ZNF420 and SLC1A7

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		ZNF420	SLC1A7
Description		zinc finger protein 420	solute carrier family 1 member 7
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm	Plasma Membrane Membrane Synapse Synaptic Membrane Postsynapse
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding	L-glutamate Transmembrane Transporter Activity High-affinity L-glutamate Transmembrane Transporter Activity Extracellularly Glutamate-gated Chloride Channel Activity Neutral L-amino Acid Transmembrane Transporter Activity Symporter Activity Glutamate:sodium Symporter Activity
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II	Neurotransmitter Uptake Monoatomic Ion Transport Dicarboxylic Acid Transport Neurotransmitter Transport Neutral Amino Acid Transport L-glutamate Transmembrane Transport Excitatory Postsynaptic Potential Import Into Cell Chloride Transmembrane Transport
Pathways		Generic Transcription Pathway TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	Glutamate Neurotransmitter Release Cycle SLC-mediated transport of amino acids
Drugs			Glutamic acid
Diseases
GWAS		A body shape index ( 34021172) Appendicular lean mass ( 33097823) Eosinophil percentage of white cells ( 32888494) Hip circumference adjusted for BMI ( 34021172) Plateletcrit ( 32888494) Prudent dietary pattern ( 28644415) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Hippocampal atrophy ( 22745009) Systemic lupus erythematosus ( 21408207)
Interacting Genes		15 interacting genes: AIRIM CDC42 CDK2AP1 CDKN2A CEP19 CYP4V2 CYP51A1 EXOSC5 HAX1 KRTAP10-7 MDM2 SLC1A7 TNFRSF1B TRIM28 ZNF76	2 interacting genes: SNTA1 ZNF420
Entrez ID		147923	6512
HPRD ID		08122	09194
Ensembl ID		ENSG00000197050	ENSG00000162383
Uniprot IDs		Q8TAQ5	A0A087WUF9 F1T0D3 F1T0D4 G1CT06 O00341
PDB IDs
Enriched GO Terms of Interacting Partners?		SUMO Transferase Activity Positive Regulation Of Apoptotic Process Involved In Development Positive Regulation Of Apoptotic Process Involved In Morphogenesis Protein Sumoylation Regulation Of Establishment Of Protein Localization Regulation Of Nucleocytoplasmic Transport Heart Valve Development Disordered Domain Specific Binding Regulation Of Intracellular Protein Transport Amyloid Fibril Formation Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Protein Export From Nucleus Regulation Of Protein Transport Regulation Of Protein Targeting To Mitochondrion Regulation Of Protein Localization Ligase Inhibitor Activity Sterol 14-demethylase Activity Cholesterol Biosynthetic Process Via 24,25-dihydrolanosterol Response To Formaldehyde Cellular Response To Vitamin B1 Vesicle Targeting, Trans-Golgi To Periciliary Membrane Compartment Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Protein Destabilization Euchromatin Regulation Of Transport GBD Domain Binding Storage Vacuole P53 Binding Cellular Response To Hydrogen Peroxide Regulation Of Intracellular Transport Monooxygenase Activity Positive Regulation Of Nucleocytoplasmic Transport Extracellularly Glutamate-gated Chloride Channel Activity Krueppel-associated Box Domain Binding	Cardiac Muscle Cell Action Potential Involved In Contraction Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Cardiac Muscle Cell Action Potential Regulation Of Sodium Ion Transmembrane Transport Sodium Channel Regulator Activity Dystrophin-associated Glycoprotein Complex Syntrophin Complex Ventricular Cardiac Muscle Cell Action Potential Nitric-oxide Synthase Binding Regulation Of Membrane Repolarization Neuromuscular Junction ATPase Binding Lateral Plasma Membrane PDZ Domain Binding Regulation Of Sodium Ion Transport Sarcolemma Regulation Of Heart Rate Action Potential
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