CNTN4 and BARD1

Number of citations of the paper that reports this interaction (PubMedID 22990118)
93

Data Source:
BioGRID (two hybrid)

		CNTN4	BARD1
Description		contactin 4	BRCA1 associated RING domain 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Membrane Axon Synapse Side Of Membrane	Ubiquitin Ligase Complex Nuclear Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Nuclear Speck BRCA1-BARD1 Complex Cytoplasmic Ribonucleoprotein Granule BRCA1-A Complex BRCA1-B Complex BRCA1-C Complex
	Molecular Function	Cell-cell Adhesion Mediator Activity	RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Kinase Binding Protein Homodimerization Activity Metal Ion Binding Protein Heterodimerization Activity Ubiquitin Protein Ligase Activity Ubiquitin-modified Histone Reader Activity Histone H2AK127 Ubiquitin Ligase Activity Histone H2AK129 Ubiquitin Ligase Activity
	Biological Process	Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Neuron Cell-cell Adhesion Nervous System Development Axonogenesis Axon Guidance Axonal Fasciculation Brain Development Neuron Projection Development Negative Regulation Of Neuron Differentiation Regulation Of Synaptic Plasticity Synapse Organization Dendrite Self-avoidance	Tissue Homeostasis DNA Repair Regulation Of DNA Repair Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II DNA Damage Response Protein Ubiquitination Negative Regulation Of MRNA 3'-end Processing Homologous Recombination Regulation Of Phosphorylation Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Mitotic G2/M Transition Checkpoint Positive Regulation Of Protein Catabolic Process Negative Regulation Of Cell Cycle Negative Regulation Of Protein Export From Nucleus Regulation Of Cell Cycle Cellular Response To Ionizing Radiation Protein K6-linked Ubiquitination DNA Strand Resection Involved In Replication Fork Processing Regulation Of DNA Damage Checkpoint
Pathways		Post-translational modification: synthesis of GPI-anchored proteins	HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) UCH proteinases Metalloprotease DUBs Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Resolution of D-loop Structures through Holliday Junction Intermediates Nonhomologous End-Joining (NHEJ) Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Defective DNA double strand break response due to BRCA1 loss of function Defective DNA double strand break response due to BARD1 loss of function Defective homologous recombination repair (HRR) due to BRCA1 loss of function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function Impaired BRCA2 binding to RAD51 Impaired BRCA2 binding to PALB2
Drugs
Diseases
GWAS		Acenocoumarol maintenance dosage ( 19578179) Amyotrophic lateral sclerosis ( 19451621) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Atypical femoral fracture in phosphonate treatment ( 31006051) Autism spectrum disorder or schizophrenia ( 28540026) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 27863252) Bisphosphonate-associated atypical femoral fracture ( 31006051) Blood pressure ( 17903302) Blood pressure (smoking interaction) ( 25189868) Blood protein levels ( 30072576) Body mass index (change over time) in chronic obstructive pulmonary disease ( 28044437) Brain connectivity ( 23471985) Chronotype ( 30696823) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Daytime sleep phenotypes ( 27126917) Diisocyanate-induced asthma ( 25918132) Disease progression in age-related macular degeneration ( 29346644) Femur bone mineral density x serum urate levels interaction ( 34046847) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) HDL cholesterol levels in HIV infection ( 33109212) Heel bone mineral density x serum urate levels interaction ( 34046847) High density lipoprotein cholesterol levels ( 31647587 34074324) High myopia ( 32428537) Intake of total sugars ( 31005972) Intelligence ( 22449649) Metabolite levels ( 23823483) Middle childhood and early adolescence aggressive behavior ( 26087016) Night sleep phenotypes ( 27126917) Pit-and-Fissure caries ( 24556642) Post bronchodilator FEV1/FVC ratio ( 26634245) Response to aripiprazole in schizophrenia ( 29503163) Restless legs syndrome ( 29029846) Schizophrenia ( 29483656 25056061 26198764 30285260 28991256) Sensorimotor dexterity ( 31596458) Serum immune biomarker levels ( 32066700) Serum uric acid levels ( 24379826) Thiopurine-induced pancreatitis in inflammatory bowel disease ( 29923122) Total ventricular volume ( 21116278) White blood cell count (basophil) ( 27863252)	Feeling fed-up ( 29500382) General risk tolerance (MTAG) ( 30643258) Neuroblastoma ( 21124317 22941191) Neuroblastoma (high-risk) ( 19412175) Neuroblastoma (MYCN amplification) ( 28924153) Neurociticism ( 29500382) Sporadic neuroblastoma ( 28545128)
