UROD and TSSK3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		UROD	TSSK3
Description		uroporphyrinogen decarboxylase	testis specific serine kinase 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol	Cilium Motile Cilium Sperm Flagellum Cell Projection
	Molecular Function	Uroporphyrinogen Decarboxylase Activity Protein Binding Lyase Activity Carboxy-lyase Activity	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Manganese Ion Binding Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Porphyrin-containing Compound Metabolic Process Porphyrin-containing Compound Biosynthetic Process Protoporphyrinogen IX Biosynthetic Process Heme Biosynthetic Process Heme A Biosynthetic Process Heme B Biosynthetic Process Porphyrin-containing Compound Catabolic Process Heme Metabolic Process Heme O Biosynthetic Process	Protein Phosphorylation Spermatogenesis Spermatid Development Cell Differentiation
Pathways		Heme biosynthesis
Drugs		Coproporphyrin I Coproporphyrinogen III
Diseases		Hepatic porphyria, including: Porphyria Cutanea Tarda (PCT); VHepatoerythropoietic porphyria; Acute Intermittent Porphyria (AIP); Variegate porphyria (VP); ALA-dehydratase deficiency porphyria (ALADP); Hereditary Coproporphyria (HCP)
GWAS			Pre-treatment viral load in HIV-1 infection ( 31219150)
Interacting Genes		11 interacting genes: CHD3 EGFR FAF1 FBXO7 HMGXB4 LRATD2 PHKA2 PILRA RUNX1 TSSK3 VIM	67 interacting genes: ADAMTSL4 ARID5A ATP23 CATSPERT CENPN COXFA4L3 DDIT4L DRG2 ECSIT EFHC2 EYA2 FUT9 GOLGA2 GP2 IKZF3 INCA1 KRT75 KRTAP13-2 KRTAP13-3 LBX1 LHX3 LMO2 LNX1 LZTS2 MBD3L1 MEI4 MRPL28 MSX2 MYOG MYOZ3 NFKBID NME4 OIP5 PBX4 PJA1 PLEKHG4 PPP1R16A PRDM6 RBBP4 RBCK1 REL RIN3 RUSC1 SHISA6 SLAIN1 SMAD4 SPMIP6 STAT5B SYNGAP1 TCF4 TCP10L TEPSIN TGM7 TLE5 TRIM35 TRIM50 TRIM54 TRIM9 TRIP6 UROD USP54 VGLL1 VPS52 YJU2B YPEL3 ZBTB25 ZMYND12
Entrez ID		7389	81629
HPRD ID		01441	09635
Ensembl ID		ENSG00000126088	ENSG00000162526
Uniprot IDs		A0A494C0Q8 P06132	Q96PN8
PDB IDs		1JPH 1JPI 1JPK 1R3Q 1R3R 1R3S 1R3T 1R3V 1R3W 1R3Y 1URO 2Q6Z 2Q71 3GVQ 3GVR 3GVV 3GVW 3GW0 3GW3
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Collagen Biosynthetic Process Regulation Of Collagen Metabolic Process Regulation Of Collagen Biosynthetic Process Positive Regulation Of DNA Replication Multivesicular Body, Internal Vesicle Lumen Chondroitin Sulfate Proteoglycan Binding Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Negative Regulation Of Lymphocyte Differentiation	Protein Binding Transcription Regulator Complex
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