PPM1L

Gene Name		protein phosphatase, Mg2+/Mn2+ dependent, 1L
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Membrane Integral Component Of Membrane Extracellular Vesicular Exosome
	Molecular Function	Protein Serine/threonine Phosphatase Activity Metal Ion Binding
	Biological Process	MAPK Cascade Protein Dephosphorylation Sphingolipid Metabolic Process Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Sphingolipid Biosynthetic Process Small Molecule Metabolic Process
Pathways		Sphingolipid metabolism Metabolism of lipids and lipoproteins Sphingolipid de novo biosynthesis
Drugs
Diseases
GWAS		Kawasaki disease ( 22446961)
Protein-protein Interactions		1 interactors: MAP3K7
Entrez ID		151742
HPRD ID		17889
Ensembl ID
Uniprot IDs		Q5SGD2
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Ripoptosome Assembly Involved In Necroptotic Process Negative Regulation Of Necroptotic Process I-kappaB Phosphorylation Negative Regulation Of Necrotic Cell Death Regulation Of Necroptotic Process Positive Regulation Of T Cell Cytokine Production Regulation Of Necrotic Cell Death Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Regulation Of T Cell Cytokine Production Activation Of NF-kappaB-inducing Kinase Activity Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Interleukin-2 Production Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway NIK/NF-kappaB Signaling Regulation Of NIK/NF-kappaB Signaling Histone H3 Acetylation Positive Regulation Of Cytokine Production Involved In Immune Response Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Activation Of MAPKK Activity MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of JUN Kinase Activity Regulation Of Cytokine Production Involved In Immune Response Toll-like Receptor 4 Signaling Pathway Regulation Of JUN Kinase Activity JNK Cascade Positive Regulation Of T Cell Mediated Immunity Toll-like Receptor Signaling Pathway T Cell Receptor Signaling Pathway Histone Acetylation Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Positive Regulation Of JNK Cascade Positive Regulation Of NF-kappaB Transcription Factor Activity Internal Protein Amino Acid Acetylation Neural Tube Formation Pattern Recognition Receptor Signaling Pathway Negative Regulation Of Protein Complex Assembly Innate Immune Response-activating Signal Transduction Protein Acetylation
Tagcloud ?		encodes endoplasmic epithelium er gland highly impairs induces inositol involving ire1 lactating lactation mammary milk named phosphatase physiological possibly pp2ce regulates regulator requiring reticulum stress targeted towards unfolded upr