CYBB and CYBC1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CYBB	CYBC1
Description		cytochrome b-245 beta chain	cytochrome b-245 chaperone 1
Image
GO Annotations	Cellular Component	Nuclear Envelope Cytoplasm Endoplasmic Reticulum Membrane Plasma Membrane Membrane Dendrite Phagocytic Vesicle Membrane Monoatomic Ion Channel Complex Specific Granule Membrane NADPH Oxidase Complex Neuronal Cell Body Phagocytic Vesicle Tertiary Granule Membrane Perinuclear Endoplasmic Reticulum	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Protein Binding Electron Transfer Activity NAD(P)H Oxidase H2O2-forming Activity Superoxide-generating NAD(P)H Oxidase Activity Oxidoreductase Activity Heme Binding Voltage-gated Proton Channel Activity Metal Ion Binding Protein Heterodimerization Activity Flavin Adenine Dinucleotide Binding Oxidoreductase Activity, Acting On NAD(P)H, Oxygen As Acceptor NADPH Binding FAD Binding Superoxide-generating NADPH Oxidase Activity	Protein Binding
	Biological Process	Superoxide Metabolic Process Monoatomic Ion Transport Defense Response Inflammatory Response Response To Nutrient Response To Xenobiotic Stimulus Positive Regulation Of Tumor Necrosis Factor Production Monoatomic Ion Transmembrane Transport Superoxide Anion Generation Innate Immune Response Response To Ethanol Respiratory Burst Positive Regulation Of Angiogenesis Hydrogen Peroxide Biosynthetic Process Cellular Response To Cadmium Ion Cellular Response To Ethanol Cellular Response To Hypoxia Hypoxia-inducible Factor-1alpha Signaling Pathway Response To Aldosterone Cellular Response To L-glutamine Response To Angiotensin	Immune System Process Innate Immune Response Respiratory Burst After Phagocytosis
Pathways		ROS and RNS production in phagocytes Cross-presentation of particulate exogenous antigens (phagosomes) Detoxification of Reactive Oxygen Species VEGFA-VEGFR2 Pathway RHO GTPases Activate NADPH Oxidases Neutrophil degranulation RAC1 GTPase cycle RAC2 GTPase cycle RAC3 GTPase cycle
Drugs		Dextromethorphan
Diseases		Chronic granulomatous disease, including the following four diseases: X-linked CGD (gp91 phox CGD); p22phox deficiency (p22phox CGD); p47phox deficiency (p47phox CGD); p67phox deficiency (p67phox CGD)
GWAS
Interacting Genes		7 interacting genes: ACTG1 CYBA CYBC1 IQGAP1 NCF2 NCF4 RAC1	65 interacting genes: ADIPOQ AGTRAP AHNAK2 AIG1 APCDD1L APOA2 APOL2 AQP10 AQP6 AQP8 ARLN BET1 C14orf180 CD53 CISD2 CLDN7 CLN6 COQ9 CPLX4 CREB3 CREB3L1 CYBB ERGIC3 ETS1 FAM209A GJA8 GPR151 GPR152 GPX8 HSD17B11 HSD17B13 INSIG2 JAGN1 KASH5 KIR2DL3 LAT LMNA LXN MFF MGST3 MTIF3 NINJ2 NOX3 NRM P2RX1 PDZK1IP1 PEX12 PLIN3 PLP1 PLP2 SCD SHISA4 SLC35H1 SLC71A2 SPN SSMEM1 STX2 THBD TM4SF19 TMEM128 TMEM80 TMPRSS2 TMX2 TRAM1L1 TSPAN12
Entrez ID		1536	79415
HPRD ID		02382	14630
Ensembl ID		ENSG00000165168	ENSG00000178927
Uniprot IDs		A0A0S2Z3S6 P04839	Q9BQA9
PDB IDs		3A1F 7U8G 8GZ3 8KEI 8WEJ 8X2L	8KEI
Enriched GO Terms of Interacting Partners?		Respiratory Burst NADPH Oxidase Complex Superoxide Anion Generation Superoxide Metabolic Process Reactive Oxygen Species Metabolic Process Phagolysosome Actin Filament Superoxide-generating NADPH Oxidase Activator Activity Superoxide-generating NAD(P)H Oxidase Activity Focal Adhesion Regulation Of Synaptic Vesicle Endocytosis Regulation Of Synaptic Vesicle Recycling Basal Body Patch Regulation Of Focal Adhesion Assembly Regulation Of Endocytosis Smooth Muscle Hypertrophy Negative Regulation Of Glomerular Filtration By Angiotensin Electron Transfer Activity Regulation Of Cell-substrate Junction Organization Protein Kinase Binding Regulation Of Stress Fiber Assembly Endocytosis Phagocytosis Positive Regulation Of Ovarian Follicle Development Negative Regulation Of Interleukin-23 Production Cytoplasmic Ribonucleoprotein Granule Regulation Of ERK5 Cascade Angiotensin-activated Signaling Pathway Involved In Heart Process Embryonic Olfactory Bulb Interneuron Precursor Migration Secretory Granule Membrane Cerebral Cortex GABAergic Interneuron Development Regulation Of Renal Output By Angiotensin Rho GDP-dissociation Inhibitor Binding Regulation Of Cell Adhesion Involved In Heart Morphogenesis Mitotic Actomyosin Contractile Ring Assembly Actin Filament Organization Regulation Of Cell-matrix Adhesion Regulation Of Transepithelial Transport Regulation Of Vesicle-mediated Transport Cellular Response To L-glutamine Regulation Of Reactive Oxygen Species Metabolic Process Response To External Biotic Stimulus Mitotic Spindle Astral Microtubule Actomyosin Contractile Ring Assembly Actin Filament Organization Respiratory Burst After Phagocytosis Dense Body Positive Regulation Of Mucus Secretion Defense Response Import Into Cell Regulation Of Ovarian Follicle Development Erythrocyte Enucleation	Membrane Protein Binding Endoplasmic Reticulum Membrane Endoplasmic Reticulum Water Channel Activity Channel Activity Negative Regulation Of Cholesterol Import Steroid Dehydrogenase Activity Oxidoreductase Activity, Acting On NAD(P)H, Oxygen As Acceptor Regulation Of Cholesterol Import One-carbon Compound Transport Water Transport Superoxide-generating NADPH Oxidase Activity Identical Protein Binding Fluid Transport Lipid Droplet Ammonium Channel Activity Urea Transmembrane Transport
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?