ZNF420 and TNFRSF1B

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		ZNF420	TNFRSF1B
Description		zinc finger protein 420	TNF receptor superfamily member 1B
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm	Tumor Necrosis Factor Receptor Superfamily Complex Extracellular Region Plasma Membrane Membrane Specific Granule Membrane Membrane Raft
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding	Tumor Necrosis Factor Receptor Activity Protein Binding Ubiquitin Protein Ligase Binding Tumor Necrosis Factor Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II	Regulation Of Cytokine Production Involved In Immune Response Regulation Of T Cell Cytokine Production Aortic Valve Development Pulmonary Valve Development Negative Regulation Of Extracellular Matrix Constituent Secretion Apoptotic Process Inflammatory Response Cell Surface Receptor Signaling Pathway Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Cardiac Muscle Hypertrophy Regulation Of Myelination Positive Regulation Of Myelination Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of T Cell Proliferation Positive Regulation Of Oligodendrocyte Differentiation Negative Regulation Of Inflammatory Response RNA Destabilization Positive Regulation Of Membrane Protein Ectodomain Proteolysis Cellular Response To Lipopolysaccharide Extrinsic Apoptotic Signaling Pathway Regulation Of Neuroinflammatory Response Negative Regulation Of Neuroinflammatory Response Glial Cell-neuron Signaling Positive Regulation Of Apoptotic Process Involved In Morphogenesis
Pathways		Generic Transcription Pathway TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	TNFR2 non-canonical NF-kB pathway TNFs bind their physiological receptors Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Neutrophil degranulation
Drugs			Tasonermin
Diseases			Graft-versus-host disease
GWAS		A body shape index ( 34021172) Appendicular lean mass ( 33097823) Eosinophil percentage of white cells ( 32888494) Hip circumference adjusted for BMI ( 34021172) Plateletcrit ( 32888494) Prudent dietary pattern ( 28644415) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Asthma ( 31959851) Blood protein levels ( 30072576) Blood protein levels in cardiovascular risk ( 28369058) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Tuberculosis ( 29036319) Urate levels (BMI interaction) ( 25811787)
Interacting Genes		15 interacting genes: AIRIM CDC42 CDK2AP1 CDKN2A CEP19 CYP4V2 CYP51A1 EXOSC5 HAX1 KRTAP10-7 MDM2 SLC1A7 TNFRSF1B TRIM28 ZNF76	21 interacting genes: BMX CAV1 CD14 CSNK1A1 CSNK1A1L FANCD2 FOXP1 HIVEP3 KRT18 LTA PKN1 STAT1 TDP2 TNF TRAF1 TRAF2 TRAF3 TRAIP TRIM37 UBQLN1 ZNF420
Entrez ID		147923	7133
HPRD ID		08122	01862
Ensembl ID		ENSG00000197050	ENSG00000028137
Uniprot IDs		Q8TAQ5	P20333
PDB IDs			1CA9 3ALQ 8HLB 9CU8
Enriched GO Terms of Interacting Partners?		SUMO Transferase Activity Positive Regulation Of Apoptotic Process Involved In Development Positive Regulation Of Apoptotic Process Involved In Morphogenesis Protein Sumoylation Regulation Of Establishment Of Protein Localization Regulation Of Nucleocytoplasmic Transport Heart Valve Development Disordered Domain Specific Binding Regulation Of Intracellular Protein Transport Amyloid Fibril Formation Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Protein Export From Nucleus Regulation Of Protein Transport Regulation Of Protein Targeting To Mitochondrion Regulation Of Protein Localization Ligase Inhibitor Activity Sterol 14-demethylase Activity Cholesterol Biosynthetic Process Via 24,25-dihydrolanosterol Response To Formaldehyde Cellular Response To Vitamin B1 Vesicle Targeting, Trans-Golgi To Periciliary Membrane Compartment Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Protein Destabilization Euchromatin Regulation Of Transport GBD Domain Binding Storage Vacuole P53 Binding Cellular Response To Hydrogen Peroxide Regulation Of Intracellular Transport Monooxygenase Activity Positive Regulation Of Nucleocytoplasmic Transport Extracellularly Glutamate-gated Chloride Channel Activity Krueppel-associated Box Domain Binding	Tumor Necrosis Factor Receptor Binding Tumor Necrosis Factor-mediated Signaling Pathway Cell Death Programmed Cell Death Regulation Of Immune Response Apoptotic Process Regulation Of Immune System Process Regulation Of Canonical NF-kappaB Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Signal Transduction Thioesterase Binding Regulation Of Defense Response Cytokine-mediated Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Immune Response Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Chronic Inflammatory Response To Antigenic Stimulus Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Cytokine Production Signal Transduction Regulation Of Apoptotic Process Regulation Of Cytokine Production Regulation Of Programmed Cell Death Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Chronic Inflammatory Response Aggresome Regulation Of Intracellular Signal Transduction Regulation Of Macromolecule Metabolic Process Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Immune System Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Type I Interferon Production Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Response To Stress Cell Surface Toll-like Receptor Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Cell Surface Pattern Recognition Receptor Signaling Pathway Negative Regulation Of Endothelial Cell Proliferation Pattern Recognition Receptor Signaling Pathway Regulation Of Chronic Inflammatory Response Regulation Of Metabolic Process Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Metabolic Process Immune Response-activating Signaling Pathway Innate Immune Response-activating Signaling Pathway Regulation Of Gene Expression Regulation Of Nitric Oxide Metabolic Process Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Gene Expression
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