CRYGD and CRYAB

Number of citations of the paper that reports this interaction (PMID 22655036)
6

Data Source:
BioGRID (pull down)

		CRYGD	CRYAB
Gene Name		crystallin, gamma D	crystallin, alpha B
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm	Nucleus Cytoplasm Mitochondrion Golgi Apparatus Cytosol Plasma Membrane Cell Surface Microtubule Cytoskeleton Z Disc Actin Filament Bundle Extracellular Vesicular Exosome
	Molecular Function	Structural Constituent Of Eye Lens Protein Binding	Structural Constituent Of Eye Lens Protein Binding Microtubule Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Unfolded Protein Binding
	Biological Process	Lens Development In Camera-type Eye Visual Perception Cellular Response To Reactive Oxygen Species Lens Fiber Cell Differentiation	Response To Hypoxia Lens Development In Camera-type Eye Protein Folding Muscle Contraction Tubulin Complex Assembly Muscle Organ Development Aging Regulation Of Cell Death Negative Regulation Of Cell Growth Microtubule Polymerization Or Depolymerization Response To Estradiol Negative Regulation Of Intracellular Transport Response To Hydrogen Peroxide Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Protein Homooligomerization Stress-activated MAPK Cascade Apoptotic Process Involved In Morphogenesis Cellular Response To Gamma Radiation Negative Regulation Of Reactive Oxygen Species Metabolic Process
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		3 interactors: CRYAA CRYAB CRYGC	44 interactors: ACOT7 APOC2 APP AVP B2M BAG3 BCL2L1 BMPR2 CASP3 CCL22 CCND1 CRYAA CRYBA1 CRYBB2 CRYGC CRYGD CS DDX20 DES EPB41 FCGR2A FGF2 GFAP HBA1 HSPB1 HSPB2 HSPB8 INS KRTAP19-5 KRTAP8-1 LALBA MDH2 MIP MRPL11 NGF PRKAG3 PSMA3 SNCA SOD1 TNPO2 TRAPPC6A TTN UBE2D1 VEGFA
Entrez ID		1421	1410
HPRD ID		00436	00428
Ensembl ID		ENSG00000118231	ENSG00000109846
Uniprot IDs		P07320	P02511
PDB IDs		1H4A 1HK0 1LD0 2G98 2KFB 2KLJ 4GR7 4JGF	2KLR 2WJ7 2Y1Y 2Y1Z 2Y22 2YGD 3L1G 3SGM 3SGN 3SGO 3SGP 3SGR 3SGS
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Intracellular Transport Visual Perception Sensory Perception Of Light Stimulus Protein Homooligomerization Camera-type Eye Development Negative Regulation Of Transport Eye Development Tubulin Complex Assembly Protein Oligomerization Regulation Of Intracellular Transport Sensory Organ Development Apoptotic Process Involved In Morphogenesis Cellular Response To Gamma Radiation Apoptotic Process Involved In Development Sensory Perception Negative Regulation Of Apoptotic Process Developmental Programmed Cell Death Negative Regulation Of Programmed Cell Death Microtubule Polymerization Or Depolymerization Negative Regulation Of Cell Death Negative Regulation Of Reactive Oxygen Species Metabolic Process Protein Complex Assembly Regulation Of Cellular Localization Response To Gamma Radiation Neurological System Process Cellular Response To Ionizing Radiation Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Regulation Of Apoptotic Process Lens Development In Camera-type Eye Regulation Of Cell Death Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Response To Estradiol Response To Hydrogen Peroxide	Response To Stress Negative Regulation Of Cell Death Positive Regulation Of Protein Metabolic Process Regulation Of Protein Phosphorylation Regulation Of Cell Death Response To External Stimulus Negative Regulation Of Apoptotic Process Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Programmed Cell Death Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Regulation Of Phosphorus Metabolic Process Regulation Of Phosphorylation Response To Abiotic Stimulus Positive Regulation Of Protein Modification Process Positive Regulation Of Endothelial Cell Chemotaxis Positive Regulation Of Transferase Activity Regulation Of Cellular Protein Metabolic Process Visual Perception Sensory Perception Of Light Stimulus Regulation Of Apoptotic Process Negative Regulation Of Catalytic Activity Regulation Of Lipid Metabolic Process Response To Stimulus Regulation Of Catalytic Activity Positive Regulation Of Catalytic Activity Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Cellular Response To Oxidative Stress Regulation Of Proteolysis Regulation Of Protein Metabolic Process Positive Regulation Of Cell Growth Positive Regulation Of Growth Response To Wounding Neuron Apoptotic Process Camera-type Eye Development Positive Regulation Of Protein Autophosphorylation Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Protein Phosphorylation Regulation Of Neuron Apoptotic Process Regulation Of Lipid Biosynthetic Process Organ Development Neuron Death Apoptotic Process Positive Regulation Of Blood Vessel Endothelial Cell Migration Eye Development Programmed Cell Death Sensory Organ Development Response To Oxidative Stress Platelet Degranulation Sensory Perception
Tagcloud ?		2j 6v2 beadchip bxd crosses cryab cryba1 crybb3 cryga crystallin crystallins dba extralenticular genenetwork genomatix hamilton hei hle hlec illumina immunoblots inbred maf mafa mousewg retina rgc ri sentrix	adaptive aggregated antiapoptotic assisting cardiomyocyte cardiomyocytes chaperons confers correct crystallin elicit emphasizing folding hsp hsps interplay lumen mini misfolded mitigate myocardium myocytes referred stressed stresses undergo unfolded upr worldwide
Tagcloud (Difference) ?		2j 6v2 beadchip bxd crosses cryba1 crybb3 cryga crystallins dba extralenticular genenetwork genomatix hamilton hei hle hlec illumina immunoblots inbred maf mafa mousewg retina rgc ri sentrix	adaptive aggregated antiapoptotic assisting cardiomyocyte cardiomyocytes chaperons confers correct elicit emphasizing folding hsp hsps interplay lumen mini misfolded mitigate myocardium myocytes referred stressed stresses undergo unfolded upr worldwide
Tagcloud (Intersection) ?		cryab crystallin