BGLAP and CTSH

Number of citations of the paper that reports this interaction (PubMedID 9076588)
0

Data Source:
HPRD (in vivo)

		BGLAP	CTSH
Description		bone gamma-carboxyglutamate protein	cathepsin H
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Endoplasmic Reticulum Lumen Golgi Lumen Dendrite Vesicle Cell Projection Perikaryon	Outer Dense Fiber Acrosomal Vesicle Extracellular Region Extracellular Space Lysosome Cytosol Axoneme Extracellular Matrix Secretory Granule Lumen Cytoplasmic Ribonucleoprotein Granule Extracellular Exosome Alveolar Lamellar Body Multivesicular Body Lumen Tertiary Granule Lumen Ficolin-1-rich Granule Lumen
	Molecular Function	Hormone Activity Structural Molecule Activity Calcium Ion Binding Protein Binding Structural Constituent Of Bone Hydroxyapatite Binding Metal Ion Binding	Endopeptidase Activity Aminopeptidase Activity Cysteine-type Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Peptidase Activator Activity Involved In Apoptotic Process Hydrolase Activity HLA-A Specific Activating MHC Class I Receptor Activity Kininogen Binding Identical Protein Binding Protein-containing Complex Binding Thyroid Hormone Binding
	Biological Process	Skeletal System Development Ossification Osteoblast Differentiation Positive Regulation Of Neurotransmitter Secretion Cell Adhesion Signal Transduction Brain Development Learning Or Memory Response To Xenobiotic Stimulus Response To Mechanical Stimulus Response To Gravity Response To Zinc Ion Response To Activity Bone Mineralization Regulation Of Bone Mineralization Biomineral Tissue Development Response To Nutrient Levels Response To Vitamin K Response To Insulin Cellular Response To Insulin Stimulus Response To Vitamin D Response To Testosterone Response To Hydroxyisoflavone Cellular Response To Zinc Ion Starvation Response To Macrophage Colony-stimulating Factor Glucose Homeostasis Response To Estrogen Type B Pancreatic Cell Proliferation Regulation Of Bone Resorption Response To Ethanol Regulation Of Osteoclast Differentiation System Development Stem Cell Differentiation Cognition Response To Glucocorticoid Bone Development Cellular Response To Vitamin D Cellular Response To Growth Factor Stimulus Regulation Of Cellular Response To Insulin Stimulus Negative Regulation Of Bone Development Regulation Of Testosterone Biosynthetic Process	Metanephros Development T Cell Mediated Cytotoxicity Adaptive Immune Response Immune Response-regulating Signaling Pathway Proteolysis Apoptotic Process Immune Response Spermatogenesis Positive Regulation Of Gene Expression Positive Regulation Of Epithelial Cell Migration Neuropeptide Catabolic Process Bradykinin Catabolic Process Antigen Processing And Presentation Positive Regulation Of Cell Migration Zymogen Activation Protein Destabilization Response To Retinoic Acid Membrane Protein Proteolysis Surfactant Homeostasis Proteolysis Involved In Protein Catabolic Process Dichotomous Subdivision Of Terminal Units Involved In Lung Branching ERK1 And ERK2 Cascade Cellular Response To Thyroid Hormone Stimulus Lysosomal Protein Catabolic Process Response To Odorant Positive Regulation Of Apoptotic Signaling Pathway
Pathways		Gamma-carboxylation of protein precursors Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus Removal of aminoterminal propeptides from gamma-carboxylated proteins RUNX2 regulates osteoblast differentiation	MHC class II antigen presentation Surfactant metabolism Neutrophil degranulation
Drugs		Menadione Phylloquinone gamma-carboxy-L-glutamic acid Gallium nitrate	N1-(1-Dimethylcarbamoyl-2-Phenyl-Ethyl)-2-Oxo-N4-(2-Pyridin-2-Yl-Ethyl)-Succinamide p-Toluenesulfonic acid N-[1-Hydroxycarboxyethyl-Carbonyl]Leucylamino-2-Methyl-Butane CARBOBENZYLOXY-(L)-LEUCINYL-(L)LEUCINYL METHOXYMETHYLKETONE
Diseases			Type I diabetes mellitus
