APOC2 and IFI27

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		APOC2	IFI27
Description		apolipoprotein C2	interferon alpha inducible protein 27
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Early Endosome Very-low-density Lipoprotein Particle Low-density Lipoprotein Particle Intermediate-density Lipoprotein Particle High-density Lipoprotein Particle Spherical High-density Lipoprotein Particle Chylomicron	Nucleus Nuclear Envelope Nuclear Inner Membrane Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Mitochondrial Membrane
	Molecular Function	Protein Binding Enzyme Activator Activity Lipid Binding Phospholipase Activator Activity Identical Protein Binding Phospholipase Binding Lipase Inhibitor Activity Lipoprotein Lipase Activator Activity Molecular Function Activator Activity	Protein Binding Lamin Binding Identical Protein Binding Molecular Adaptor Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding
	Biological Process	Lipid Metabolic Process Lipid Transport Positive Regulation Of Triglyceride Catabolic Process Positive Regulation Of Very-low-density Lipoprotein Particle Remodeling Negative Regulation Of Very-low-density Lipoprotein Particle Clearance Lipid Catabolic Process Negative Regulation Of Cholesterol Transport Cholesterol Efflux Phospholipid Efflux Triglyceride-rich Lipoprotein Particle Remodeling Chylomicron Remodeling Very-low-density Lipoprotein Particle Remodeling Chylomicron Remnant Clearance High-density Lipoprotein Particle Clearance Lipoprotein Catabolic Process Cholesterol Homeostasis Reverse Cholesterol Transport Positive Regulation Of Fatty Acid Biosynthetic Process Negative Regulation Of Lipid Metabolic Process Negative Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Phospholipid Catabolic Process Triglyceride Homeostasis	Negative Regulation Of Transcription By RNA Polymerase II Immune System Process Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Host-mediated Perturbation Of Viral Genome Replication Innate Immune Response Regulation Of Protein Export From Nucleus Defense Response To Virus Type I Interferon-mediated Signaling Pathway Pyroptotic Inflammatory Response Protein K48-linked Ubiquitination Extrinsic Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway
Pathways		Chylomicron assembly Assembly of active LPL and LIPC lipase complexes Chylomicron remodeling HDL remodeling NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux Retinoid metabolism and transport Retinoid metabolism and transport	Interferon alpha/beta signaling Modulation of host responses by IFN-stimulated genes
Drugs		Copper
Diseases		Hyperlipoproteinemia, type I
GWAS		Alzheimer's disease (onset between ages 58 and 79) ( 30979435) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Carotid intima media thickness (maximum) ( 31801372) Carotid intima media thickness (mean) ( 31801372) Cerebrospinal AB1-42 levels in Alzheimer's disease dementia ( 29274321) Cerebrospinal AB1-42 levels in mild cognitive impairment ( 29274321) Cerebrospinal AB1-42 levels in normal cognition ( 29274321) Cerebrospinal fluid AB1-42 levels ( 29274321) Cerebrospinal fluid p-tau levels ( 29274321) Cerebrospinal fluid p-tau levels in mild cognitive impairment ( 29274321) Cerebrospinal fluid t-tau levels ( 29274321) Cerebrospinal fluid t-tau levels in mild cognitive impairment ( 29274321) Cholesterol, total ( 20686565) HDL cholesterol ( 20686565) HDL cholesterol levels ( 28334899) Hippocampal volume ( 29274321) Hippocampal volume in Alzheimer's disease dementia ( 29274321) LDL cholesterol ( 18802019 20864672 20686565 19060906 18193044) LDL cholesterol levels ( 28334899) Lipid metabolism phenotypes ( 22286219) Logical memory (delayed recall) ( 29274321) Logical memory (immediate recall) ( 29274321) Low density lipoprotein cholesterol levels ( 28548082) Quantitative traits ( 19197348) Total cholesterol levels ( 28548082 28334899) Triglyceride levels ( 28334899) Triglycerides ( 20686565) Very long-chain saturated fatty acid levels (fatty acid 20:0) ( 25378659)
