PCDH18

Description		protocadherin 18
Image
GO Annotations	Cellular Component	Plasma Membrane Membrane
	Molecular Function	Calcium Ion Binding Protein Binding Cell Adhesion Molecule Binding
	Biological Process	Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Brain Development
Pathways
Drugs
Diseases
GWAS		Adult body size ( 32376654) Adverse response to radiation therapy ( 23719583) Body size at age 10 ( 32376654) Copper levels ( 26025379) Epstein-Barr virus copy number in lymphoblastoid cell lines ( 28654678) Essential hypertension (time to event) ( 32589924) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (beta blocking agents) ( 31015401) Obesity-related traits ( 23251661) Obsessive-compulsive disorder or autism spectrum disorder ( 28641744) P wave terminal force ( 28794112) Refractive error ( 32231278) Retinopathy in non-diabetics ( 23393555) Temperament ( 22832960) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535) Urate levels (BMI interaction) ( 25811787)
Interacting Genes		2 interacting genes: DAB1 UBQLN1
Entrez ID		54510
HPRD ID		12205
Ensembl ID		ENSG00000189184
Uniprot IDs		Q9HCL0
PDB IDs		6VFR
Enriched GO Terms of Interacting Partners?		Lateral Motor Column Neuron Migration Cerebellum Structural Organization Cell-cell Adhesion Involved In Neuronal-glial Interactions Involved In Cerebral Cortex Radial Glia Guided Migration Spinal Cord Motor Neuron Migration Radial Glia Guided Migration Of Purkinje Cell Negative Regulation Of Store-operated Calcium Channel Activity Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Radial Glia-guided Pyramidal Neuron Migration Negative Regulation Of Astrocyte Differentiation Cell Migration In Hindbrain Golgi Localization Perinuclear Region Of Cytoplasm Ventral Spinal Cord Development Reelin-mediated Signaling Pathway Motor Neuron Migration Aggrephagy Regulation Of Toll-like Receptor 3 Signaling Pathway Layer Formation In Cerebral Cortex Anatomical Structure Arrangement Positive Regulation Of ERAD Pathway Cerebral Cortex Radially Oriented Cell Migration Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Glial Cell Differentiation Regulation Of ERAD Pathway Negative Regulation Of Transporter Activity Regulation Of Synapse Maturation Negative Regulation Of Receptor Signaling Pathway Via STAT Regulation Of Astrocyte Differentiation Cerebral Cortex Cell Migration Astrocyte Differentiation Adult Walking Behavior Aggresome Walking Behavior Polyubiquitin Modification-dependent Protein Binding Negative Regulation Of Calcium Ion Transmembrane Transport Positive Regulation Of Response To Endoplasmic Reticulum Stress Negative Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Negative Regulation Of Gliogenesis Telencephalon Cell Migration Dendrite Development Forebrain Cell Migration Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Axonogenesis Negative Regulation Of Calcium Ion Transport Autophagosome Maturation Negative Regulation Of Signal Transduction Proteasome Complex Negative Regulation Of Cell Communication Cell Surface Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Signaling
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