NFATC3 and FOS

Number of citations of the paper that reports this interaction (PMID 9121455)
6

Data Source:
HPRD (in vivo, in vitro)

		NFATC3	FOS
Gene Name		nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3	FBJ murine osteosarcoma viral oncogene homolog
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Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol	Nucleus Nucleoplasm Transcription Factor Complex Endoplasmic Reticulum Cytosol Membrane Neuron Projection
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Chromatin Binding Protein Binding	RNA Polymerase II Core Promoter Sequence-specific DNA Binding Double-stranded DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding Transcription Regulatory Region DNA Binding R-SMAD Binding
	Biological Process	Patterning Of Blood Vessels Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Inflammatory Response Heart Development Fc-epsilon Receptor Signaling Pathway Innate Immune Response Cellular Respiration Positive Regulation Of Transcription From RNA Polymerase II Promoter Smooth Muscle Cell Differentiation Muscle Cell Development Cellular Response To Calcium Ion Cellular Response To Lithium Ion	Conditioned Taste Aversion Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway DNA Methylation Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Inflammatory Response Transforming Growth Factor Beta Receptor Signaling Pathway Nervous System Development Female Pregnancy Aging Response To Cold Response To Light Stimulus Response To Mechanical Stimulus Response To Gravity Response To Toxic Substance Sleep Cellular Response To Extracellular Stimulus Response To Lipopolysaccharide Response To Progesterone Cellular Response To Hormone Stimulus Response To Cytokine Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Cellular Response To Reactive Oxygen Species TRIF-dependent Toll-like Receptor Signaling Pathway Response To Immobilization Stress Skeletal Muscle Cell Differentiation Fc-epsilon Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Response To Drug Innate Immune Response Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Stress-activated MAPK Cascade Response To Corticosterone Response To CAMP SMAD Protein Signal Transduction Cellular Response To Calcium Ion
Pathways		Fc epsilon receptor (FCERI) signaling FCERI mediated Ca+2 mobilization Innate Immune System	Toll Like Receptor 7/8 (TLR7/8) Cascade Cellular Senescence FCERI mediated MAPK activation Toll Like Receptor TLR6:TLR2 Cascade Activated TLR4 signalling Toll Like Receptor TLR1:TLR2 Cascade Activation of the AP-1 family of transcription factors MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade MyD88 dependent cascade initiated on endosome TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88:Mal cascade initiated on plasma membrane Toll Like Receptor 9 (TLR9) Cascade Innate Immune System TRIF-mediated TLR3/TLR4 signaling MAP kinase activation in TLR cascade Senescence-Associated Secretory Phenotype (SASP) MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Oxidative Stress Induced Senescence Toll Like Receptor 3 (TLR3) Cascade Toll Like Receptor 4 (TLR4) Cascade Fc epsilon receptor (FCERI) signaling MAPK targets/ Nuclear events mediated by MAP kinases
Drugs			Nadroparin
Diseases
GWAS			Inflammatory bowel disease ( 23128233) Periodontal microbiota ( 22699663)
Protein-Protein Interactions		6 interactors: CDK6 CSNK1A1 FOS MAPK8 MAPK9 TTF1	108 interactors: ANP32E APP AQP1 ARFGAP1 ARL6IP4 ATF2 ATF3 ATF4 ATF7 ATP5I BATF BCL3 CABP1 CARM1 CEBPA CEBPE CEBPG CENPO CFAP57 CLU COPS4 CREB5 CREBBP CSNK2A1 CSNK2A2 CYTH4 DDIT3 EEF1D ELK1 ELK4 EPHB2 ETS1 ETS2 GAMT GATA4 GLB1 GNG11 GRHPR GTF2E2 GTF2F1 GTF2F2 HNF1A HSPA1A JUN JUNB JUND KDM2A LMNA LMO3 LUZP4 MAF MAFB MAFF MAP1B MAP3K7 MAPK1 MAPK7 MITF MTERF4 NACA NCOA1 NCOA2 NCOA3 NCOA6 NCOR2 NEFM NELFB NFATC3 NFKB1 OPTN PML POLR2E PRKAA2 PRKACA PSMC5 RB1 RELA RPS6KA1 RPS6KA2 RPS6KA4 RUNX1 RUNX2 SCHIP1 SET SIRT1 SMAD3 SMARCD1 SPI1 SRA1 STAT1 SUMO1 SUMO2 SUMO3 SUMO4 TAF1 TBP TRO TSC22D3 TSPAN2 UBE2D1 UBE2I UBE2L3 UBR1 USF1 USF2 VDR XBP1 ZNF133
