APOC2

Gene Name		apolipoprotein C-II
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Early Endosome Very-low-density Lipoprotein Particle Low-density Lipoprotein Particle Intermediate-density Lipoprotein Particle Spherical High-density Lipoprotein Particle Chylomicron Extracellular Vesicular Exosome
	Molecular Function	Lipid Binding Phospholipase Activator Activity Protein Homodimerization Activity Phospholipase Binding Lipase Inhibitor Activity Lipoprotein Lipase Activator Activity
	Biological Process	Retinoid Metabolic Process Phototransduction, Visible Light Positive Regulation Of Phospholipase Activity Positive Regulation Of Triglyceride Catabolic Process Positive Regulation Of Very-low-density Lipoprotein Particle Remodeling Negative Regulation Of Very-low-density Lipoprotein Particle Clearance Lipid Catabolic Process Negative Regulation Of Cholesterol Transport Cholesterol Efflux Phospholipid Efflux Triglyceride-rich Lipoprotein Particle Remodeling Chylomicron Remodeling Very-low-density Lipoprotein Particle Remodeling Chylomicron Remnant Clearance High-density Lipoprotein Particle Clearance Lipoprotein Metabolic Process Cholesterol Homeostasis Negative Regulation Of Catalytic Activity Reverse Cholesterol Transport Small Molecule Metabolic Process Positive Regulation Of Fatty Acid Biosynthetic Process Negative Regulation Of Lipid Metabolic Process Negative Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Lipoprotein Lipase Activity Positive Regulation Of Phospholipid Catabolic Process Triglyceride Homeostasis
Pathways		Lipoprotein metabolism HDL-mediated lipid transport Visual phototransduction Metabolism of lipids and lipoproteins Chylomicron-mediated lipid transport Lipid digestion, mobilization, and transport Diseases associated with visual transduction Retinoid metabolism and transport
Drugs
Diseases
GWAS		Cholesterol, total ( 20686565) HDL cholesterol ( 20686565) LDL cholesterol ( 18802019 18193044 20864672 19060906 20686565) Lipid metabolism phenotypes ( 22286219) Quantitative traits ( 19197348) Triglycerides ( 20686565)
Protein-protein Interactions		2 interactors: CRYAB LPL
Entrez ID		344
HPRD ID		07457
Ensembl ID		ENSG00000234906
Uniprot IDs		P02655
PDB IDs		1BY6 1I5J 1O8T 1SOH
Enriched GO Terms of Interacting Partners?		Chylomicron Remodeling Response To Radiation Positive Regulation Of Sequestering Of Triglyceride Tubulin Complex Assembly Very-low-density Lipoprotein Particle Remodeling Triglyceride-rich Lipoprotein Particle Remodeling Positive Regulation Of Cholesterol Storage Triglyceride Catabolic Process Apoptotic Process Involved In Morphogenesis Cellular Response To Gamma Radiation Acylglycerol Catabolic Process Apoptotic Process Involved In Development Response To Abiotic Stimulus Plasma Lipoprotein Particle Remodeling Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Lipid Storage Triglyceride Homeostasis Developmental Programmed Cell Death Microtubule Polymerization Or Depolymerization Acylglycerol Homeostasis Negative Regulation Of Reactive Oxygen Species Metabolic Process Triglyceride Biosynthetic Process Regulation Of Macrophage Derived Foam Cell Differentiation Response To Gamma Radiation Response To Cold Regulation Of Lipid Storage Cellular Response To Ionizing Radiation Regulation Of Plasma Lipoprotein Particle Levels Phototransduction, Visible Light Retinoid Metabolic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Diterpenoid Metabolic Process Detection Of Visible Light Triglyceride Metabolic Process Lens Development In Camera-type Eye Phototransduction Neutral Lipid Metabolic Process Detection Of Light Stimulus Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Lipid Homeostasis Negative Regulation Of Intracellular Transport Response To Estradiol Response To Hydrogen Peroxide Isoprenoid Metabolic Process Fatty Acid Biosynthetic Process Cellular Response To Radiation Response To Ionizing Radiation Cellular Lipid Catabolic Process
Tagcloud ?		atp1a3 bckdha cgb cgm2 cyp2a d19s112 d19s116 d19s117 d19s118 d19s119 d19s19 d19s2 d19s37 d19s50 d19s51 d19s54 d19s55 d19s6 d19s62 d19s63 d19s7 d19s8 d19s9 manb pepd prkcg psg1 pw39 tnnt1