UROD and PHKA2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		UROD	PHKA2
Description		uroporphyrinogen decarboxylase	phosphorylase kinase regulatory subunit alpha 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol	Cytoplasm Cytosol Plasma Membrane Phosphorylase Kinase Complex Membrane
	Molecular Function	Uroporphyrinogen Decarboxylase Activity Protein Binding Lyase Activity Carboxy-lyase Activity	Phosphorylase Kinase Activity Protein Binding Calmodulin Binding
	Biological Process	Porphyrin-containing Compound Metabolic Process Porphyrin-containing Compound Biosynthetic Process Protoporphyrinogen IX Biosynthetic Process Heme Biosynthetic Process Heme A Biosynthetic Process Heme B Biosynthetic Process Porphyrin-containing Compound Catabolic Process Heme Metabolic Process Heme O Biosynthetic Process	Carbohydrate Metabolic Process Glycogen Metabolic Process Generation Of Precursor Metabolites And Energy Protein Modification Process
Pathways		Heme biosynthesis	Glycogen breakdown (glycogenolysis)
Drugs		Coproporphyrin I Coproporphyrinogen III
Diseases		Hepatic porphyria, including: Porphyria Cutanea Tarda (PCT); VHepatoerythropoietic porphyria; Acute Intermittent Porphyria (AIP); Variegate porphyria (VP); ALA-dehydratase deficiency porphyria (ALADP); Hereditary Coproporphyria (HCP)	Glycogen storage diseases (GSD), including: von Gierke disease (GSD type Ia); Pompe disease (GSD type II); Cori disease, Forbe disease (GSD type III); Andersen disease (GSD type IV); McArdle disease (GSD type V); Hers disease (GSD type VI); Tarui disease (GSD type VII); Phosphorylase kinase deficiency (GSD type IX); Fanconi-Bickel syndrome (GSD type XI); Glycogen synthase deficiency (GSD type 0)
GWAS
Interacting Genes		11 interacting genes: CHD3 EGFR FAF1 FBXO7 HMGXB4 LRATD2 PHKA2 PILRA RUNX1 TSSK3 VIM	4 interacting genes: PHKB RAF1 SMAD9 UROD
Entrez ID		7389	5256
HPRD ID		01441	02380
Ensembl ID		ENSG00000126088	ENSG00000044446
Uniprot IDs		A0A494C0Q8 P06132	P46019
PDB IDs		1JPH 1JPI 1JPK 1R3Q 1R3R 1R3S 1R3T 1R3V 1R3W 1R3Y 1URO 2Q6Z 2Q71 3GVQ 3GVR 3GVV 3GVW 3GW0 3GW3
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Collagen Biosynthetic Process Regulation Of Collagen Metabolic Process Regulation Of Collagen Biosynthetic Process Positive Regulation Of DNA Replication Multivesicular Body, Internal Vesicle Lumen Chondroitin Sulfate Proteoglycan Binding Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Negative Regulation Of Lymphocyte Differentiation	Heteromeric SMAD Protein Complex SMAD Protein Complex Phosphorylase Kinase Complex Insulin Secretion Involved In Cellular Response To Glucose Stimulus Adenylate Cyclase Activator Activity ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway Death-inducing Signaling Complex Assembly Heme O Biosynthetic Process Porphyrin-containing Compound Catabolic Process Uroporphyrinogen Decarboxylase Activity Heme A Biosynthetic Process Protoporphyrinogen IX Biosynthetic Process Heme B Biosynthetic Process Protoporphyrinogen IX Metabolic Process Type II Interferon-mediated Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway SMAD Protein Signal Transduction Intracellular Chemical Homeostasis I-SMAD Binding Response To Muscle Stretch Type B Pancreatic Cell Proliferation Schwann Cell Development ERBB2 Signaling Pathway MAP Kinase Kinase Kinase Activity Positive Regulation Of Peptidyl-serine Phosphorylation Face Development Pseudopodium Tetrapyrrole Biosynthetic Process Porphyrin-containing Compound Biosynthetic Process Heme Biosynthetic Process Carboxy-lyase Activity Cellular Response To BMP Stimulus Neurotrophin Signaling Pathway Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Thyroid Gland Development Cellular Homeostasis Enzyme-linked Receptor Protein Signaling Pathway Insulin-like Growth Factor Receptor Signaling Pathway Heme Metabolic Process
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?