binding
Protein Binding
Beta-catenin Binding
Alpha-catenin Binding
Cadherin Binding
Biological Process
Intracellular Protein Transport
Endocytosis
Protein Transport
Vesicle-mediated Transport
Synaptic Vesicle Endocytosis
Clathrin-dependent Endocytosis
Postsynaptic Neurotransmitter Receptor Internalization
Nervous System Development
Neuroblast Proliferation
Axonogenesis
Lateral Ventricle Development
Neuroblast Division In Subventricular Zone
Positive Regulation Of Cell Migration
Forebrain Development
Adherens Junction Organization
Positive Regulation Of Neurogenesis
Regulation Of Postsynaptic Neurotransmitter Receptor Internalization
Negative Regulation Of Protein Localization To Plasma Membrane
Pathways
Nef Mediated CD4 Down-regulation
Retrograde neurotrophin signalling
Retrograde neurotrophin signalling
Nef Mediated CD8 Down-regulation
MHC class II antigen presentation
EPH-ephrin mediated repulsion of cells
Recycling pathway of L1
Recycling pathway of L1
WNT5A-dependent internalization of FZD4
WNT5A-dependent internalization of FZD2, FZD5 and ROR2
Neutrophil degranulation
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
VLDLR internalisation and degradation
LDL clearance
Potential therapeutics for SARS
Activated NOTCH1 Transmits Signal to the Nucleus
Recycling pathway of L1
Degradation of GLI1 by the proteasome
Hedgehog 'on' state
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin
Drugs
Diseases
GWAS
Adult asthma (
27611488
)
Alzheimer's disease (
30636644
)
Alzheimer's disease (late onset) (
24162737
)
Asthma (
31959851
)
Chronic bronchitis and chronic obstructive pulmonary disease (
25241909
)
Nicotine withdrawal (
29532581
)
Nicotine withdrawal symptom count (
29532581
)
Bipolar disorder with mood-incongruent psychosis (
23092984
)
Coronary artery calcification (
17903303
)
Hemoglobin (
32888494
)
Macular thickness (
30535121
)
Multisite chronic pain (
31194737
33830993
)
White matter hyperintensity volume x hypertension interaction (2df) (
33293549
)
Interacting Genes
18 interacting genes:
AMPH
ANXA1
AP1S1
AP2B1
APP
BIN1
DNAJC6
DNM1
EPN1
EPS15
HTT
NLGN3
NUMB
SHC1
SLC2A8
SMAD1
SNAP91
UBC
38 interacting genes:
AP2A1
AP2A2
APP
DPYSL2
EAF1
EGFR
EPS15
FBXO7
FRS3
IQGAP1
IRS1
ITCH
ITGB2
ITGB3
ITGB5
L1CAM
LNX1
LNX2
MAPK8IP2
MDM2
NEDD4
NOTCH1
NRON
OLIG1
PALS1
PDZK1IP1
PRKCA
PRKCB
PRKCD
PRKCE
PRKCG
PRKCH
PRKCZ
PTEN
RPL3
SIAH1
SPANXN2
TERF2
Entrez ID
161
8650
HPRD ID
06256
04767
Ensembl ID
ENSG00000183020
ENSG00000133961
Uniprot IDs
O94973
P49757
PDB IDs
5NJJ
5NJK
Enriched GO Terms of Interacting Partners
?
Clathrin-coated Pit
Endocytosis
Import Into Cell
Vesicle-mediated Transport
Clathrin Binding
Receptor-mediated Endocytosis
Phospholipid Binding
Clathrin Coat Assembly
Extrinsic Component Of Presynaptic Endocytic Zone Membrane
Cytoplasmic Vesicle
Vesicle-mediated Transport In Synapse
Synaptic Vesicle Endocytosis
Presynaptic Endocytosis
Synaptic Vesicle
Regulation Of Endocytosis
Early Endosome
Clathrin-coated Vesicle
Regulation Of Vesicle-mediated Transport
Establishment Of Localization In Cell
Clathrin-dependent Endocytosis
Synapse
Regulation Of Receptor-mediated Endocytosis
Cellular Response To Growth Factor Stimulus
Endosome
Postsynaptic Neurotransmitter Receptor Internalization
Response To Growth Factor
Plasma Membrane
Postsynaptic Endocytic Zone
Cytoplasmic Vesicle Membrane
Intracellular Transport
Clathrin Heavy Chain Binding
Vesicle
Regulation Of Transport
AP-2 Adaptor Complex
Organelle Organization
Presynapse
Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel
Clathrin Adaptor Activity
Regulation Of Multicellular Organismal Development
Regulation Of Clathrin-dependent Endocytosis
Positive Regulation Of Cellular Component Organization
Cellular Localization
Negative Regulation Of Blood Circulation
Regulation Of Developmental Process
Insulin Receptor Binding
Membrane
Regulation Of Cellular Component Organization
Positive Regulation Of Transport
Membrane Coat
Chemical Synaptic Transmission
Diacylglycerol-dependent Serine/threonine Kinase Activity
Enzyme Binding
Plasma Membrane
Receptor Internalization
Positive Regulation Of Signaling
Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity
Protein Kinase C Signaling
Diacylglycerol-dependent, Calcium-independent Serine/threonine Kinase Activity
Protein-containing Complex
Positive Regulation Of Cell Communication
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Intracellular Signal Transduction
Apical Plasma Membrane
Positive Regulation Of Signal Transduction
Positive Regulation Of Superoxide Anion Generation
Regulation Of Superoxide Anion Generation
Regulation Of MAPK Cascade
Negative Regulation Of Apoptotic Process
Regulation Of Protein Localization
Regulation Of Signaling
Negative Regulation Of Programmed Cell Death
Endocytosis
Intracellular Signal Transduction
Regulation Of Biological Quality
Regulation Of Superoxide Metabolic Process
Postsynaptic Neurotransmitter Receptor Internalization
Positive Regulation Of MAPK Cascade
Regulation Of Apoptotic Process
Regulation Of Signal Transduction
Cell Activation
Negative Regulation Of Glial Cell Apoptotic Process
Ubiquitin-protein Transferase Activity
Regulation Of Cellular Component Organization
Regulation Of Programmed Cell Death
AP-2 Adaptor Complex
Positive Regulation Of Metabolic Process
Regulation Of Cell Communication
Receptor-mediated Endocytosis
Regulation Of Vesicle-mediated Transport
Apoptotic Process
Positive Regulation Of Catabolic Process
Extracellular Exosome
Signal Transduction
Positive Regulation Of ERK1 And ERK2 Cascade
Regulation Of Transport
Programmed Cell Death
Cell Death
Negative Regulation Of Insulin Receptor Signaling Pathway
Modulation Of Excitatory Postsynaptic Potential
Negative Regulation Of Cellular Response To Insulin Stimulus
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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