CYBB and CYBA

Number of citations of the paper that reports this interaction (PubMedID 7938008)
29

Data Source:
HPRD (in vitro, in vivo)

		CYBB	CYBA
Description		cytochrome b-245 beta chain	cytochrome b-245 alpha chain
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GO Annotations	Cellular Component	Nuclear Envelope Cytoplasm Endoplasmic Reticulum Membrane Plasma Membrane Membrane Dendrite Phagocytic Vesicle Membrane Monoatomic Ion Channel Complex Specific Granule Membrane NADPH Oxidase Complex Neuronal Cell Body Phagocytic Vesicle Tertiary Granule Membrane Perinuclear Endoplasmic Reticulum	Stress Fiber Cytoplasm Endosome Endoplasmic Reticulum Membrane Plasma Membrane Focal Adhesion Membrane Apical Plasma Membrane Secretory Granule Dendrite Phagocytic Vesicle Membrane Specific Granule Membrane NADPH Oxidase Complex Neuronal Cell Body Tertiary Granule Membrane Perinuclear Endoplasmic Reticulum
	Molecular Function	Protein Binding Electron Transfer Activity NAD(P)H Oxidase H2O2-forming Activity Superoxide-generating NAD(P)H Oxidase Activity Oxidoreductase Activity Heme Binding Voltage-gated Proton Channel Activity Metal Ion Binding Protein Heterodimerization Activity Flavin Adenine Dinucleotide Binding Oxidoreductase Activity, Acting On NAD(P)H, Oxygen As Acceptor NADPH Binding FAD Binding Superoxide-generating NADPH Oxidase Activity	Protein Binding Electron Transfer Activity Superoxide-generating NAD(P)H Oxidase Activity Oxidoreductase Activity SH3 Domain Binding Heme Binding Metal Ion Binding Protein Heterodimerization Activity
	Biological Process	Superoxide Metabolic Process Monoatomic Ion Transport Defense Response Inflammatory Response Response To Nutrient Response To Xenobiotic Stimulus Positive Regulation Of Tumor Necrosis Factor Production Monoatomic Ion Transmembrane Transport Superoxide Anion Generation Innate Immune Response Response To Ethanol Respiratory Burst Positive Regulation Of Angiogenesis Hydrogen Peroxide Biosynthetic Process Cellular Response To Cadmium Ion Cellular Response To Ethanol Cellular Response To Hypoxia Hypoxia-inducible Factor-1alpha Signaling Pathway Response To Aldosterone Cellular Response To L-glutamine Response To Angiotensin	Response To Hypoxia Positive Regulation Of Endothelial Cell Proliferation Negative Regulation Of Glomerular Filtration By Angiotensin Superoxide Metabolic Process Inflammatory Response Response To Xenobiotic Stimulus Response To Activity Smooth Muscle Hypertrophy Cytochrome Complex Assembly Positive Regulation Of Cell Growth Response To Nutrient Levels Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Superoxide Anion Generation Positive Regulation Of Toll-like Receptor 2 Signaling Pathway Superoxide Anion Generation Innate Immune Response Respiratory Burst Positive Regulation Of Blood Pressure Positive Regulation Of Smooth Muscle Cell Proliferation Hydrogen Peroxide Biosynthetic Process Positive Regulation Of Phagocytosis Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Establishment Of Localization In Cell Mucus Secretion Positive Regulation Of Mucus Secretion Response To Interleukin-1 Cellular Response To Mechanical Stimulus Cellular Response To Glucose Stimulus Cellular Response To Tumor Necrosis Factor Cellular Response To Gamma Radiation Reactive Oxygen Species Metabolic Process Positive Regulation Of Defense Response To Bacterium Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Response To Aldosterone Cellular Response To Angiotensin Cellular Response To Phorbol 13-acetate 12-myristate Cellular Response To L-glutamine
