AP2A2 and ZPR1

		AP2A2	ZPR1
Description		adaptor related protein complex 2 subunit alpha 2	ZPR1 zinc finger
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Clathrin-coated Pit Cytoplasmic Side Of Plasma Membrane Membrane Membrane Coat AP-2 Adaptor Complex Clathrin Adaptor Complex Endocytic Vesicle Membrane Secretory Granule Membrane Clathrin-coated Endocytic Vesicle Membrane Cytoplasmic Vesicle Endolysosome Membrane Clathrin-coated Endocytic Vesicle Presynapse Postsynapse Ficolin-1-rich Granule Membrane	Nucleus Nucleoplasm Nucleolus Cytoplasm Cajal Body Axon Growth Cone Cell Projection Neuronal Cell Body Perikaryon Perinuclear Region Of Cytoplasm Gemini Of Cajal Bodies
	Molecular Function	Protein Binding Lipid Binding Kinase Binding Protein Kinase Binding Protein Domain Specific Binding Clathrin Adaptor Activity Disordered Domain Specific Binding	Protein Binding Zinc Ion Binding Receptor Tyrosine Kinase Binding Translation Initiation Factor Binding Protein Folding Chaperone Metal Ion Binding
	Biological Process	Intracellular Protein Transport Endocytosis Protein Transport Vesicle-mediated Transport Synaptic Vesicle Endocytosis Clathrin-dependent Endocytosis Postsynaptic Neurotransmitter Receptor Internalization	Microtubule Cytoskeleton Organization Inner Cell Mass Cell Proliferation Trophectodermal Cell Proliferation DNA Replication MRNA Processing Protein Folding Signal Transduction RNA Splicing Positive Regulation Of Gene Expression Spinal Cord Development Cell Differentiation Cajal Body Organization Regulation Of Myelination Positive Regulation Of RNA Splicing DNA Endoreduplication Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of Cell Cycle Positive Regulation Of Growth Axon Development Cellular Response To Epidermal Growth Factor Stimulus Apoptotic Process Involved In Development Pre-mRNA Catabolic Process Negative Regulation Of Motor Neuron Apoptotic Process
Pathways		Nef Mediated CD4 Down-regulation Retrograde neurotrophin signalling Retrograde neurotrophin signalling Nef Mediated CD8 Down-regulation MHC class II antigen presentation EPH-ephrin mediated repulsion of cells Recycling pathway of L1 Recycling pathway of L1 WNT5A-dependent internalization of FZD4 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Neutrophil degranulation Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis VLDLR internalisation and degradation LDL clearance Potential therapeutics for SARS
Drugs
Diseases
GWAS		Adult asthma ( 27611488) Alzheimer's disease ( 30636644) Alzheimer's disease (late onset) ( 24162737) Asthma ( 31959851) Chronic bronchitis and chronic obstructive pulmonary disease ( 25241909) Nicotine withdrawal ( 29532581) Nicotine withdrawal symptom count ( 29532581)	Aspartate aminotransferase levels ( 33547301) Cholesterol ( 31902109) Coronary artery disease ( 29212778 29263402) Delirium ( 29631748) Fasting triglyceride levels ( 32603185) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) High density lipoprotein cholesterol levels ( 29403010) Low density lipoprotein cholesterol levels ( 29403010) Metabolic syndrome ( 30382898 31589552) Myocardial infarction ( 33532862) Postprandial triglyceride levels ( 32603185) Postprandial triglyceride response to high fat diet meal ( 26256467) Total cholesterol levels ( 29615537) Triglyceride levels ( 29615537) Triglyceride levels in HIV infection ( 33109212)
Interacting Genes		18 interacting genes: AMPH ANXA1 AP1S1 AP2B1 APP BIN1 DNAJC6 DNM1 EPN1 EPS15 HTT NLGN3 NUMB SHC1 SLC2A8 SMAD1 SNAP91 UBC	7 interacting genes: CDK5RAP2 EEF1A1 EGFR MPP3 OGT SNUPN SUMO4
Entrez ID		161	8882
HPRD ID		06256	04877
Ensembl ID		ENSG00000183020	ENSG00000109917
Uniprot IDs		O94973	O75312
PDB IDs
Enriched GO Terms of Interacting Partners?		Clathrin-coated Pit Endocytosis Import Into Cell Vesicle-mediated Transport Clathrin Binding Receptor-mediated Endocytosis Phospholipid Binding Clathrin Coat Assembly Extrinsic Component Of Presynaptic Endocytic Zone Membrane Cytoplasmic Vesicle Vesicle-mediated Transport In Synapse Synaptic Vesicle Endocytosis Presynaptic Endocytosis Synaptic Vesicle Regulation Of Endocytosis Early Endosome Clathrin-coated Vesicle Regulation Of Vesicle-mediated Transport Establishment Of Localization In Cell Clathrin-dependent Endocytosis Synapse Regulation Of Receptor-mediated Endocytosis Cellular Response To Growth Factor Stimulus Endosome Postsynaptic Neurotransmitter Receptor Internalization Response To Growth Factor Plasma Membrane Postsynaptic Endocytic Zone Cytoplasmic Vesicle Membrane Intracellular Transport Clathrin Heavy Chain Binding Vesicle Regulation Of Transport AP-2 Adaptor Complex Organelle Organization Presynapse Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Clathrin Adaptor Activity Regulation Of Multicellular Organismal Development Regulation Of Clathrin-dependent Endocytosis Positive Regulation Of Cellular Component Organization Cellular Localization Negative Regulation Of Blood Circulation Regulation Of Developmental Process Insulin Receptor Binding Membrane Regulation Of Cellular Component Organization Positive Regulation Of Transport Membrane Coat Chemical Synaptic Transmission	Kinase Binding Clathrin-coated Endocytic Vesicle Membrane Response To Epidermal Growth Factor Regulation Of Protein Catabolic Process Cellular Response To Epidermal Growth Factor Stimulus Multivesicular Body, Internal Vesicle Lumen Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly
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