Interacting Genes		3 interacting genes: BARD1 BRCA1 BTG3	131 interacting genes: ACP1 AKIP1 AP1B1 ASH2L ATP1B1 ATP1B3 AXIN2 BCCIP BCL3 BGLT3 BRCA1 BRD7 CAP1 CBX1 CBX3 CBX5 CCDC136 CDK1 CDK2 CEP70 CHD3 CNTN4 COL1A1 COMMD1 CSTF1 DCAF8L2 DCC DDX39B DNAI7 ELP1 ESR1 EWSR1 EXOC5 FAM9B FEZ1 FKBP1A FKBP2 FKBP3 FUCA1 GIT1 GOLGA2 GPRASP2 H2AC20 H2AC4 H2BC3 H3C1 HAP1 HNRNPC HNRNPLL HSF2BP HSPA14 IDI1 IKZF1 ING5 KAT5 KAT7 KBTBD7 KIFC3 KRT40 LARP7 LDOC1 LGALS8 LRIF1 MACROH2A1 MAGED1 MDC1 MRPS22 MSH2 MSH3 MSH6 MT-ND1 MT2A MTUS2 NFKB1 NFKBIA NPC2 PCBP2 PDXK PDZD8 PIAS1 PIAS4 PIN1 POLR2A POLR2H POMZP3 POU2F1 PSMA7 PTN RABEP1 RAD51 RBBP8 RBMY2BP RNF10 RPS20 SELENBP1 SETDB1 SKIC8 SMCHD1 SNRNP200 SNX3 SPAG5 SRSF2 TCERG1 TERF2 TMEM248 TOP1 TP53 TRAF1 TRAPPC11 TRAPPC8 TULP2 UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2E3 UBE2K UBE2N UBE2U UBE2W UBE3A UBR5 UBXN1 WRN XRCC6 ZFP64 ZHX1 ZNF121 ZNF655
Entrez ID		152330	580
HPRD ID		16239	03354
Ensembl ID		ENSG00000144619	ENSG00000138376
Uniprot IDs		Q8IWV2	A0A087WZ19 A0AVN2 C9IYG1 F6MDI0 F6MDI1 F6MDI2 Q99728
PDB IDs			1JM7 2NTE 2R1Z 3C5R 3FA2 6M14 7E8I 7JZV 7LYB 7LYC 8GRQ
Enriched GO Terms of Interacting Partners?		Histone H2AK127 Ubiquitin Ligase Activity Histone H2AK129 Ubiquitin Ligase Activity BRCA1-BARD1 Complex BRCA1-B Complex Nuclear Ubiquitin Ligase Complex BRCA1-C Complex BRCA1-A Complex Ubiquitin-modified Histone Reader Activity DNA Strand Resection Involved In Replication Fork Processing Regulation Of DNA Damage Checkpoint Protein K6-linked Ubiquitination Negative Regulation Of Mitotic Cell Cycle Homologous Recombination Mitotic G2/M Transition Checkpoint Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle G2/M Phase Transition Negative Regulation Of Cell Cycle Cellular Response To Ionizing Radiation Negative Regulation Of MRNA 3'-end Processing Tubulin Binding Ghrelin Receptor Binding Cortisol Secretion Positive Regulation Of Gastric Mucosal Blood Circulation Growth Hormone-releasing Hormone Activity Negative Regulation Of Circadian Sleep/wake Cycle, REM Sleep Positive Regulation Of Small Intestinal Transit Positive Regulation Of Growth Rate Ubiquitin Ligase Complex Regulation Of Mitotic Cell Cycle Negative Regulation Of Protein Transport Regulation Of Cell Cycle G2/M Phase Transition Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Small Intestine Smooth Muscle Contraction Positive Regulation Of Bone Development Positive Regulation Of Growth Hormone Receptor Signaling Pathway Negative Regulation Of Establishment Of Protein Localization Response To Ionizing Radiation Positive Regulation Of Eating Behavior Positive Regulation Of Cortisol Secretion Positive Regulation Of Response To Food Negative Regulation Of Circadian Sleep/wake Cycle, Sleep Regulation Of Circadian Sleep/wake Cycle, REM Sleep Positive Regulation Of Appetite Regulation Of Gastric Motility Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Cellular Response To Indole-3-methanol Neuronal Dense Core Vesicle Lumen Regulation Of Growth Rate Positive Regulation Of Gastro-intestinal System Smooth Muscle Contraction Negative Regulation Of Mitotic Cell Cycle Phase Transition	DNA Damage Response Nucleoplasm DNA Repair Ubiquitin Conjugating Enzyme Activity DNA Metabolic Process Chromosome Nucleus Chromatin Organization Nucleic Acid Metabolic Process Chromosome, Telomeric Region Regulation Of DNA Metabolic Process Chromatin Remodeling Negative Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Metabolic Process Cellular Response To Stress Negative Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process Epigenetic Regulation Of Gene Expression Protein Polyubiquitination Protein K48-linked Ubiquitination Double-strand Break Repair Regulation Of Primary Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Chromosome Organization Enzyme Binding Modification-dependent Protein Catabolic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of DNA Metabolic Process Ubiquitin Protein Ligase Binding Post-translational Protein Modification Maintenance Of DNA Repeat Elements Heterochromatin Formation Negative Regulation Of DNA Recombination Chromatin Binding Protein Monoubiquitination Regulation Of Gene Expression Negative Regulation Of RNA Metabolic Process Positive Regulation Of DNA Metabolic Process Ubiquitin-dependent Protein Catabolic Process Macromolecule Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Single Guanine Insertion Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Ubiquitin-protein Transferase Activity Negative Regulation Of Gene Expression, Epigenetic
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