CAMTA2 and CALM3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CAMTA2	CALM3
Description		calmodulin binding transcription activator 2	calmodulin 3
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Spindle Pole Nucleus Cytoplasm Mitochondrion Centrosome Spindle Cytoskeleton Spindle Microtubule Plasma Membrane Voltage-gated Potassium Channel Complex Membrane Sarcomere Growth Cone Synaptic Vesicle Membrane Mitochondrial Membrane Vesicle Protein-containing Complex Calcium Channel Complex Myelin Sheath Calyx Of Held Sperm Midpiece Schaffer Collateral - CA1 Synapse Presynaptic Cytosol Postsynaptic Cytosol Catalytic Complex
	Molecular Function	DNA Binding Chromatin Binding Double-stranded DNA Binding Transcription Coregulator Activity Transcription Coactivator Activity Protein Binding Histone Deacetylase Binding Sequence-specific DNA Binding	Calcium Channel Regulator Activity Calcium Ion Binding Protein Binding Adenylate Cyclase Binding Adenylate Cyclase Activator Activity Protein Kinase Binding Protein Domain Specific Binding Nitric-oxide Synthase Regulator Activity Titin Binding Type 3 Metabotropic Glutamate Receptor Binding Protein Serine/threonine Kinase Activator Activity Phosphatidylinositol 3-kinase Binding Transmembrane Transporter Binding Metal Ion Binding Calcium-dependent Protein Binding Nitric-oxide Synthase Binding Protein Phosphatase Activator Activity Transporter Inhibitor Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II Cardiac Muscle Hypertrophy In Response To Stress Positive Regulation Of Transcription By RNA Polymerase II	G2/M Transition Of Mitotic Cell Cycle Response To Amphetamine Regulation Of Heart Rate Detection Of Calcium Ion G Protein-coupled Receptor Signaling Pathway Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Substantia Nigra Development Regulation Of Cytokinesis Regulation Of Calcium-mediated Signaling Response To Corticosterone Response To Calcium Ion Regulation Of Cardiac Muscle Contraction Long-term Synaptic Potentiation Establishment Of Protein Localization To Membrane Establishment Of Protein Localization To Mitochondrial Membrane Calcineurin-mediated Signaling Regulation Of Cardiac Muscle Cell Action Potential Presynaptic Endocytosis Regulation Of Synaptic Vesicle Endocytosis Negative Regulation Of High Voltage-gated Calcium Channel Activity Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Negative Regulation Of Calcium Ion Export Across Plasma Membrane Regulation Of Synaptic Vesicle Exocytosis
Pathways			CaMK IV-mediated phosphorylation of CREB CaMK IV-mediated phosphorylation of CREB Calmodulin induced events Cam-PDE 1 activation CaM pathway Platelet degranulation Translocation of SLC2A4 (GLUT4) to the plasma membrane Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation PKA activation DARPP-32 events Synthesis of IP3 and IP4 in the cytosol Calcineurin activates NFAT Calcineurin activates NFAT eNOS activation Transcriptional activation of mitochondrial biogenesis Inactivation, recovery and regulation of the phototransduction cascade Inactivation, recovery and regulation of the phototransduction cascade Stimuli-sensing channels FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization Ca2+ pathway Reduction of cytosolic Ca++ levels Sodium/Calcium exchangers Unblocking of NMDA receptors, glutamate binding and activation CREB1 phosphorylation through the activation of Adenylate Cyclase CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde Ras activation upon Ca2+ influx through NMDA receptor Smooth Muscle Contraction Smooth Muscle Contraction Activation of Ca-permeable Kainate Receptor Uptake and function of anthrax toxins VEGFR2 mediated vascular permeability VEGFR2 mediated cell proliferation Phase 0 - rapid depolarisation Ion homeostasis CLEC7A (Dectin-1) induces NFAT activation CLEC7A (Dectin-1) induces NFAT activation RHO GTPases activate IQGAPs RHO GTPases activate PAKs RHO GTPases activate PAKs RAF activation RAF/MAP kinase cascade Signaling by moderate kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Glycogen breakdown (glycogenolysis) Glycogen breakdown (glycogenolysis) Protein methylation Extra-nuclear estrogen signaling Loss of phosphorylation of MECP2 at T308 Regulation of MECP2 expression and activity Ion transport by P-type ATPases Negative regulation of NMDA receptor-mediated neuronal transmission Activation of RAC1 downstream of NMDARs Activation of RAC1 downstream of NMDARs Activation of AMPK downstream of NMDARs Long-term potentiation Long-term potentiation RAS processing Signaling downstream of RAS mutants Signaling by RAF1 mutants FCGR3A-mediated IL10 synthesis FCGR3A-mediated IL10 synthesis Antigen activates B Cell Receptor (BCR) leading to generation of second messengers High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells CASP4 inflammasome assembly Microbial factors inhibit CASP4 activity CASP4 inflammasome assembly Microbial factors inhibit CASP4 activity CASP4 inflammasome assembly Microbial factors inhibit CASP4 activity
Drugs			Chlorpromazine Cinchocaine Nicardipine Fluphenazine Isoflurane Trifluoperazine Loperamide Perphenazine Phenoxybenzamine Felodipine Melatonin Promethazine Pimozide Nifedipine Bepridil Calcium Aprindine Deacetoxyvinzolidine tert-butanol Trimethyllysine Dequalinium N-(6-Aminohexyl)-5-Chloro-1-Naphthalenesulfonamide Prenylamine Flunarizine (3Z)-N,N-DIMETHYL-2-OXO-3-(4,5,6,7-TETRAHYDRO-1H-INDOL-2-YLMETHYLIDENE)-2,3-DIHYDRO-1H-INDOLE-5-SULFONAMIDE Myristic acid Calcium citrate Calcium citrate Calcium citrate Calcium Phosphate Calcium Phosphate Calcium Phosphate Calcium levulinate Calcium phosphate dihydrate Calcium phosphate dihydrate Calcium phosphate dihydrate
Diseases
GWAS		Intraocular pressure ( 29617998) Keratoconus ( 33649486)	Crohn's disease ( 28067908) Immature fraction of reticulocytes ( 32888494) Ulcerative colitis ( 23128233)
Interacting Genes		8 interacting genes: CALM1 CALM2 CALM3 HDAC5 MAGEA6 MEMO1 NKX2-5 ZNF483	49 interacting genes: AKAP9 APPBP2 ASCL2 C11orf65 C5AR2 CACNA1A CALD1 CAMTA2 CCND2 CCP110 CHRM3 CLEC7A DDIT4L DRC9 DRD2 EDF1 EGFR ESR1 ESR2 GRM5 GRM7 GSC2 INSR IQCE IQCN IQSEC2 KCNN1 KCNQ2 KCNQ3 KCNQ5 MINK1 MYF5 MYF6 MYOD1 MYOG NEUROD1 NSMF PLCB3 POC5 PPEF1 PPEF2 RAB3B SDCBP SPATA17 TBC1D1 TCF3 TCF4 TRIM54 ZNF280A
Entrez ID		23125	808
HPRD ID		13002	00243
Ensembl ID		ENSG00000108509	ENSG00000160014
Uniprot IDs		I3L3W6 O94983	B4DJ51 P0DP23 P0DP24 P0DP25 Q96HY3 Q9BRL5
PDB IDs			1CDL 1CLL 1CTR 1IWQ 1J7O 1J7P 1K90 1K93 1L7Z 1LVC 1NKF 1PK0 1S26 1SK6 1SW8 1UP5 1WRZ 1XFU 1XFV 1XFW 1XFX 1XFY 1XFZ 1Y6W 1YR5 1YRT 1YRU 1ZOT 1ZUZ 2BE6 2F3Y 2F3Z 2HF5 2I08 2JZI 2K0E 2K0F 2K0J 2K61 2KNE 2KUG 2KUH 2L53 2L7L 2LGF 2LL6 2LL7 2LQC 2LQP 2LV6 2M0J 2M0K 2M55 2MG5 2N27 2N6A 2N77 2N8J 2R28 2V01 2V02 2VAY 2W73 2WEL 2X0G 2Y4V 3BYA 3DVE 3DVJ 3DVK 3DVM 3EVV 3EWT 3EWV 3G43 3HR4 3J41 3O77 3O78 3OXQ 3SUI 3UCT 3UCW 3UCY 4BW7 4BW8 4BYF 4DCK 4DJC 4GOW 4JPZ 4JQ0 4L79 4LZX 4M1L 4OVN 4Q57 4Q5U 4UMO 4UPU 4V0C 5COC 5DBR 5DOW 5DSU 5GGM 5I0I 5J03 5J8H 5JQA 5JTH 5K7L 5K8Q 5NIN 5OEO 5TP5 5TP6 5V02 5V03 5V7X 5VMS 5WBX 5WC5 5WSU 5WSV 6B8L 6B8M 6B8N 6B8P 6B8Q 6BUT 6C1D 6C1G 6C1H 6CNM 6CNN 6CNO 6DAD 6DAE 6DAF 6DAH 6E2F 6E2G 6EEB 6FEG 6FEH 6GDK 6GDL 6HCS 6HR1 6JI8 6JII 6JIU 6JIY 6JRS 6JV2 6K4K 6K4L 6K4R 6K67 6M2W 6M7H 6MUD 6MUE 6N5W 6O5G 6OS4 6PAW 6PBX 6PBY 6PLM 6S5T 6SZ5 6TV7 6U39 6U3A 6U3B 6U3D 6UZZ 6V00 6V01 6X32 6X33 6X35 6X36 6XXF 6XXX 6XY3 6XYR 6Y4O 6Y4P 6Y94 6Y95 6YA9 6YNS 6YNU 6ZBI 7AUG 7BF1 7BF2 7BYL 7BYM 7BYN 7CR3 7CR4 7CR7 7KL5 7L8V 7MIR 7MIS 7PPO 7PQE 7PSZ 7PU9 7SHQ 7SX3 7SX4 7T2Q 7TCI 7TCP 7TZC 7U9T 7UA3 7UA4 7VMB 7VNP 7VNQ 7VNR 7VUO 7VUR 7VUS 7VUT 7VUU 7VVD 7VVH 7WJI 7WR3 7WR4 7WR5 7WZS 7XN4 7XN5 7XN6 7XNI 7XNK 7XNL 7XNN 7ZRP 7ZRQ 8AHS 8B6Q 8BD2 8BFG 8DGH 8DGK 8DUJ 8DVE 8EOW 8EP0 8EP1 8FNY 8FO6 8GM4 8GM5 8IJK 8J00 8J01 8J02 8J03 8J04 8J05 8J07 8JFK 8K9Z 8KA0 8KA1 8ODZ 8OE0 8OE4 8PB1 8SIK 8SIM 8SIN 8UXL 8UXM 8W4U 8X43 8XJI 8XKH 8XLF 8XLH 8XO1 8XYA 8XYB 8Y40 9CUI 9CUK 9E17 9JQI 9K8W 9K8X
