PPM1L and PDGFRB

Number of citations of the paper that reports this interaction (PubMedID 28065597)
51

Data Source:
BioGRID (two hybrid)

		PPM1L	PDGFRB
Description		protein phosphatase, Mg2+/Mn2+ dependent 1L	platelet derived growth factor receptor beta
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Membrane Extracellular Exosome	Nucleus Cytoplasm Lysosome Golgi Apparatus Plasma Membrane Focal Adhesion Membrane Apical Plasma Membrane Cytoplasmic Vesicle Lysosomal Lumen Receptor Complex
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Hydrolase Activity Cation Binding Metal Ion Binding	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Platelet Activating Factor Receptor Activity Platelet-derived Growth Factor Receptor Activity Platelet-derived Growth Factor Beta-receptor Activity GTPase Activator Activity Signaling Receptor Binding Platelet-derived Growth Factor Receptor Binding Protein Binding ATP Binding Kinase Activity Transferase Activity Enzyme Binding Protein Kinase Binding Vascular Endothelial Growth Factor Binding Platelet-derived Growth Factor Binding Phospholipase C Activator Activity
	Biological Process	MAPK Cascade Signal Transduction Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Sphingolipid Biosynthetic Process	Angiogenesis Chemotaxis Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Smooth Muscle Adaptation Positive Regulation Of Smooth Muscle Cell Migration Cell Migration Peptidyl-tyrosine Phosphorylation Positive Regulation Of Cell Migration Regulation Of Actin Cytoskeleton Organization Cell Migration Involved In Vasculogenesis Platelet-derived Growth Factor Receptor-beta Signaling Pathway Positive Regulation Of Metanephric Mesenchymal Cell Migration By Platelet-derived Growth Factor Receptor-beta Signaling Pathway Aorta Morphogenesis Cellular Response To Platelet-derived Growth Factor Stimulus Positive Regulation Of Cell Proliferation By VEGF-activated Platelet Derived Growth Factor Receptor Signaling Pathway Positive Regulation Of MAP Kinase Activity Positive Regulation Of Mitotic Nuclear Division Protein Autophosphorylation Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Calcium-mediated Signaling Positive Regulation Of Chemotaxis Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cardiac Myofibril Assembly Cell Chemotaxis Cell Migration Involved In Coronary Angiogenesis Retina Vasculature Development In Camera-type Eye Positive Regulation Of ERK1 And ERK2 Cascade Smooth Muscle Cell Chemotaxis Metanephric Glomerular Mesangial Cell Proliferation Involved In Metanephros Development Metanephric Glomerular Capillary Formation Positive Regulation Of Calcium Ion Import Positive Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of DNA Biosynthetic Process
Pathways		Sphingolipid de novo biosynthesis	PIP3 activates AKT signaling Downstream signal transduction Signaling by PDGF Constitutive Signaling by Aberrant PI3K in Cancer RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Drugs			Becaplermin Sorafenib Imatinib Dasatinib Sunitinib XL999 XL820 Pazopanib Midostaurin Regorafenib Nintedanib Polaprezinc Trapidil Foreskin fibroblast (neonatal) Tivozanib Fostamatinib Erdafitinib Pexidartinib Ripretinib Pralsetinib
Diseases			Glioma
GWAS		Kawasaki disease ( 22446961) Malaria ( 31844061) Metabolite levels ( 23823483) Morning person ( 30696823) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245) Response to methotrexate in rheumatoid arthritis ( 24583629)	Blood protein levels ( 30072576) Cytokine network levels (multivariate analysis) ( 31679650) Granulocyte percentage of myeloid white cells ( 27863252) Inflammatory biomarkers (multivariate analysis) ( 33110245) Monocyte count ( 27863252 32888494) Monocyte percentage of white cells ( 27863252 32888494)
