CRYGD and CRYAB

Number of citations: 68 (PubMedID 22655036)
Data Source: BioGRID (pull down)

		CRYGD	CRYAB
Name		crystallin gamma D	crystallin alpha B
Structure
GO Annotations	Cellular Component	Nucleus Cytoplasm	Extracellular Region Nucleus Nucleoplasm Cytoplasm Mitochondrion Lysosome Cytosol Plasma Membrane Cell Surface Z Disc Axon M Band I Band Actin Filament Bundle Protein-containing Complex Dendritic Spine Perikaryon Contractile Muscle Fiber Extracellular Exosome Synaptic Membrane Cardiac Myofibril
	Molecular Function	Structural Constituent Of Eye Lens Protein Binding	Amyloid-beta Binding Structural Molecule Activity Structural Constituent Of Eye Lens Protein Binding Microtubule Binding Cytoskeletal Protein Binding Identical Protein Binding Protein Homodimerization Activity Protein-containing Complex Binding Metal Ion Binding Unfolded Protein Binding
	Biological Process	Lens Development In Camera-type Eye Visual Perception Cellular Response To Reactive Oxygen Species Lens Fiber Cell Differentiation	Response To Hypoxia Lens Development In Camera-type Eye Protein Folding Muscle Contraction Tubulin Complex Assembly Muscle Organ Development Response To Heat Negative Regulation Of Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Cell Growth Microtubule Polymerization Or Depolymerization Negative Regulation Of Protein-containing Complex Assembly Response To Estradiol Negative Regulation Of Intracellular Transport Protein Refolding Response To Hydrogen Peroxide Camera-type Eye Development Negative Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Negative Regulation Of DNA-templated Transcription Protein Stabilization Stress-activated MAPK Cascade Apoptotic Process Involved In Morphogenesis Cellular Response To Gamma Radiation Negative Regulation Of Amyloid Fibril Formation Negative Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		None	HSF1-dependent transactivation
Diseases		None	Myofibrillar myopathies (MFM), including: Desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Myotilinopathy (MFM3); Zaspopathy (MFM4); Filaminopathy (MFM5); Bag3opathy Distal muscular dystrophies, including: Welander distal myopathy (WDM); Tibial muscular dystrophy (TMD); Nonaka distal myopathy with rimmed vacuoles (DMRV); Miyoshi myopathy (MM); Laing myopathy (MPD1); Distal nebulin myopathy (DNM); Distal desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Distal myotilinopathy (MFM3); Distal zaspopathy (MFM4); Distal myopathy 3 (MPD2, VCPDM)
GWAS		Daytime nap ( 33568662 )	Birth weight ( 31043758 ) Hip circumference adjusted for BMI ( 34021172 ) PR interval ( 32439900 )
Interacting Genes		3 interacting genes: CRYAA CRYAB CRYGC	57 interacting genes: - ACOT7 APOC2 APP AVP B2M BAG3 BCL2L1 BMPR2 CAPN3 CASP3 CCL22 CCND1 CRYAA CRYBA1 CRYBB2 CRYGC CRYGD CRYGS CS DDX20 DES EPB41 FCGR2A FGF2 GFAP GORASP2 HBA1 HSPB1 HSPB2 HSPB6 HSPB8 INS KRTAP19-5 KRTAP6-1 KRTAP8-1 LALBA LBH MDH2 MIP MRPL11 NGF PRKAG3 PRNP PSMA3 RBM11 SCN5A SLC13A1 SNCA SOD1 SQSTM1 TIAM1 TNPO2 TRAPPC6A TTN UBE2D1 VEGFA
Entrez ID		1421	1410
HPRD ID		00436	00428
Ensembl ID		ENSG00000118231	ENSG00000109846
Uniprot IDs		A0A140CTX7 P07320	A0A024R3B9 P02511 V9HW27
PDB IDs		1H4A 1HK0 2G98 2KFB 2KLJ 4GR7 4JGF 6ETA 6ETC 6W5B 6WCY 7P53 8BD0 8BPI 8Q3L	2KLR 2N0K 2WJ7 2Y1Y 2Y1Z 2Y22 2YGD 3J07 3L1G 3SGM 3SGN 3SGO 3SGP 3SGR 3SGS 4M5S 4M5T 5VVV 6BP9 7ROJ 9BEE
GO Terms Enriched among Interactors		Structural Constituent Of Eye Lens Lens Development In Camera-type Eye Tubulin Complex Assembly Apoptotic Process Involved In Morphogenesis Protein Refolding Apoptotic Process Involved In Development Negative Regulation Of Intracellular Transport Response To Heat Camera-type Eye Development Response To Hydrogen Peroxide Unfolded Protein Binding Eye Development Response To Temperature Stimulus Response To Reactive Oxygen Species Structural Molecule Activity Sensory Organ Development Visual Perception Sensory Perception Of Light Stimulus Protein Folding Protein Stabilization System Process Regulation Of Intracellular Transport Response To Hypoxia Response To Decreased Oxygen Levels Lens Fiber Cell Morphogenesis Response To Oxygen Levels Cardiac Myofibril Response To Oxidative Stress Regulation Of Protein Stability Regulation Of Cell Growth Actin Filament Bundle Negative Regulation Of Transport Response To Radiation Sensory Perception Response To UV-A Contractile Muscle Fiber Lens Morphogenesis In Camera-type Eye Negative Regulation Of Amyloid Fibril Formation Embryonic Camera-type Eye Morphogenesis Regulation Of Cellular Localization Regulation Of Amyloid Fibril Formation Regulation Of Growth Stress-activated MAPK Cascade Embryonic Eye Morphogenesis M Band I Band Stress-activated Protein Kinase Signaling Cascade Cellular Response To Gamma Radiation Protein-containing Complex Microtubule-based Process	Structural Constituent Of Eye Lens Lens Development In Camera-type Eye Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Response To Stress Negative Regulation Of Programmed Cell Death Regulation Of Neuron Apoptotic Process Negative Regulation Of Apoptotic Process Identical Protein Binding System Process Protein Refolding Regulation Of Transport Response To Metal Ion Regulation Of Autophagy Response To Heat Sensory Perception Regulation Of Multicellular Organismal Process Nervous System Process Apoptotic Process Programmed Cell Death Cellular Response To Metal Ion Positive Regulation Of Growth Cell Death Response To Oxidative Stress Visual Perception Sensory Perception Of Light Stimulus Regulation Of Growth Response To Copper Ion Regulation Of Cell Population Proliferation Positive Regulation Of Multicellular Organismal Process Z Disc Neuron Projection Maintenance Regulation Of Dendritic Spine Maintenance Cellular Response To Stress Response To Unfolded Protein Positive Regulation Of Apoptotic Process Response To Temperature Stimulus Positive Regulation Of Endothelial Cell Chemotaxis Regulation Of Long-term Synaptic Potentiation Regulation Of Protein Localization To Cell Periphery Positive Regulation Of Programmed Cell Death Positive Regulation Of Small Molecule Metabolic Process Positive Regulation Of Endocytosis Cytosol Positive Regulation Of Transport Positive Regulation Of Protein Localization Response To Reactive Oxygen Species Positive Regulation Of Cell Growth Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Ovarian Follicle Development