GWAS		Estimated glomerular filtration rate ( 30604766) Mean corpuscular hemoglobin concentration ( 20139978) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) White matter hyperintensity burden ( 25663218)	Aspartate aminotransferase levels ( 33547301) Autoimmune traits (pleiotropy) ( 30572963) Basal cell carcinoma ( 31174203) Bipolar disorder ( 21771265) Blood protein levels ( 30072576) Celiac disease ( 30572963) Keratinocyte cancer (MTAG) ( 31174203) Multiple sclerosis ( 24076602 31604244) Narcolepsy ( 23459209) Type 1 diabetes ( 18978792 19430480 25751624 30572963)
Interacting Genes		6 interacting genes: ASPH CTSB CTSD CTSH CTSS GGCX	5 interacting genes: BGLAP CSTA CSTB SFTPB XRN1
Entrez ID		632	1512
HPRD ID		00205	00288
Ensembl ID		ENSG00000242252	ENSG00000103811
Uniprot IDs		P02818	E9PKT6 P09668
PDB IDs		8XS1 9BUR 9BUX	6CZK 6CZS
Enriched GO Terms of Interacting Partners?		Cysteine-type Endopeptidase Activity Cellular Response To Thyroid Hormone Stimulus Ficolin-1-rich Granule Lumen Response To Thyroid Hormone Tertiary Granule Lumen Endolysosome Lumen Endopeptidase Activity Antigen Processing And Presentation Extracellular Matrix Peptidase Activity Proteoglycan Binding Lysosome Cysteine-type Peptidase Activity Positive Regulation Of Cation Channel Activity Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Positive Regulation Of Ion Transmembrane Transporter Activity Positive Regulation Of Transporter Activity Collagen Catabolic Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Antigen Processing And Presentation Of Exogenous Antigen Protein Maturation Cellular Response To Hormone Stimulus Collagen Metabolic Process Collagen Binding Antigen Processing And Presentation Of Peptide Antigen Proteolysis Regulation Of Transmembrane Transporter Activity Regulation Of Monoatomic Ion Transmembrane Transporter Activity HLA-A Specific Activating MHC Class I Receptor Activity Gamma-glutamyl Carboxylase Activity Lysosomal Lumen Melanosome Peptidyl-aspartic Acid 3-dioxygenase Activity Positive Regulation Of Cation Transmembrane Transport Extracellular Space Aspartic-type Peptidase Activity Kininogen Binding Vitamin Binding Negative Regulation Of Bone Development Positive Regulation Of Monoatomic Ion Transmembrane Transport Protein Metabolic Process Response To Hormone Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Hydrolase Activity Response To Odorant Dichotomous Subdivision Of Terminal Units Involved In Lung Branching Basement Membrane Disassembly Negative Regulation Of Testosterone Biosynthetic Process	Response To Testosterone Cysteine-type Endopeptidase Inhibitor Activity Endopeptidase Inhibitor Activity Extracellular Space Peptidase Inhibitor Activity Protease Binding Negative Regulation Of Protein Metabolic Process Cellular Response To Puromycin Cellular Response To Cycloheximide Negative Regulation Of Bone Development Structural Constituent Of Bone Negative Regulation Of Proteolysis Hydroxyapatite Binding Response To Vitamin K Response To Hydroxyisoflavone Response To Gravity Response To Phenylpropanoid Response To Ketone Regulation Of Testosterone Biosynthetic Process Cellular Response To Zinc Ion Starvation Peptidase Inhibitor Complex Multivesicular Body Lumen Lamellar Body Alveolar Lamellar Body Response To Cycloheximide 5'-3' RNA Exonuclease Activity Response To Alcohol G-quadruplex RNA Binding Response To Macrophage Colony-stimulating Factor G-quadruplex DNA Binding Regulation Of Bone Development 5'-3' Exonuclease Activity Cellular Response To Vitamin D Nuclear MRNA Surveillance Histone MRNA Catabolic Process Regulation Of Proteolysis RRNA Catabolic Process Type B Pancreatic Cell Proliferation Peptide Cross-linking Positive Regulation Of Neurotransmitter Secretion Regulation Of Ketone Biosynthetic Process Regulation Of Protein Metabolic Process Negative Regulation Of Telomere Maintenance Via Telomerase Telomerase RNA Binding Clathrin-coated Endocytic Vesicle Dendrite Histone MRNA Metabolic Process Response To Vitamin D Respiratory Gaseous Exchange By Respiratory System Negative Regulation Of Telomere Maintenance Via Telomere Lengthening
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