CUX1 and CCNB1

Number of citations of the paper that reports this interaction (PubMedID 20729212)
60

Data Source:
BioGRID (pull down, enzymatic study)

		CUX1	CCNB1
Description		cut like homeobox 1	cyclin B1
Image
GO Annotations	Cellular Component	Golgi Membrane Chromatin Nucleus Nucleoplasm Golgi Apparatus Cytosol Membrane	Spindle Pole Outer Kinetochore Nucleus Nucleoplasm Cytoplasm Mitochondrial Matrix Centrosome Microtubule Organizing Center Cytosol Cytoskeleton Membrane Cyclin B1-CDK1 Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	Patched Binding Protein Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Protein Kinase Binding Ubiquitin-like Protein Ligase Binding Cyclin-dependent Protein Serine/threonine Kinase Activator Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Intra-Golgi Vesicle-mediated Transport Positive Regulation Of Dendrite Morphogenesis	G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Oocyte Maturation In Utero Embryonic Development Mitotic Spindle Organization Mitotic Metaphase Chromosome Alignment Spermatogenesis Response To Xenobiotic Stimulus Response To Mechanical Stimulus Response To Toxic Substance Negative Regulation Of Gene Expression Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of MRNA 3'-end Processing Tissue Regeneration Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Positive Regulation Of Mitotic Cell Cycle Response To DDT Positive Regulation Of Fibroblast Proliferation Digestive Tract Development Cell Division Positive Regulation Of Attachment Of Spindle Microtubules To Kinetochore Ventricular Cardiac Muscle Cell Development Positive Regulation Of Cardiac Muscle Cell Proliferation Regulation Of Chromosome Condensation Protein-containing Complex Assembly Cellular Response To Iron(III) Ion Cellular Response To Fatty Acid Cellular Response To Hypoxia Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Positive Regulation Of Mitochondrial ATP Synthesis Coupled Electron Transport
Pathways		Signaling by cytosolic FGFR1 fusion mutants Signaling by FGFR1 in disease Intra-Golgi traffic	E2F-enabled inhibition of pre-replication complex formation Polo-like kinase mediated events Golgi Cisternae Pericentriolar Stack Reorganization APC/C:Cdc20 mediated degradation of Cyclin B Regulation of APC/C activators between G1/S and early anaphase Phosphorylation of the APC/C Phosphorylation of Emi1 Condensation of Prophase Chromosomes MASTL Facilitates Mitotic Progression Resolution of Sister Chromatid Cohesion Condensation of Prometaphase Chromosomes Regulation of PLK1 Activity at G2/M Transition Activation of NIMA Kinases NEK9, NEK6, NEK7 Initiation of Nuclear Envelope (NE) Reformation Nuclear Pore Complex (NPC) Disassembly Depolymerization of the Nuclear Lamina TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest Mitotic Prophase Cyclin A/B1/B2 associated events during G2/M transition G2/M DNA replication checkpoint Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex The role of GTSE1 in G2/M progression after G2 checkpoint Transcriptional regulation by RUNX2 Nuclear events stimulated by ALK signaling in cancer Regulation of MITF-M-dependent genes involved in cell cycle and proliferation
Drugs
Diseases
GWAS		Attention deficit hyperactivity disorder symptom score ( 27663945) Basal cell carcinoma ( 27539887 33549134 31174203) Breast cancer ( 29059683) Cerebellum cortex volume ( 31530798) Chronotype ( 30696823) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) HDL cholesterol levels ( 32203549) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Intelligence (MTAG) ( 29326435) Keratinocyte cancer (MTAG) ( 31174203) Mean platelet volume ( 32888494 27863252) Morning person ( 30696823) Platelet distribution width ( 32888494 27863252) Plateletcrit ( 32888494 27863252) Response to antidepressants ( 22584459) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 27863252 32888494) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		23 interacting genes: BIN1 CA12 CCNA1 CCNB1 CDC25A CDK1 CDK7 CHAF1B CREBBP CTSL CYTH2 EHMT2 ELAC2 GOLGA5 HMGB1 KAT2B MAX RB1 RECQL5 SATB1 SDC3 SUMO2 TLE4	64 interacting genes: ANAPC11 ARID4A BRCA1 BTG2 CCNB1IP1 CCNF CDC25A CDC25C CDC34 CDC6 CDH1 CDK1 CDKN1A CDKN1B CDT1 CEBPA CSNK2B CUX1 EP300 FLNA FZR1 GADD45A GADD45B GADD45G H1-1 H1-5 HERC5 ITPR1 KAT5 KPNB1 MAP4 MEF2C MOK NACC1 OGT OTUD7B PBK PCNA PIN1 PKMYT1 PLK1 PRC1 PRKDC PTCH1 PTMA RALBP1 RB1 RUNX2 TGFBR2 TP53BP1 TP73 TSC1 TSPYL2 TULP3 UBE2D2 UBE2N UBE3C UBE3D UCHL3 USP39 WEE1 XIAP XRCC6 ZFAND5
