UROD

Gene Name		uroporphyrinogen decarboxylase
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Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Uroporphyrinogen Decarboxylase Activity
	Biological Process	Porphyrin-containing Compound Metabolic Process Protoporphyrinogen IX Biosynthetic Process Heme Biosynthetic Process Small Molecule Metabolic Process
Pathways		Heme biosynthesis Metabolism of porphyrins
Drugs		Coproporphyrin I Coproporphyrin Iii
Diseases
GWAS
Protein-protein Interactions		6 interactors: CHD3 EGFR FAF1 FAM84B HMGXB4 VIM
Entrez ID		7389
HPRD ID		01441
Ensembl ID		ENSG00000126088
Uniprot IDs		P06132
PDB IDs		1JPH 1JPI 1JPK 1R3Q 1R3R 1R3S 1R3T 1R3V 1R3W 1R3Y 1URO 2Q6Z 2Q71 3GVQ 3GVR 3GVV 3GVW 3GW0 3GW3
Enriched GO Terms of Interacting Partners?		Astrocyte Development Astrocyte Differentiation Glial Cell Development Alkanesulfonate Metabolic Process Activation Of Phospholipase A2 Activity By Calcium-mediated Signaling Astrocyte Activation Regulation Of Protein Import Into Nucleus Glial Cell Differentiation Regulation Of Protein Localization To Nucleus Regulation Of Nucleocytoplasmic Transport Activation Of Phospholipase A2 Activity Negative Regulation Of Signal Transduction Positive Regulation Of Phospholipase A2 Activity Gliogenesis Negative Regulation Of Signaling Response To Cobalamin Response To UV-A Regulation Of Intracellular Protein Transport Cytoplasmic Sequestering Of NF-kappaB Response To Hydroxyisoflavone Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G1/S Transition Of Mitotic Cell Cycle Bergmann Glial Cell Differentiation Positive Regulation Of Superoxide Anion Generation Positive Regulation Of Catenin Import Into Nucleus Regulation Of Phospholipase A2 Activity Regulation Of Protein Catabolic Process Regulation Of Superoxide Anion Generation Magnesium Ion Homeostasis Regulation Of Metabolic Process Regulation Of Intracellular Transport Intermediate Filament Organization Negative Regulation Of NF-kappaB Import Into Nucleus Cellular Response To Estradiol Stimulus Lens Fiber Cell Development Protein Insertion Into Membrane Cytoplasmic Sequestering Of Transcription Factor Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Synaptic Transmission, Glutamatergic Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Catenin Import Into Nucleus Cellular Response To Epidermal Growth Factor Stimulus Cytoplasmic Sequestering Of Protein
Tagcloud ?		affinities arg37 arg41 arg803 asp863 attempts backbone candidates catalytic cmu computational decarboxylase edu egfr evolving head her2 http modulate neck radiotherapy residues taiwan tcm thr854 thr862 traditional tw uroporphyrinogen