PPM1L

Description		protein phosphatase, Mg2+/Mn2+ dependent 1L
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Membrane Extracellular Exosome
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Hydrolase Activity Cation Binding Metal Ion Binding
	Biological Process	MAPK Cascade Signal Transduction Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Sphingolipid Biosynthetic Process
Pathways		Sphingolipid de novo biosynthesis
Drugs
Diseases
GWAS		Kawasaki disease ( 22446961) Malaria ( 31844061) Metabolite levels ( 23823483) Morning person ( 30696823) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245) Response to methotrexate in rheumatoid arthritis ( 24583629)
Novel Interacting Genes		1 novel interacting genes: TRIM59
Interacting Genes		3 interacting genes: EPHA2 MAP3K7 PDGFRB
Entrez ID		151742
HPRD ID		17889
Ensembl ID		ENSG00000163590
Uniprot IDs		Q5SGD2
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Catalytic Activity Response To Growth Factor Positive Regulation Of MAP Kinase Activity Positive Regulation Of Smooth Muscle Cell Migration Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Locomotion Blood Vessel Morphogenesis Notochord Cell Development Positive Regulation Of Cell Migration Transmembrane Receptor Protein Tyrosine Kinase Activity Kinase Activity Protein Kinase Activity Regulation Of Catalytic Activity Positive Regulation Of Cell Motility Regulation Of Intracellular Signal Transduction Regulation Of MAPK Cascade Transferase Activity Cell Migration Involved In Coronary Angiogenesis Regulation Of Smooth Muscle Cell Migration Metanephric Glomerular Mesangial Cell Proliferation Involved In Metanephros Development Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Smooth Muscle Cell Proliferation Regulation Of MAP Kinase Activity Negative Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Protein Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Axial Mesoderm Formation Regulation Of Smooth Muscle Cell Proliferation Smooth Muscle Cell Chemotaxis Glomerular Mesangial Cell Proliferation Platelet-derived Growth Factor Beta-receptor Activity Platelet-derived Growth Factor Receptor Activity Negative Regulation Of Lymphangiogenesis Regulation Of Cell Migration Notochord Formation Positive Regulation Of Metanephric Mesenchymal Cell Migration Phospholipase C Activator Activity Positive Regulation Of Cell Proliferation By VEGF-activated Platelet Derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Metanephric Mesenchymal Cell Migration By Platelet-derived Growth Factor Receptor-beta Signaling Pathway Metanephric Glomerular Capillary Formation Platelet Activating Factor Receptor Activity I-kappaB Phosphorylation Linear Polyubiquitin Binding Receptor Complex Regulation Of Cell Motility Cell Chemotaxis Regulation Of Locomotion Cell Migration Involved In Vasculogenesis
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