Interacting Genes		3 interacting genes: EPHA2 MAP3K7 PDGFRB	78 interacting genes: ABL1 ABL2 ARAF BAG1 CAV1 CAV3 CBL CEP76 COPA COPB1 CRK EGFR EIF2AK2 ERBB2 FGFR1 FYN GAB1 GRB10 GRB14 GRB2 GRB7 ITGB3 JAK1 JAK2 KLHL12 KPRP KRT31 KRT34 KRTAP10-9 KRTAP12-3 KRTAP4-12 LCOR NCK1 NCK2 NEDD4 NHERF1 NHERF2 PDAP1 PDGFB PDGFD PDGFRA PIK3C2B PIK3CA PIK3R1 PIK3R2 PIK3R3 PLCG1 PPM1L PRDX2 PTEN PTK2 PTPN1 PTPN11 PTPN2 PTPN6 PTPRJ RAF1 RASA1 RPS6KB2 S1PR1 SHC1 SNX1 SNX2 SNX27 SNX4 SOCS1 SRC STAT1 STAT3 STAT5A STAT5B SYNGAP1 TNK2 TPTE TRIP6 TYK2 VAV1 YES1
Entrez ID		151742	5159
HPRD ID		17889	01423
Ensembl ID		ENSG00000163590	ENSG00000113721
Uniprot IDs		Q5SGD2	P09619 Q59F04
PDB IDs			1GQ5 1H9O 1SHA 2IUI 2L6W 2PLD 2PLE 3MJG
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Catalytic Activity Response To Growth Factor Positive Regulation Of MAP Kinase Activity Positive Regulation Of Smooth Muscle Cell Migration Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Locomotion Blood Vessel Morphogenesis Notochord Cell Development Positive Regulation Of Cell Migration Transmembrane Receptor Protein Tyrosine Kinase Activity Kinase Activity Protein Kinase Activity Regulation Of Catalytic Activity Positive Regulation Of Cell Motility Regulation Of Intracellular Signal Transduction Regulation Of MAPK Cascade Transferase Activity Cell Migration Involved In Coronary Angiogenesis Regulation Of Smooth Muscle Cell Migration Metanephric Glomerular Mesangial Cell Proliferation Involved In Metanephros Development Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Smooth Muscle Cell Proliferation Regulation Of MAP Kinase Activity Negative Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Protein Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Axial Mesoderm Formation Regulation Of Smooth Muscle Cell Proliferation Smooth Muscle Cell Chemotaxis Glomerular Mesangial Cell Proliferation Platelet-derived Growth Factor Beta-receptor Activity Platelet-derived Growth Factor Receptor Activity Negative Regulation Of Lymphangiogenesis Regulation Of Cell Migration Notochord Formation Positive Regulation Of Metanephric Mesenchymal Cell Migration Phospholipase C Activator Activity Positive Regulation Of Cell Proliferation By VEGF-activated Platelet Derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Metanephric Mesenchymal Cell Migration By Platelet-derived Growth Factor Receptor-beta Signaling Pathway Metanephric Glomerular Capillary Formation Platelet Activating Factor Receptor Activity I-kappaB Phosphorylation Linear Polyubiquitin Binding Receptor Complex Regulation Of Cell Motility Cell Chemotaxis Regulation Of Locomotion Cell Migration Involved In Vasculogenesis	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Signal Transduction Phosphotyrosine Residue Binding Regulation Of Cell Adhesion ERBB Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Cytosol Positive Regulation Of Cell Adhesion Non-membrane Spanning Protein Tyrosine Kinase Activity Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Signal Transduction Protein Tyrosine Kinase Activity Regulation Of Signal Transduction Regulation Of MAPK Cascade Regulation Of Multicellular Organismal Process Intracellular Signal Transduction Regulation Of Signaling Regulation Of Cell Communication Insulin Receptor Signaling Pathway Regulation Of Cell-cell Adhesion Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Cell Migration Growth Hormone Receptor Signaling Pathway Regulation Of Apoptotic Process Regulation Of Locomotion Cellular Response To Growth Factor Stimulus Positive Regulation Of Cell Migration Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Cell-cell Adhesion Regulation Of T Cell Activation Regulation Of Programmed Cell Death Regulation Of Cell Motility Regulation Of Immune System Process Positive Regulation Of Cell Motility T Cell Activation Cell Activation Ephrin Receptor Binding Receptor Tyrosine Kinase Binding Positive Regulation Of Locomotion Positive Regulation Of T Cell Activation Cell Migration Response To Growth Factor Positive Regulation Of Multicellular Organismal Process Regulation Of Biological Quality
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