BGLAP

Description		bone gamma-carboxyglutamate protein
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Endoplasmic Reticulum Lumen Golgi Lumen Dendrite Vesicle Cell Projection Perikaryon
	Molecular Function	Hormone Activity Structural Molecule Activity Calcium Ion Binding Protein Binding Structural Constituent Of Bone Hydroxyapatite Binding Metal Ion Binding
	Biological Process	Skeletal System Development Ossification Osteoblast Differentiation Positive Regulation Of Neurotransmitter Secretion Cell Adhesion Signal Transduction Brain Development Learning Or Memory Response To Xenobiotic Stimulus Response To Mechanical Stimulus Response To Gravity Response To Zinc Ion Response To Activity Bone Mineralization Regulation Of Bone Mineralization Biomineral Tissue Development Response To Nutrient Levels Response To Vitamin K Response To Insulin Cellular Response To Insulin Stimulus Response To Vitamin D Response To Testosterone Response To Hydroxyisoflavone Cellular Response To Zinc Ion Starvation Response To Macrophage Colony-stimulating Factor Glucose Homeostasis Response To Estrogen Type B Pancreatic Cell Proliferation Regulation Of Bone Resorption Response To Ethanol Regulation Of Osteoclast Differentiation System Development Stem Cell Differentiation Cognition Response To Glucocorticoid Bone Development Cellular Response To Vitamin D Cellular Response To Growth Factor Stimulus Regulation Of Cellular Response To Insulin Stimulus Negative Regulation Of Bone Development Regulation Of Testosterone Biosynthetic Process
Pathways		Gamma-carboxylation of protein precursors Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus Removal of aminoterminal propeptides from gamma-carboxylated proteins RUNX2 regulates osteoblast differentiation
Drugs		Menadione Phylloquinone gamma-carboxy-L-glutamic acid Gallium nitrate
Diseases
GWAS		Estimated glomerular filtration rate ( 30604766) Mean corpuscular hemoglobin concentration ( 20139978) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) White matter hyperintensity burden ( 25663218)
Interacting Genes		6 interacting genes: ASPH CTSB CTSD CTSH CTSS GGCX
Entrez ID		632
HPRD ID		00205
Ensembl ID		ENSG00000242252
Uniprot IDs		P02818
PDB IDs		8XS1 9BUR 9BUX
Enriched GO Terms of Interacting Partners?		Cysteine-type Endopeptidase Activity Cellular Response To Thyroid Hormone Stimulus Ficolin-1-rich Granule Lumen Response To Thyroid Hormone Tertiary Granule Lumen Endolysosome Lumen Endopeptidase Activity Antigen Processing And Presentation Extracellular Matrix Peptidase Activity Proteoglycan Binding Lysosome Cysteine-type Peptidase Activity Positive Regulation Of Cation Channel Activity Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Positive Regulation Of Ion Transmembrane Transporter Activity Positive Regulation Of Transporter Activity Collagen Catabolic Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Antigen Processing And Presentation Of Exogenous Antigen Protein Maturation Cellular Response To Hormone Stimulus Collagen Metabolic Process Collagen Binding Antigen Processing And Presentation Of Peptide Antigen Proteolysis Regulation Of Transmembrane Transporter Activity Regulation Of Monoatomic Ion Transmembrane Transporter Activity HLA-A Specific Activating MHC Class I Receptor Activity Gamma-glutamyl Carboxylase Activity Lysosomal Lumen Melanosome Peptidyl-aspartic Acid 3-dioxygenase Activity Positive Regulation Of Cation Transmembrane Transport Extracellular Space Aspartic-type Peptidase Activity Kininogen Binding Vitamin Binding Negative Regulation Of Bone Development Positive Regulation Of Monoatomic Ion Transmembrane Transport Protein Metabolic Process Response To Hormone Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Hydrolase Activity Response To Odorant Dichotomous Subdivision Of Terminal Units Involved In Lung Branching Basement Membrane Disassembly Negative Regulation Of Testosterone Biosynthetic Process
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