RC3H1 and TNFRSF4

Number of citations of the paper that reports this interaction (PubMedID 29352114)
56

Data Source:
BioGRID (unspecified method)

		RC3H1	TNFRSF4
Description		ring finger and CCCH-type domains 1	TNF receptor superfamily member 4
Image
GO Annotations	Cellular Component	P-body Cytoplasm Cytoplasmic Stress Granule	Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane
	Molecular Function	RNA Binding Double-stranded RNA Binding MRNA Binding MRNA 3'-UTR Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity MiRNA Binding RNA Stem-loop Binding Metal Ion Binding Ubiquitin Protein Ligase Activity CCR4-NOT Complex Binding	Virus Receptor Activity Tumor Necrosis Factor Receptor Activity Protein Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Protein Polyubiquitination Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process B Cell Homeostasis Regulation Of Germinal Center Formation Negative Regulation Of Germinal Center Formation Ubiquitin-dependent Protein Catabolic Process Regulation Of Gene Expression Post-transcriptional Regulation Of Gene Expression Protein Ubiquitination Negative Regulation Of B Cell Proliferation P-body Assembly T Cell Proliferation T Cell Homeostasis Regulation Of MRNA Stability Negative Regulation Of T-helper Cell Differentiation Negative Regulation Of Activated T Cell Proliferation Lymph Node Development Spleen Development T Cell Receptor Signaling Pathway Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of MRNA Catabolic Process 3'-UTR-mediated MRNA Destabilization T Follicular Helper Cell Differentiation Cellular Response To Interleukin-1 Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Negative Regulation Of T-helper 17 Cell Differentiation Regulation Of MiRNA Metabolic Process	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Immunoglobulin Production Inflammatory Response Immune Response Positive Regulation Of B Cell Proliferation Tumor Necrosis Factor-mediated Signaling Pathway T Cell Proliferation Symbiont Entry Into Host Cell
Pathways			TNFs bind their physiological receptors
Drugs
Diseases
GWAS		Femur bone mineral density x serum urate levels interaction ( 34046847)	Inflammatory bowel disease ( 23128233)
Interacting Genes		14 interacting genes: ICOS TNF TNFRSF4 UBE2A UBE2B UBE2D2 UBE2F UBE2G1 UBE2G2 UBE2L3 UBE2N UBE2V1 UBE2V2 UCP3	10 interacting genes: NUFIP2 RC3H1 SIVA1 TNFRSF9 TNFSF4 TRAF1 TRAF2 TRAF3 TRAF4 TRAF5
Entrez ID		149041	7293
HPRD ID		13913	02636
Ensembl ID		ENSG00000135870	ENSG00000186827
Uniprot IDs		B7ZMB3 B9EGU6 Q5TC82	A0A8V8TQH5 P43489
PDB IDs		3X1O 4QIK 4QIL 4ULW 4YWQ 8RHS	1D0A 2HEV 2HEY 6OGX 6OKM 6OKN 7YK4 8AG1
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Postreplication Repair Protein Ubiquitination Ubiquitin-protein Transferase Activity UBC13-MMS2 Complex Ubiquitin-like Protein Transferase Activity Ubiquitin Conjugating Enzyme Complex Protein K63-linked Ubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Protein K48-linked Ubiquitination Positive Regulation Of Protein K63-linked Ubiquitination Protein Modification Process Regulation Of Protein K63-linked Ubiquitination Positive Regulation Of Protein Polyubiquitination Macromolecule Catabolic Process Error-free Postreplication DNA Repair Proteolysis Regulation Of Post-translational Protein Modification Proteasomal Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Regulation Of Protein Polyubiquitination Ubiquitin Protein Ligase Binding Positive Regulation Of Post-translational Protein Modification ATP Binding Protein K11-linked Ubiquitination Protein Catabolic Process Regulation Of Protein Modification Process HULC Complex Positive Regulation Of Protein Modification Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Metabolic Process Regulation Of Protein Ubiquitination Nucleotide Binding Transferase Activity DNA Damage Response Response To Stress Ubiquitin-protein Transferase Activator Activity Regulation Of DNA Metabolic Process DNA Repair Catabolic Process Positive Regulation Of DNA Metabolic Process Ubiquitin Ligase Complex Cellular Response To Stress Macromolecule Metabolic Process Response To Glucocorticoid	Tumor Necrosis Factor Receptor Binding Thioesterase Binding Tumor Necrosis Factor-mediated Signaling Pathway Signaling Adaptor Activity CD40 Receptor Complex Regulation Of Canonical NF-kappaB Signal Transduction Apoptotic Process Programmed Cell Death Cell Death Ubiquitin Protein Ligase Binding Regulation Of MRNA Metabolic Process Tumor Necrosis Factor Receptor Superfamily Binding Regulation Of DNA-binding Transcription Factor Activity Regulation Of MRNA Stability MRNA Stabilization CD40 Signaling Pathway Interleukin-17-mediated Signaling Pathway Cytokine-mediated Signaling Pathway Regulation Of RNA Stability Cell Surface Receptor Signaling Pathway Negative Regulation Of MRNA Catabolic Process RNA Stabilization Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of RNA Catabolic Process Protein Phosphatase Binding Negative Regulation Of MRNA Metabolic Process Cytoplasmic Side Of Plasma Membrane Positive Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of T-helper Cell Differentiation Regulation Of Immune Response Post-transcriptional Regulation Of Gene Expression Negative Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Zinc Ion Binding Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of T Cell Cytokine Production Ubiquitin Protein Ligase Activity Negative Regulation Of Alpha-beta T Cell Differentiation Regulation Of Intracellular Signal Transduction Positive Regulation Of Immune Response Negative Regulation Of CD4-positive, Alpha-beta T Cell Activation Regulation Of Immune System Process Signal Transduction Involved In Regulation Of Gene Expression Positive Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Cell Population Proliferation Positive Regulation Of Interleukin-12 Production Regulation Of T Cell Proliferation TORC2 Complex Disassembly Regulation Of T Cell Cytokine Production
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