RC3H1 and ICOS

Number of citations of the paper that reports this interaction (PubMedID 29352114)
56

Data Source:
BioGRID (unspecified method)

		RC3H1	ICOS
Description		ring finger and CCCH-type domains 1	inducible T cell costimulator
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GO Annotations	Cellular Component	P-body Cytoplasm Cytoplasmic Stress Granule	Extracellular Region Plasma Membrane Membrane
	Molecular Function	RNA Binding Double-stranded RNA Binding MRNA Binding MRNA 3'-UTR Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity MiRNA Binding RNA Stem-loop Binding Metal Ion Binding Ubiquitin Protein Ligase Activity CCR4-NOT Complex Binding	Protein Binding Signaling Receptor Activity
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Protein Polyubiquitination Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process B Cell Homeostasis Regulation Of Germinal Center Formation Negative Regulation Of Germinal Center Formation Ubiquitin-dependent Protein Catabolic Process Regulation Of Gene Expression Post-transcriptional Regulation Of Gene Expression Protein Ubiquitination Negative Regulation Of B Cell Proliferation P-body Assembly T Cell Proliferation T Cell Homeostasis Regulation Of MRNA Stability Negative Regulation Of T-helper Cell Differentiation Negative Regulation Of Activated T Cell Proliferation Lymph Node Development Spleen Development T Cell Receptor Signaling Pathway Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of MRNA Catabolic Process 3'-UTR-mediated MRNA Destabilization T Follicular Helper Cell Differentiation Cellular Response To Interleukin-1 Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Negative Regulation Of T-helper 17 Cell Differentiation Regulation Of MiRNA Metabolic Process	T Cell Tolerance Induction Immune Response T Cell Costimulation T Follicular Helper Cell Differentiation Cell-cell Adhesion
Pathways			Nuclear events stimulated by ALK signaling in cancer
Drugs
Diseases			Common variable immunodeficiency (CVID), including the following four diseases: Inducible T Cell costimulator (ICOS) defect; TACI defect; CD19 defect; BAFFR defect
GWAS		Femur bone mineral density x serum urate levels interaction ( 34046847)	Alopecia areata ( 20596022 25608926) Aluminium levels ( 26025379) Body mass index ( 28892062) Celiac disease ( 20190752) Diastolic blood pressure ( 30224653) Hypothyroidism ( 27182965) Idiopathic dilated cardiomyopathy ( 29495422) Inflammatory bowel disease ( 26192919) Metabolite levels ( 23823483) Obesity-related traits ( 23251661) Primary biliary cholangitis ( 28425483) Rheumatoid arthritis ( 23143596) Rheumatoid arthritis (ACPA-positive) ( 23143596) Ulcerative colitis ( 26192919)
Interacting Genes		14 interacting genes: ICOS TNF TNFRSF4 UBE2A UBE2B UBE2D2 UBE2F UBE2G1 UBE2G2 UBE2L3 UBE2N UBE2V1 UBE2V2 UCP3	4 interacting genes: ICOSLG NUFIP2 RC3H1 WIF1
Entrez ID		149041	29851
HPRD ID		13913	09196
Ensembl ID		ENSG00000135870	ENSG00000163600
Uniprot IDs		B7ZMB3 B9EGU6 Q5TC82	Q53QY6 Q9Y6W8
PDB IDs		3X1O 4QIK 4QIL 4ULW 4YWQ 8RHS	6X4G 7JOO
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Postreplication Repair Protein Ubiquitination Ubiquitin-protein Transferase Activity UBC13-MMS2 Complex Ubiquitin-like Protein Transferase Activity Ubiquitin Conjugating Enzyme Complex Protein K63-linked Ubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Protein K48-linked Ubiquitination Positive Regulation Of Protein K63-linked Ubiquitination Protein Modification Process Regulation Of Protein K63-linked Ubiquitination Positive Regulation Of Protein Polyubiquitination Macromolecule Catabolic Process Error-free Postreplication DNA Repair Proteolysis Regulation Of Post-translational Protein Modification Proteasomal Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Regulation Of Protein Polyubiquitination Ubiquitin Protein Ligase Binding Positive Regulation Of Post-translational Protein Modification ATP Binding Protein K11-linked Ubiquitination Protein Catabolic Process Regulation Of Protein Modification Process HULC Complex Positive Regulation Of Protein Modification Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Metabolic Process Regulation Of Protein Ubiquitination Nucleotide Binding Transferase Activity DNA Damage Response Response To Stress Ubiquitin-protein Transferase Activator Activity Regulation Of DNA Metabolic Process DNA Repair Catabolic Process Positive Regulation Of DNA Metabolic Process Ubiquitin Ligase Complex Cellular Response To Stress Macromolecule Metabolic Process Response To Glucocorticoid	T Follicular Helper Cell Differentiation T Cell Differentiation Involved In Immune Response Regulation Of Activated T Cell Proliferation T-helper Cell Differentiation CD4-positive, Alpha-beta T Cell Differentiation Sperm DNA Decondensation Alpha-beta T Cell Differentiation CD4-positive, Alpha-beta T Cell Activation T Cell Activation Involved In Immune Response Zonula Adherens Assembly Cytoplasmic Stress Granule CCR4-NOT Complex Binding Negative Regulation Of Germinal Center Formation Alpha-beta T Cell Activation T Cell Receptor Signaling Pathway
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