SHOX and IGBP1

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		SHOX	IGBP1
Name		SHOX homeobox	immunoglobulin binding protein 1
Structure		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm	Cytoplasm Cytosol
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	Protein Binding Protein Phosphatase Regulator Activity Protein Phosphatase 2A Binding
	Biological Process	Skeletal System Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II	Negative Regulation Of Transcription By RNA Polymerase II Signal Transduction Regulation Of Signal Transduction Negative Regulation Of Stress-activated MAPK Cascade Response To Tumor Necrosis Factor Regulation Of Dephosphorylation Intracellular Signal Transduction B Cell Activation Regulation Of Microtubule-based Movement Response To Interleukin-1
Diseases		SHOX-related haploinsufficiency disorders, including: Isolated short stature; Langer syndrome; Leri-Weill syndrome	Corpus callosum, agenesis of, with mental retardation, ocular coloboma and micrognathia
GWAS		No GWAS studies recorded	No GWAS studies recorded
Interacting Genes		5 interacting genes: CSNK2A1 GLIS2 HEMK1 IGBP1 NKX2-5	12 interacting genes: APP HSPB1 LINC01257 MID1 MID2 PPP2CA PPP4C PPP6C PYGM REXO5 S100A13 SHOX
Entrez ID		6473	3476
HPRD ID		02430	02140
Ensembl ID		ENSG00000185960	ENSG00000089289
Uniprot IDs		O15266	P78318
PDB IDs		Not available	4IYP
GO Terms Enriched among Interactors		Negative Regulation Of Signal Transduction Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cell Communication Negative Regulation Of Signaling Septum Secundum Development Nkx-2.5 Complex Purkinje Myocyte Differentiation Protein-glutamine N-methyltransferase Activity Peptide Chain Release Factor N(5)-glutamine Methyltransferase Activity Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body His-Purkinje System Cell Differentiation Pulmonary Myocardium Development Atrial Cardiac Muscle Cell Development Atrioventricular Node Cell Fate Commitment Proepicardium Development Ventricular Cardiac Myofibril Assembly Right Ventricular Cardiac Muscle Tissue Morphogenesis Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cardioblast Differentiation Atrioventricular Node Cell Development Bundle Of His Development N-methyltransferase Activity Positive Regulation Of Aggrephagy Negative Regulation Of Biosynthetic Process Embryonic Heart Tube Left/right Pattern Formation Negative Regulation Of Transcription By RNA Polymerase II Apoptotic Process Involved In Heart Morphogenesis Atrioventricular Node Development Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process Transcription Cis-regulatory Region Binding Cardiac Muscle Cell Fate Commitment Cardiac Ventricle Formation Membraneless Organelle Assembly Atrial Septum Development Negative Regulation Of Stress-activated MAPK Cascade Negative Regulation Of Metabolic Process Ventricular Cardiac Muscle Cell Development Negative Regulation Of Stress-activated Protein Kinase Signaling Cascade Aggrephagy Double-strand Break Repair Via Classical Nonhomologous End Joining Regulation Of Wnt Signaling Pathway Protein Targeting To Vacuole Involved In Autophagy Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Muscle Cell Fate Commitment Negative Regulation Of DNA-templated Transcription Adult Heart Development Heart Trabecula Formation Ventricular Trabecula Myocardium Morphogenesis	Positive Regulation Of Interleukin-1 Production RAGE Receptor Binding Protein Serine/threonine Phosphatase Activity Protein Localization To Microtubule Response To Lead Ion Regulation Of Interleukin-1 Production Protein Homodimerization Activity Phosphoprotein Phosphatase Activity Regulation Of Intracellular Signal Transduction Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of Glycolytic Process Amylin Binding Positive Regulation Of Toll Signaling Pathway Negative Regulation Of Protein Kinase C Signaling Protein Localization To Cytoskeleton Phosphoprotein Binding RNA Polymerase II CTD Heptapeptide Repeat S7 Phosphatase Activity RNA Polymerase II CTD Heptapeptide Repeat S2 Phosphatase Activity Positive Regulation Of Interleukin-1 Beta Production Regulation Of Carbohydrate Catabolic Process Acetylcholine Receptor Activator Activity PTB Domain Binding Regulation Of ATP Metabolic Process Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Axo-dendritic Transport Regulation Of Signal Transduction Regulation Of Purine Nucleotide Metabolic Process Endosome To Plasma Membrane Transport Vesicle Regulation Of Supramolecular Fiber Organization Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Extracellular Exosome Regulation Of Interleukin-1 Beta Production Protein Kinase C Inhibitor Activity Regulation Of Canonical NF-kappaB Signal Transduction Cytoskeleton Protein Dephosphorylation RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity Glycogen Phosphorylase Activity Regulation Of Microtubule Polymerization Or Depolymerization Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway