UROD and HMGXB4

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		UROD	HMGXB4
Gene Name		uroporphyrinogen decarboxylase	HMG box domain containing 4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol	NURF Complex
	Molecular Function	Uroporphyrinogen Decarboxylase Activity	DNA Binding Chromatin Binding
	Biological Process	Porphyrin-containing Compound Metabolic Process Protoporphyrinogen IX Biosynthetic Process Heme Biosynthetic Process Small Molecule Metabolic Process	Chromatin Remodeling Regulation Of Transcription, DNA-templated Endosome To Lysosome Transport Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway
Pathways		Heme biosynthesis Metabolism of porphyrins
Drugs		Coproporphyrin I Coproporphyrin Iii
Diseases
GWAS
Protein-Protein Interactions		6 interactors: CHD3 EGFR FAF1 FAM84B HMGXB4 VIM	7 interactors: HABP4 HIST3H3 JMJD6 NR1H2 TNNT1 TSC22D1 UROD
Entrez ID		7389	10042
HPRD ID		01441	05267
Ensembl ID		ENSG00000126088	ENSG00000100281
Uniprot IDs		P06132	Q7Z641 Q9UGU5
PDB IDs		1JPH 1JPI 1JPK 1R3Q 1R3R 1R3S 1R3T 1R3V 1R3W 1R3Y 1URO 2Q6Z 2Q71 3GVQ 3GVR 3GVV 3GVW 3GW0 3GW3
Enriched GO Terms of Interacting Partners?		Astrocyte Development Astrocyte Differentiation Glial Cell Development Alkanesulfonate Metabolic Process Activation Of Phospholipase A2 Activity By Calcium-mediated Signaling Astrocyte Activation Regulation Of Protein Import Into Nucleus Glial Cell Differentiation Regulation Of Protein Localization To Nucleus Regulation Of Nucleocytoplasmic Transport Activation Of Phospholipase A2 Activity Negative Regulation Of Signal Transduction Positive Regulation Of Phospholipase A2 Activity Gliogenesis Negative Regulation Of Signaling Response To Cobalamin Response To UV-A Regulation Of Intracellular Protein Transport Cytoplasmic Sequestering Of NF-kappaB Response To Hydroxyisoflavone Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G1/S Transition Of Mitotic Cell Cycle Bergmann Glial Cell Differentiation Positive Regulation Of Superoxide Anion Generation Positive Regulation Of Catenin Import Into Nucleus Regulation Of Phospholipase A2 Activity Regulation Of Protein Catabolic Process Regulation Of Superoxide Anion Generation Magnesium Ion Homeostasis Regulation Of Metabolic Process Regulation Of Intracellular Transport Intermediate Filament Organization Negative Regulation Of NF-kappaB Import Into Nucleus Cellular Response To Estradiol Stimulus Lens Fiber Cell Development Protein Insertion Into Membrane Cytoplasmic Sequestering Of Transcription Factor Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Synaptic Transmission, Glutamatergic Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Catenin Import Into Nucleus Cellular Response To Epidermal Growth Factor Stimulus Cytoplasmic Sequestering Of Protein	Positive Regulation Of Secretion Of Lysosomal Enzymes Positive Regulation Of Pancreatic Juice Secretion Positive Regulation Of High-density Lipoprotein Particle Assembly Histone H3-R2 Demethylation Histone H4-R3 Demethylation Peptidyl-lysine Hydroxylation To 5-hydroxy-L-lysine Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of High-density Lipoprotein Particle Assembly Nitrogen Compound Metabolic Process Negative Regulation Of Pinocytosis Negative Regulation Of Interferon-gamma-mediated Signaling Pathway Slow-twitch Skeletal Muscle Fiber Contraction Negative Regulation Of Cholesterol Storage Recognition Of Apoptotic Cell Transcription, DNA-templated Positive Regulation Of Digestive System Process Protoporphyrinogen IX Biosynthetic Process RNA Biosynthetic Process Protoporphyrinogen IX Metabolic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of Fatty Acid Biosynthetic Process Regulation Of Cholesterol Homeostasis Positive Regulation Of Lipoprotein Lipase Activity Positive Regulation Of Triglyceride Biosynthetic Process Positive Regulation Of Cholesterol Efflux Negative Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Cholesterol Transport Phagocytosis, Recognition Biosynthetic Process Homeostatic Process Negative Regulation Of Lipid Storage Regulation Of Triglyceride Biosynthetic Process Regulation Of Cholesterol Efflux Regulation Of Interferon-gamma-mediated Signaling Pathway Negative Regulation Of Muscle Contraction Regulation Of Response To Interferon-gamma Negative Regulation Of Lipid Transport Retinoic Acid Receptor Signaling Pathway RNA Metabolic Process Skeletal Muscle Contraction Heme Biosynthetic Process Protein Hydroxylation Macrophage Activation Positive Regulation Of Lipid Storage Actin-myosin Filament Sliding Positive Regulation Of Fatty Acid Metabolic Process Apoptotic Cell Clearance Muscle Filament Sliding
Tagcloud ?		affinities arg37 arg41 arg803 asp863 attempts backbone candidates catalytic cmu computational decarboxylase edu egfr evolving head her2 http modulate neck radiotherapy residues taiwan tcm thr854 thr862 traditional tw uroporphyrinogen
Tagcloud (Difference) ?		affinities arg37 arg41 arg803 asp863 attempts backbone candidates catalytic cmu computational decarboxylase edu egfr evolving head her2 http modulate neck radiotherapy residues taiwan tcm thr854 thr862 traditional tw uroporphyrinogen
Tagcloud (Intersection) ?