Entrez ID		4775	2353
HPRD ID		04077	01275
Ensembl ID		ENSG00000072736	ENSG00000170345
Uniprot IDs		B5B2S0 B5B2S1 B5B2S3 B5B2S4 I3L3K7 Q12968	B4DQ65 P01100 Q6FG41
PDB IDs		2XRW 2XS0	1A02 1FOS 1S9K
Enriched GO Terms of Interacting Partners?		Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway JUN Phosphorylation Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Regulation Of Circadian Rhythm Toll-like Receptor Signaling Pathway Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Pattern Recognition Receptor Signaling Pathway Phosphate-containing Compound Metabolic Process Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Gene Expression Positive Regulation Of Innate Immune Response Response To Other Organism Response To Biotic Stimulus Response To Mechanical Stimulus Response To External Stimulus MAPK Cascade Fc-epsilon Receptor Signaling Pathway Phosphorylation Regulation Of Innate Immune Response Fc Receptor Signaling Pathway Signal Transduction By Phosphorylation Response To Lipopolysaccharide Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Response To Metal Ion Response To Molecule Of Bacterial Origin Response To Light Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway Response To Cadmium Ion Regulation Of Immune System Process Response To Radiation Protein Phosphorylation Hippocampus Development Immune Response-regulating Signaling Pathway Response To Inorganic Substance Regulation Of Cell Morphogenesis Response To Bacterium Signaling JNK Cascade Cell Communication	Transcription, DNA-templated RNA Biosynthetic Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Gene Expression Gene Expression RNA Metabolic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of RNA Metabolic Process Positive Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Nitrogen Compound Metabolic Process Cellular Metabolic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Regulation Of Cell Differentiation Negative Regulation Of Biosynthetic Process Response To Organic Substance Negative Regulation Of Gene Expression Regulation Of Cellular Process Cellular Response To Organic Substance Developmental Process System Development Viral Process Anatomical Structure Development Cell Differentiation Response To Stress Multicellular Organismal Development Response To External Stimulus Organ Development Negative Regulation Of Transcription From RNA Polymerase II Promoter TRIF-dependent Toll-like Receptor Signaling Pathway
Tagcloud ?		acting aortic basally cardiomyocyte cardiomyocytes complimentary concert constriction coupled desensitize exaggerated exert facilitator failing grk2 grk5 grks hypertrophic hypertrophy maladaptive myocardium myocytes nucleus participates phenylephrine rationale reside transverse	ap argue capable dimeric dimerization disrupt glucocorticoid heterodimerization homo homodimerization hraralpha hybrid indirect interfere jun liganded occurring promoters protooncoproteins ra raralpha rars repress repression responsive retinoic retinoid rxr rxrs
Tagcloud (Difference) ?		acting aortic basally cardiomyocyte cardiomyocytes complimentary concert constriction coupled desensitize exaggerated exert facilitator failing grk2 grk5 grks hypertrophic hypertrophy maladaptive myocardium myocytes nucleus participates phenylephrine rationale reside transverse	ap argue capable dimeric dimerization disrupt glucocorticoid heterodimerization homo homodimerization hraralpha hybrid indirect interfere jun liganded occurring promoters protooncoproteins ra raralpha rars repress repression responsive retinoic retinoid rxr rxrs
Tagcloud (Intersection) ?