CYBB and NCF2

Number of citations of the paper that reports this interaction (PMID 11893732)
70

Data Source:
HPRD (in vitro, in vivo)

		CYBB	NCF2
Gene Name		cytochrome b-245, beta polypeptide	neutrophil cytosolic factor 2
Image
Gene Ontology Annotations	Cellular Component	Mitochondrion Rough Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Dendrite Phagocytic Vesicle Membrane NADPH Oxidase Complex Neuronal Cell Body	Acrosomal Vesicle Nucleolus Cytoplasm Cytosol Phagolysosome NADPH Oxidase Complex
	Molecular Function	Voltage-gated Ion Channel Activity Protein Binding Electron Carrier Activity Superoxide-generating NADPH Oxidase Activity Heme Binding Metal Ion Binding Protein Heterodimerization Activity Flavin Adenine Dinucleotide Binding	Protein Binding Protein C-terminus Binding Electron Carrier Activity Rac GTPase Binding
	Biological Process	Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Superoxide Metabolic Process Ion Transport Inflammatory Response Response To Nutrient Regulation Of Ion Transmembrane Transport Response To Drug Superoxide Anion Generation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Innate Immune Response Respiratory Burst Vascular Endothelial Growth Factor Receptor Signaling Pathway Hydrogen Peroxide Biosynthetic Process Interaction With Host Oxidation-reduction Process Phagosome Maturation	Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Superoxide Metabolic Process Cellular Defense Response Aging Response To Glucose Response To Activity Response To Lipopolysaccharide Response To Progesterone Cellular Response To Hormone Stimulus Response To Laminar Fluid Shear Stress Response To Drug Superoxide Anion Generation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Positive Regulation Of Neuron Apoptotic Process Innate Immune Response Respiratory Burst Positive Regulation Of Blood Pressure Vascular Endothelial Growth Factor Receptor Signaling Pathway Interaction With Host Response To Hyperoxia Phagosome Maturation
Pathways		Signaling by VEGF Phagosomal maturation (early endosomal stage) Latent infection of Homo sapiens with Mycobacterium tuberculosis Class I MHC mediated antigen processing & presentation Antigen processing-Cross presentation VEGFA-VEGFR2 Pathway Cross-presentation of particulate exogenous antigens (phagosomes) Adaptive Immune System	Signaling by VEGF Phagosomal maturation (early endosomal stage) Latent infection of Homo sapiens with Mycobacterium tuberculosis Class I MHC mediated antigen processing & presentation Antigen processing-Cross presentation VEGFA-VEGFR2 Pathway Cross-presentation of particulate exogenous antigens (phagosomes) Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		6 interactors: ACTG1 CYBA IQGAP1 NCF2 NCF4 RAC1	14 interactors: ACTB CDC42 CYBA CYBB GOLGA2 KIFAP3 NCF4 PRDX6 PRKDC RAC1 RAC2 S100A8 S100A9 SYTL1
Entrez ID		1536	4688
HPRD ID		02382	01991
Ensembl ID		ENSG00000165168	ENSG00000116701
Uniprot IDs		F5GWD2 P04839	P19878
PDB IDs		3A1F	1E96 1HH8 1K4U 1OEY 1WM5 2DMO
Enriched GO Terms of Interacting Partners?		Vascular Endothelial Growth Factor Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Phagosome Maturation Interaction With Host Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Immune Response Respiratory Burst Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Cell Surface Receptor Signaling Pathway Superoxide Anion Generation Antigen Processing And Presentation Of Peptide Antigen Innate Immune Response Antigen Processing And Presentation Positive Regulation Of Blood Pressure Immune System Process Superoxide Metabolic Process Signal Transduction Defense Response Signaling Cell Communication Organelle Organization Ephrin Receptor Signaling Pathway Negative Regulation Of Glomerular Filtration By Angiotensin Smooth Muscle Hypertrophy Regulation Of Body Fluid Levels Reactive Oxygen Species Metabolic Process Neuron Projection Morphogenesis Response To Glucose Response To External Stimulus Cellular Response To Stimulus Embryonic Olfactory Bulb Interneuron Precursor Migration Negative Regulation Of Interleukin-23 Production Cellular Response To Organic Substance Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Engulfment Of Apoptotic Cell Regulation Of Renal Output By Angiotensin Neuron Projection Development Regulation Of Blood Pressure Cell Projection Morphogenesis Tissue Homeostasis Cell Part Morphogenesis Response To Carbohydrate Mast Cell Chemotaxis Platelet Activation Epithelial Cell Development Cell-cell Junction Organization	Vascular Endothelial Growth Factor Receptor Signaling Pathway Innate Immune Response Immune Response Immune System Process Response To Stress Defense Response Single Organismal Cell-cell Adhesion Neutrophil Aggregation Regulation Of Body Fluid Levels Chemotaxis Wound Healing Homotypic Cell-cell Adhesion Hydrogen Peroxide Metabolic Process Organelle Organization Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Wounding Sequestering Of Zinc Ion Cell Adhesion Response To External Stimulus Phagosome Maturation Blood Coagulation Inflammatory Response Hemostasis Homeostatic Process Enzyme Linked Receptor Protein Signaling Pathway Leukocyte Migration Antigen Processing And Presentation Of Peptide Antigen Movement Of Cell Or Subcellular Component Hydrogen Peroxide Biosynthetic Process Chemokine Production Regulation Of Hydrogen Peroxide Metabolic Process Sequestering Of Metal Ion Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Leukocyte Aggregation Antigen Processing And Presentation Regulation Of Respiratory Burst Respiratory Burst Ephrin Receptor Signaling Pathway Chronic Inflammatory Response Positive Regulation Of Lamellipodium Assembly Interaction With Host Leukocyte Cell-cell Adhesion Leukocyte Chemotaxis Cellular Zinc Ion Homeostasis Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Reactive Oxygen Species Metabolic Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Regulation Of Cell Projection Assembly
Tagcloud ?		allelic candidiasis definition designation errors ifngr1 ifngr2 il12b il12rb1 immunological impair inborn intramacrophagic irf8 isg15 mendelian msmd mycobacteria nemo overt parasites penetrance perhaps physiologically predisposition recapitulate salmonellosis virulent weakly	anion besides biopsies chl copy cyba cybb deleterious deletions downregulation exert hodgkin hybridisation lines lymphoma nadph ncf1 ncf4 oxidase phagocytic profiling progenitors proved quantify recurrent reed sternberg subsets superoxide
Tagcloud (Difference) ?		allelic candidiasis definition designation errors ifngr1 ifngr2 il12b il12rb1 immunological impair inborn intramacrophagic irf8 isg15 mendelian msmd mycobacteria nemo overt parasites penetrance perhaps physiologically predisposition recapitulate salmonellosis virulent weakly	anion besides biopsies chl copy cyba deleterious deletions downregulation exert hodgkin hybridisation lines lymphoma nadph ncf1 ncf4 oxidase phagocytic profiling progenitors proved quantify recurrent reed sternberg subsets superoxide
Tagcloud (Intersection) ?		cybb