RC3H1 and UBE2A

Number of citations of the paper that reports this interaction (PubMedID 26489670)
51

Data Source:
BioGRID (pull down)

		RC3H1	UBE2A
Description		ring finger and CCCH-type domains 1	ubiquitin conjugating enzyme E2 A
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GO Annotations	Cellular Component	P-body Cytoplasm Cytoplasmic Stress Granule	Chromatin Nucleoplasm Lysosome Endosome Late Endosome Cytosol HULC Complex
	Molecular Function	RNA Binding Double-stranded RNA Binding MRNA Binding MRNA 3'-UTR Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity MiRNA Binding RNA Stem-loop Binding Metal Ion Binding Ubiquitin Protein Ligase Activity CCR4-NOT Complex Binding	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Ubiquitin-like Protein Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin Binding Ubiquitin Conjugating Enzyme Activity
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Protein Polyubiquitination Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process B Cell Homeostasis Regulation Of Germinal Center Formation Negative Regulation Of Germinal Center Formation Ubiquitin-dependent Protein Catabolic Process Regulation Of Gene Expression Post-transcriptional Regulation Of Gene Expression Protein Ubiquitination Negative Regulation Of B Cell Proliferation P-body Assembly T Cell Proliferation T Cell Homeostasis Regulation Of MRNA Stability Negative Regulation Of T-helper Cell Differentiation Negative Regulation Of Activated T Cell Proliferation Lymph Node Development Spleen Development T Cell Receptor Signaling Pathway Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of MRNA Catabolic Process 3'-UTR-mediated MRNA Destabilization T Follicular Helper Cell Differentiation Cellular Response To Interleukin-1 Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Negative Regulation Of T-helper 17 Cell Differentiation Regulation Of MiRNA Metabolic Process	G2/M Transition Of Mitotic Cell Cycle Protein Polyubiquitination Cytoplasmic Translation DNA Repair Postreplication Repair Chromatin Organization Chromatin Remodeling Ubiquitin-dependent Protein Catabolic Process DNA Damage Response Response To UV Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Positive Regulation Of Mitophagy
Pathways			Synthesis of active ubiquitin: roles of E1 and E2 enzymes E3 ubiquitin ligases ubiquitinate target proteins Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Femur bone mineral density x serum urate levels interaction ( 34046847)	Brain connectivity ( 23471985)
Interacting Genes		14 interacting genes: ICOS TNF TNFRSF4 UBE2A UBE2B UBE2D2 UBE2F UBE2G1 UBE2G2 UBE2L3 UBE2N UBE2V1 UBE2V2 UCP3	32 interacting genes: CBX5 CDK1 CDK2 CDK9 CDKN2A CRMP1 EEF1D H2BC21 H2BC3 HECTD3 HLTF KCMF1 MDM2 PCNA PRKN PSMG1 RAD18 RC3H1 RNF167 RNF20 RNF4 RNF40 SDCBP TP53 TRIM27 UBA1 UBA6 UBC UBR1 UBR3 UBR5 ZMYM2
Entrez ID		149041	7319
HPRD ID		13913	02422
Ensembl ID		ENSG00000135870	ENSG00000077721
Uniprot IDs		B7ZMB3 B9EGU6 Q5TC82	A0A0D9SG71 P49459
PDB IDs		3X1O 4QIK 4QIL 4ULW 4YWQ 8RHS	6CYO 6CYR 8BTL 8IEJ
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Postreplication Repair Protein Ubiquitination Ubiquitin-protein Transferase Activity UBC13-MMS2 Complex Ubiquitin-like Protein Transferase Activity Ubiquitin Conjugating Enzyme Complex Protein K63-linked Ubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Protein K48-linked Ubiquitination Positive Regulation Of Protein K63-linked Ubiquitination Protein Modification Process Regulation Of Protein K63-linked Ubiquitination Positive Regulation Of Protein Polyubiquitination Macromolecule Catabolic Process Error-free Postreplication DNA Repair Proteolysis Regulation Of Post-translational Protein Modification Proteasomal Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Regulation Of Protein Polyubiquitination Ubiquitin Protein Ligase Binding Positive Regulation Of Post-translational Protein Modification ATP Binding Protein K11-linked Ubiquitination Protein Catabolic Process Regulation Of Protein Modification Process HULC Complex Positive Regulation Of Protein Modification Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Metabolic Process Regulation Of Protein Ubiquitination Nucleotide Binding Transferase Activity DNA Damage Response Response To Stress Ubiquitin-protein Transferase Activator Activity Regulation Of DNA Metabolic Process DNA Repair Catabolic Process Positive Regulation Of DNA Metabolic Process Ubiquitin Ligase Complex Cellular Response To Stress Macromolecule Metabolic Process Response To Glucocorticoid	Post-translational Protein Modification Protein Ubiquitination Protein Modification By Small Protein Conjugation Ubiquitin Protein Ligase Activity Protein Modification Process Ubiquitin-protein Transferase Activity Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Protein Polyubiquitination Protein Metabolic Process Cellular Response To Stress Macromolecule Catabolic Process Transferase Activity DNA Damage Response Proteolysis Catabolic Process Chromatin Organization Protein K63-linked Ubiquitination Macromolecule Metabolic Process Response To Stress Nucleoplasm PML Body Zinc Ion Binding Ubiquitin Protein Ligase Binding Chromatin Remodeling Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Response To Oxidative Stress Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K29-linked Ubiquitination Ubiquitin Ligase Complex Regulation Of Transcription By RNA Polymerase II Proteasomal Protein Catabolic Process Nucleus DNA Repair Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process SUMO Transferase Activity Positive Regulation Of Metabolic Process Cellular Response To Hydrogen Peroxide Protein Autoubiquitination Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription P53 Binding Regulation Of RNA Biosynthetic Process Cyclin-dependent Protein Kinase Activity Cellular Response To Actinomycin D Ubiquitin Activating Enzyme Activity Negative Regulation Of DNA-templated Transcription
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