SHOX and HEMK1

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		SHOX	HEMK1
Name		SHOX homeobox	HemK methyltransferase 1, mitochondrial release factors N(5)-glutamine
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm	Mitochondrion
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	Nucleic Acid Binding DNA Binding Protein Binding Methyltransferase Activity N-methyltransferase Activity Protein Methyltransferase Activity S-adenosylmethionine-dependent Methyltransferase Activity Transferase Activity Protein-glutamine N-methyltransferase Activity Peptide Chain Release Factor N(5)-glutamine Methyltransferase Activity
	Biological Process	Skeletal System Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II	Translational Termination Methylation
Diseases		SHOX-related haploinsufficiency disorders, including: Isolated short stature; Langer syndrome; Leri-Weill syndrome	None
GWAS		No GWAS studies recorded	Appendicular lean mass ( 33097823 ) Cholangiocarcinoma in primary sclerosing cholangitis (time to event) ( 28779025 ) Cocaine dependence ( 31212010 ) Depressive symptom (appetite changes) (binary trait) ( 31530331 ) Depressive symptoms (binary sum-score) ( 31530331 ) Depressive symptoms (sum-score) ( 31530331 ) Height ( 28552196 )
Interacting Genes		5 interacting genes: CSNK2A1 GLIS2 HEMK1 IGBP1 NKX2-5	18 interacting genes: AKAP8L ASCL3 CDC23 CHN1 CTAG1A CTAG1B HEATR9 INCA1 KRTAP19-1 MAGED1 PEF1 POU2AF1 PSMB4 SHOX SOHLH1 SPRYD7 TUBGCP5 UBQLN2
Entrez ID		6473	51409
HPRD ID		02430	13645
Ensembl ID		ENSG00000185960	ENSG00000114735
Uniprot IDs		O15266	A0A140VK98 B2RA37 Q9Y5R4
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Negative Regulation Of Signal Transduction Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cell Communication Negative Regulation Of Signaling Septum Secundum Development Nkx-2.5 Complex Purkinje Myocyte Differentiation Protein-glutamine N-methyltransferase Activity Peptide Chain Release Factor N(5)-glutamine Methyltransferase Activity Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body His-Purkinje System Cell Differentiation Pulmonary Myocardium Development Atrial Cardiac Muscle Cell Development Atrioventricular Node Cell Fate Commitment Proepicardium Development Ventricular Cardiac Myofibril Assembly Right Ventricular Cardiac Muscle Tissue Morphogenesis Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cardioblast Differentiation Atrioventricular Node Cell Development Bundle Of His Development N-methyltransferase Activity Positive Regulation Of Aggrephagy Negative Regulation Of Biosynthetic Process Embryonic Heart Tube Left/right Pattern Formation Negative Regulation Of Transcription By RNA Polymerase II Apoptotic Process Involved In Heart Morphogenesis Atrioventricular Node Development Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process Transcription Cis-regulatory Region Binding Cardiac Muscle Cell Fate Commitment Cardiac Ventricle Formation Membraneless Organelle Assembly Atrial Septum Development Negative Regulation Of Stress-activated MAPK Cascade Negative Regulation Of Metabolic Process Ventricular Cardiac Muscle Cell Development Negative Regulation Of Stress-activated Protein Kinase Signaling Cascade Aggrephagy Double-strand Break Repair Via Classical Nonhomologous End Joining Regulation Of Wnt Signaling Pathway Protein Targeting To Vacuole Involved In Autophagy Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Muscle Cell Fate Commitment Negative Regulation Of DNA-templated Transcription Adult Heart Development Heart Trabecula Formation Ventricular Trabecula Myocardium Morphogenesis	None