Enriched GO Terms of Interacting Partners?		Transporter Inhibitor Activity Negative Regulation Of Calcium Ion Export Across Plasma Membrane Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Titin Binding Detection Of Calcium Ion Regulation Of Cardiac Muscle Contraction Regulation Of Cell Communication By Electrical Coupling Protein Phosphatase Activator Activity Calyx Of Held Regulation Of Striated Muscle Contraction Catalytic Complex Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Negative Regulation Of Transporter Activity Negative Regulation Of High Voltage-gated Calcium Channel Activity Calcium Channel Complex Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Calcineurin-mediated Signaling Presynaptic Cytosol Myelin Sheath Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Negative Regulation Of Calcium Ion Transmembrane Transport Regulation Of Muscle Contraction Spindle Microtubule Presynaptic Endocytosis Substantia Nigra Development Calcium Channel Regulator Activity Regulation Of Heart Contraction Sperm Midpiece Negative Regulation Of Calcium Ion Transport G2/M Transition Of Mitotic Cell Cycle Long-term Synaptic Potentiation Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Sarcomere Cell Cycle G2/M Phase Transition Neural Nucleus Development Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Muscle System Process Regulation Of Blood Circulation Negative Regulation Of Cation Transmembrane Transport Protein Serine/threonine Kinase Activator Activity Positive Regulation Of Sequestering Of Calcium Ion Negative Regulation Of Monoatomic Ion Transmembrane Transport Voltage-gated Potassium Channel Complex Negative Regulation Of Voltage-gated Calcium Channel Activity Calcium-dependent Protein Binding Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Monoatomic Ion Transmembrane Transporter Activity	E-box Binding Chemical Synaptic Transmission Protein Dimerization Activity Trans-synaptic Signaling Synaptic Signaling Calmodulin Binding Positive Regulation Of Skeletal Muscle Fiber Development Regulation Of Skeletal Muscle Fiber Development Cellular Response To Estradiol Stimulus Muscle Cell Fate Commitment Cell-cell Signaling Signaling Positive Regulation Of Skeletal Muscle Tissue Development Cell Communication Positive Regulation Of Striated Muscle Tissue Development Regulation Of Skeletal Muscle Tissue Development Response To Estradiol Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Voltage-gated Potassium Channel Complex DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Sequence-specific DNA Binding Regulation Of Striated Muscle Tissue Development Chromatin Positive Regulation Of Striated Muscle Cell Differentiation Regulation Of Muscle Organ Development Regulation Of Myotube Differentiation Positive Regulation Of Myoblast Differentiation Cell Fate Commitment RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity Positive Regulation Of Dopamine Uptake Involved In Synaptic Transmission Euchromatin Cellular Response To Oxygen-containing Compound Positive Regulation Of Cell Differentiation Skeletal Muscle Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Transcription Regulator Complex DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Skeletal Muscle Tissue Development Nuclear Estrogen Receptor Activity TFIIB-class Transcription Factor Binding Regulation Of Synaptic Transmission, Glutamatergic Positive Regulation Of Developmental Process Positive Regulation Of Muscle Cell Differentiation BHLH Transcription Factor Binding Regulation Of Developmental Process Regulation Of Myoblast Differentiation Positive Regulation Of RNA Metabolic Process
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