Entrez ID		1523	891
HPRD ID		00295	00454
Ensembl ID		ENSG00000257923	ENSG00000134057
Uniprot IDs		P39880 Q13948 Q3LIA3	P14635
PDB IDs		8WQE 8WQF 8WQI	2B9R 2JGZ 4Y72 4YC3 5HQ0 5LQF 6GU2 6GU3 6GU4 7NJ0 8TAR 8TAU 9FH9
Enriched GO Terms of Interacting Partners?		Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle DNA-binding Transcription Factor Binding Nucleoplasm Mitotic Cell Cycle Phase Transition Cyclin B1-CDK1 Complex Cell Division Chromatin Remodeling Mitotic DNA-templated DNA Replication Cyclin A1-CDK1 Complex Negative Regulation Of DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Biosynthetic Process Cell Cycle Phase Transition Regulation Of DNA Metabolic Process Regulation Of Attachment Of Spindle Microtubules To Kinetochore Mitotic DNA Replication N-terminal Peptidyl-lysine Acetylation Negative Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Chromatin Organization Positive Regulation Of Chromosome Segregation Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Nucleus Positive Regulation Of Cell Cycle G2/M Phase Transition Positive Regulation Of Mitochondrial ATP Synthesis Coupled Electron Transport Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Sister Chromatid Segregation Positive Regulation Of Cell Cycle Phase Transition Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell Cycle Process Positive Regulation Of Mitotic Cell Cycle Nuclear DNA Replication Regulation Of Chromosome Segregation Regulation Of Generation Of Precursor Metabolites And Energy Negative Regulation Of Macromolecule Metabolic Process Regulation Of Cell Cycle Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process G2/M Transition Of Mitotic Cell Cycle DNA Repair Cell Cycle G2/M Phase Transition Positive Regulation Of Cell Cycle Negative Regulation Of Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Ventricular Cardiac Muscle Cell Development	Regulation Of Cell Cycle Nucleoplasm Nucleus Regulation Of Protein Modification Process Intracellular Signal Transduction Negative Regulation Of Cell Cycle Regulation Of Primary Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Cell Cycle Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Regulation Of DNA Metabolic Process Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Phase Transition Negative Regulation Of Macromolecule Metabolic Process Regulation Of G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Negative Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of DNA Replication Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle G2/M Phase Transition Negative Regulation Of Cell Cycle Process Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Cell Cycle Phase Transition Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Protein Phosphorylation Regulation Of Catalytic Activity Positive Regulation Of DNA Replication Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Protein Modification Process Signal Transduction In Response To DNA Damage Regulation Of Phosphorus Metabolic Process Negative Regulation Of Cell Cycle G2/M Phase Transition Negative Regulation Of Mitotic Cell Cycle Regulation Of Phosphorylation Positive Regulation Of DNA Metabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Response To Stress Cell Division DNA Metabolic Process Regulation Of Protein Kinase Activity Negative Regulation Of DNA Metabolic Process Cyclin Binding Regulation Of Kinase Activity DNA Damage Response Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process
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