Interacting Genes		28 interacting genes: APOL2 BCL2L2 CFTR CRYAB DIABLO GAD2 GSDMA IFI27 LETMD1 LPL MAIP1 MICOS10 MICOS13 NFU1 PORCN RSAD2 SENP2 SNAP47 SNCA SYT16 TBC1D20 THBD TIMMDC1 TMEM14B TPRG1 TTPA UBQLN1 UBQLN2	4 interacting genes: APOC2 APOC4 CCND1 CDK4
Entrez ID		344	3429
HPRD ID		07457	02479
Ensembl ID		ENSG00000234906	ENSG00000165949
Uniprot IDs		A0A024R0T9 P02655	P40305
PDB IDs		1BY6 1I5J 1O8T 1SOH
Enriched GO Terms of Interacting Partners?		Mitochondrion Mitochondrion Organization Mitochondrial Inner Membrane Membrane Very-low-density Lipoprotein Particle Clearance Mitochondrial Outer Membrane Mitochondrial Membrane Organization Inner Mitochondrial Membrane Organization Mitochondrial Crista Junction Lipoprotein Particle Binding Virion Assembly Very-low-density Lipoprotein Particle Remodeling Positive Regulation Of Amyloid-beta Clearance Negative Regulation Of Transport MICOS Complex Triglyceride-rich Lipoprotein Particle Remodeling SAM Complex MIB Complex Organelle Organization Host-mediated Perturbation Of Viral Genome Replication Cristae Formation Regulation Of Transport Chylomicron Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Negative Regulation Of Amyloid Fibril Formation Mitochondrial Membrane Host-mediated Perturbation Of Viral Process Regulation Of Vesicle-mediated Transport Neutral Lipid Metabolic Process Heparan Sulfate Proteoglycan Binding Regulation Of Amyloid Fibril Formation Negative Regulation Of Platelet Activation Synaptic Vesicle Priming Positive Regulation Of ERAD Pathway Very-low-density Lipoprotein Particle High-density Lipoprotein Particle Remodeling Regulation Of Amyloid-beta Clearance Calcium Ion Homeostasis Mitochondrial Calcium Ion Homeostasis Protein Binding Membrane Organization Host-mediated Perturbation Of Symbiont Process Regulation Of ERAD Pathway Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Negative Regulation Of Phospholipid Efflux Lipoprotein Metabolic Process Sterol Metabolic Process Monoatomic Ion Homeostasis Negative Regulation Of Postsynaptic Membrane Organization Positive Regulation Of Lipid Transport Across Blood-brain Barrier	Cyclin D1-CDK4 Complex High-density Lipoprotein Particle Very-low-density Lipoprotein Particle Positive Regulation Of Cell Cycle G2/M Phase Transition Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Acylglycerol Homeostasis Triglyceride Homeostasis Cyclin-dependent Protein Kinase Holoenzyme Complex Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Very-low-density Lipoprotein Particle Remodeling Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Phase Transition Kinase Activity Regulation Of Cell Cycle G2/M Phase Transition Positive Regulation Of Mitotic Cell Cycle Cyclin D1-CDK6 Complex Regulation Of G2/M Transition Of Mitotic Cell Cycle Bicellular Tight Junction Cyclin D3-CDK4 Complex Futile Creatine Cycle Positive Regulation Of Phospholipid Catabolic Process Lipoprotein Lipase Activator Activity Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Cyclin D2-CDK4 Complex Lipid Homeostasis Negative Regulation Of Very-low-density Lipoprotein Particle Clearance Chylomicron Remodeling Re-entry Into Mitotic Cell Cycle Chylomicron Remnant Clearance Triglyceride-rich Lipoprotein Particle Clearance Intermediate-density Lipoprotein Particle Positive Regulation Of Mammary Gland Epithelial Cell Proliferation Response To Ketone Cellular Response To Ionomycin Phosphocreatine Biosynthetic Process Creatine Kinase Activity Spherical High-density Lipoprotein Particle Positive Regulation Of Triglyceride Catabolic Process Regulation Of Phospholipid Catabolic Process Lipase Inhibitor Activity Very-low-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Clearance Positive Regulation Of Cell Cycle Process Response To Vitamin E Nuclear Membrane Response To Alcohol Triglyceride-rich Lipoprotein Particle Remodeling
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