NFATC3 and TTF1

Number of citations of the paper that reports this interaction (PubMedID 15173172)
0

Data Source:
HPRD (in vivo)

		NFATC3	TTF1
Description		nuclear factor of activated T cells 3	transcription termination factor 1
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Cytosol	Fibrillar Center Nucleus Nucleoplasm Nucleolus
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding	DNA Binding Chromatin Binding Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Inflammatory Response Calcineurin-NFAT Signaling Cascade Positive Thymic T Cell Selection Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of MiRNA Transcription DN4 Thymocyte Differentiation Negative Regulation Of Vascular Associated Smooth Muscle Cell Differentiation Positive Regulation Of Artery Morphogenesis	Chromatin Remodeling DNA-templated Transcription Termination Transcription By RNA Polymerase I Transcription Initiation At RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription Negative Regulation Of DNA Replication
Pathways		Calcineurin activates NFAT Calcineurin activates NFAT FCERI mediated Ca+2 mobilization CLEC7A (Dectin-1) induces NFAT activation	ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression Surfactant metabolism RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription Termination RNA Polymerase I Transcription Termination
Drugs
Diseases			Benign hereditary chorea
GWAS		Chronotype ( 30696823) Estimated glomerular filtration rate ( 31015462) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656) Serum alkaline phosphatase levels ( 33547301) Urate levels ( 31578528)
Interacting Genes		7 interacting genes: CDK6 CSNK1A1 FOS IGF2BP3 MAPK8 MAPK9 TTF1	6 interacting genes: BAZ2A CAVIN1 KAT2B NFATC3 SMAD1 SMAD7
Entrez ID		4775	7270
HPRD ID		04077	02866
Ensembl ID		ENSG00000072736	ENSG00000125482
Uniprot IDs		B5B2S0 B5B2S1 Q12968	A0A087WY09 Q15361
PDB IDs		2XRW 2XS0
Enriched GO Terms of Interacting Partners?		JUN Kinase Activity Parallel Fiber To Purkinje Cell Synapse Protein Serine Kinase Activity NLRP3 Inflammasome Complex Assembly Cellular Response To Reactive Oxygen Species Fc-epsilon Receptor Signaling Pathway MAP Kinase Activity Protein Serine/threonine Kinase Activity R-SMAD Binding Response To Reactive Oxygen Species Positive Regulation Of NLRP3 Inflammasome Complex Assembly Canonical Inflammasome Complex Assembly Protein Kinase Activity Positive Regulation Of Protein-containing Complex Assembly Regulation Of NLRP3 Inflammasome Complex Assembly Cellular Response To Oxidative Stress Regulation Of MRNA Stability Regulation Of RNA Stability Cyclin D2-CDK6 Complex Medium-term Memory Cellular Response To Prolactin JUN Phosphorylation Positive Regulation Of MiRNA Transcription Fc Receptor Signaling Pathway Cellular Response To Nutrient Levels JNK Cascade Kinase Activity Positive Regulation Of MiRNA Metabolic Process Cellular Response To Chemical Stress Cellular Senescence Dendriole Calcium Ion Binding Involved In Regulation Of Presynaptic Cytosolic Calcium Ion Concentration Cyclin D3-CDK6 Complex Cyclin D1-CDK6 Complex FBXO Family Protein Binding I(KACh) Inward Rectifier Potassium Channel Complex Protein Localization To Tricellular Tight Junction Phosphatidylinositol-4,5-bisphosphate Binding Regulation Of MiRNA Transcription Nucleus Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Gene Expression Neural Plate Anterior/posterior Regionalization Response To Prolactin Conditioned Taste Aversion Regulation Of MiRNA Metabolic Process Regulation Of MRNA Metabolic Process Termination Of RNA Polymerase I Transcription Regulation Of Cell Growth By Extracellular Stimulus Protein Phosphorylation	Heteromeric SMAD Protein Complex I-SMAD Binding SMAD Protein Signal Transduction Positive Regulation Of Cartilage Development Transcription Regulator Complex Ureteric Bud Development Mesonephric Epithelium Development Mesonephric Tubule Development Regulation Of Cartilage Development Negative Regulation Of Muscle Cell Differentiation Protein-containing Complex Kidney Epithelium Development Beta-catenin Destruction Complex Disassembly Positive Regulation Of Chondrocyte Hypertrophy Orexigenic Neuropeptide QRFP Receptor Binding Regulation Of MiRNA Transcription Homomeric SMAD Protein Complex Regulation Of MiRNA Metabolic Process Positive Regulation Of Chondrocyte Development DN4 Thymocyte Differentiation Negative Regulation Of RRNA Processing Histone H3K9 Acetyltransferase Activity NoRC Complex Cerebellar Purkinje Cell Layer Formation Paranodal Junction Maintenance DNA-templated Transcription Mesodermal Cell Fate Commitment Osteoblast Fate Commitment Transforming Growth Factor Beta Receptor Signaling Pathway Chromatin N-terminal Peptidyl-lysine Acetylation Diamine N-acetyltransferase Activity Stereocilia Ankle Link USH2 Complex Termination Of RNA Polymerase I Transcription RRNA Primary Transcript Binding Regulation Of Muscle Cell Differentiation Positive Regulation Of Neuron Projection Development Anti-Mullerian Hormone Receptor Signaling Pathway Activin Receptor Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of Chondrocyte Proliferation Negative Regulation Of RNA Biosynthetic Process Regulation Of Chondrocyte Development Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Regulation Of Ribosome Biogenesis L-lysine N-acetyltransferase Activity, Acting On Acetyl Phosphate As Donor Negative Regulation Of Ribosome Biogenesis Positive Regulation Of Transcription By Glucose Regulation Of Transcription From RNA Polymerase II Promoter By Glucose
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