Pathways		ROS and RNS production in phagocytes Cross-presentation of particulate exogenous antigens (phagosomes) Detoxification of Reactive Oxygen Species VEGFA-VEGFR2 Pathway RHO GTPases Activate NADPH Oxidases Neutrophil degranulation RAC1 GTPase cycle RAC2 GTPase cycle RAC3 GTPase cycle	ROS and RNS production in phagocytes Cross-presentation of particulate exogenous antigens (phagosomes) Detoxification of Reactive Oxygen Species VEGFA-VEGFR2 Pathway RHO GTPases Activate NADPH Oxidases Neutrophil degranulation RAC1 GTPase cycle RAC2 GTPase cycle RAC3 GTPase cycle WNT5:FZD7-mediated leishmania damping
Drugs		Dextromethorphan	Dextromethorphan
Diseases		Chronic granulomatous disease, including the following four diseases: X-linked CGD (gp91 phox CGD); p22phox deficiency (p22phox CGD); p47phox deficiency (p47phox CGD); p67phox deficiency (p67phox CGD)	Chronic granulomatous disease, including the following four diseases: X-linked CGD (gp91 phox CGD); p22phox deficiency (p22phox CGD); p47phox deficiency (p47phox CGD); p67phox deficiency (p67phox CGD)
GWAS			Glycated hemoglobin levels ( 24647736) Hair color ( 26926045)
Interacting Genes		7 interacting genes: ACTG1 CYBA CYBC1 IQGAP1 NCF2 NCF4 RAC1	12 interacting genes: APPBP2 CPT1A CYBB MDFI NCF2 NCF4 NOX1 PSMA3 RAC1 RBPMS RCHY1 UPF2
Entrez ID		1536	1535
HPRD ID		02382	01989
Ensembl ID		ENSG00000165168	ENSG00000051523
Uniprot IDs		A0A0S2Z3S6 P04839	B4DT46 H3BNP7 P13498
PDB IDs		3A1F 7U8G 8GZ3 8KEI 8WEJ 8X2L	1WLP 7U8G 7YXW 8GZ3 8KEI 8WEJ 8X2L
Enriched GO Terms of Interacting Partners?		Respiratory Burst NADPH Oxidase Complex Superoxide Anion Generation Superoxide Metabolic Process Reactive Oxygen Species Metabolic Process Phagolysosome Actin Filament Superoxide-generating NADPH Oxidase Activator Activity Superoxide-generating NAD(P)H Oxidase Activity Focal Adhesion Regulation Of Synaptic Vesicle Endocytosis Regulation Of Synaptic Vesicle Recycling Basal Body Patch Regulation Of Focal Adhesion Assembly Regulation Of Endocytosis Smooth Muscle Hypertrophy Negative Regulation Of Glomerular Filtration By Angiotensin Electron Transfer Activity Regulation Of Cell-substrate Junction Organization Protein Kinase Binding Regulation Of Stress Fiber Assembly Endocytosis Phagocytosis Positive Regulation Of Ovarian Follicle Development Negative Regulation Of Interleukin-23 Production Cytoplasmic Ribonucleoprotein Granule Regulation Of ERK5 Cascade Angiotensin-activated Signaling Pathway Involved In Heart Process Embryonic Olfactory Bulb Interneuron Precursor Migration Secretory Granule Membrane Cerebral Cortex GABAergic Interneuron Development Regulation Of Renal Output By Angiotensin Rho GDP-dissociation Inhibitor Binding Regulation Of Cell Adhesion Involved In Heart Morphogenesis Mitotic Actomyosin Contractile Ring Assembly Actin Filament Organization Regulation Of Cell-matrix Adhesion Regulation Of Transepithelial Transport Regulation Of Vesicle-mediated Transport Cellular Response To L-glutamine Regulation Of Reactive Oxygen Species Metabolic Process Response To External Biotic Stimulus Mitotic Spindle Astral Microtubule Actomyosin Contractile Ring Assembly Actin Filament Organization Respiratory Burst After Phagocytosis Dense Body Positive Regulation Of Mucus Secretion Defense Response Import Into Cell Regulation Of Ovarian Follicle Development Erythrocyte Enucleation	NADPH Oxidase Complex Respiratory Burst Superoxide Anion Generation Superoxide Metabolic Process Reactive Oxygen Species Metabolic Process Superoxide-generating NAD(P)H Oxidase Activity Oxidoreductase Activity, Acting On NAD(P)H, Oxygen As Acceptor Phagolysosome Superoxide-generating NADPH Oxidase Activity Superoxide-generating NADPH Oxidase Activator Activity NAD(P)H Oxidase H2O2-forming Activity Hydrogen Peroxide Metabolic Process Cytoplasm Animal Organ Regeneration Electron Transfer Activity
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