RC3H1

Description		ring finger and CCCH-type domains 1
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GO Annotations	Cellular Component	P-body Cytoplasm Cytoplasmic Stress Granule
	Molecular Function	RNA Binding Double-stranded RNA Binding MRNA Binding MRNA 3'-UTR Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity MiRNA Binding RNA Stem-loop Binding Metal Ion Binding Ubiquitin Protein Ligase Activity CCR4-NOT Complex Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Protein Polyubiquitination Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process B Cell Homeostasis Regulation Of Germinal Center Formation Negative Regulation Of Germinal Center Formation Ubiquitin-dependent Protein Catabolic Process Regulation Of Gene Expression Post-transcriptional Regulation Of Gene Expression Protein Ubiquitination Negative Regulation Of B Cell Proliferation P-body Assembly T Cell Proliferation T Cell Homeostasis Regulation Of MRNA Stability Negative Regulation Of T-helper Cell Differentiation Negative Regulation Of Activated T Cell Proliferation Lymph Node Development Spleen Development T Cell Receptor Signaling Pathway Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of MRNA Catabolic Process 3'-UTR-mediated MRNA Destabilization T Follicular Helper Cell Differentiation Cellular Response To Interleukin-1 Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Negative Regulation Of T-helper 17 Cell Differentiation Regulation Of MiRNA Metabolic Process
Pathways
Drugs
Diseases
GWAS		Femur bone mineral density x serum urate levels interaction ( 34046847)
Interacting Genes		14 interacting genes: ICOS TNF TNFRSF4 UBE2A UBE2B UBE2D2 UBE2F UBE2G1 UBE2G2 UBE2L3 UBE2N UBE2V1 UBE2V2 UCP3
Entrez ID		149041
HPRD ID		13913
Ensembl ID		ENSG00000135870
Uniprot IDs		B7ZMB3 B9EGU6 Q5TC82
PDB IDs		3X1O 4QIK 4QIL 4ULW 4YWQ 8RHS
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Postreplication Repair Protein Ubiquitination Ubiquitin-protein Transferase Activity UBC13-MMS2 Complex Ubiquitin-like Protein Transferase Activity Ubiquitin Conjugating Enzyme Complex Protein K63-linked Ubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Protein K48-linked Ubiquitination Positive Regulation Of Protein K63-linked Ubiquitination Protein Modification Process Regulation Of Protein K63-linked Ubiquitination Positive Regulation Of Protein Polyubiquitination Macromolecule Catabolic Process Error-free Postreplication DNA Repair Proteolysis Regulation Of Post-translational Protein Modification Proteasomal Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Regulation Of Protein Polyubiquitination Ubiquitin Protein Ligase Binding Positive Regulation Of Post-translational Protein Modification ATP Binding Protein K11-linked Ubiquitination Protein Catabolic Process Regulation Of Protein Modification Process HULC Complex Positive Regulation Of Protein Modification Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Metabolic Process Regulation Of Protein Ubiquitination Nucleotide Binding Transferase Activity DNA Damage Response Response To Stress Ubiquitin-protein Transferase Activator Activity Regulation Of DNA Metabolic Process DNA Repair Catabolic Process Positive Regulation Of DNA Metabolic Process Ubiquitin Ligase Complex Cellular Response To Stress Macromolecule Metabolic Process Response To Glucocorticoid
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