POM121 and CLDN3

Number of citations: 0 (PubMedID 16169070)
Data Source: HPRD (two hybrid)

		POM121	CLDN3
Name		POM121 transmembrane nucleoporin	claudin 3
Structure			No pdb structure
GO Annotations	Cellular Component	Nucleus Nuclear Envelope Nuclear Pore Nucleoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Nuclear Membrane	Plasma Membrane Cell-cell Junction Bicellular Tight Junction Membrane Apicolateral Plasma Membrane Lateral Plasma Membrane Protein-containing Complex Apical Junction Complex Tight Junction Anchoring Junction
	Molecular Function	Protein Binding Nuclear Localization Sequence Binding Structural Constituent Of Nuclear Pore	Transmembrane Signaling Receptor Activity Structural Molecule Activity Protein Binding Identical Protein Binding Cell-cell Adhesion Mediator Activity
	Biological Process	RNA Export From Nucleus Protein Import Into Nucleus Nucleocytoplasmic Transport Protein Transport MRNA Transport	Response To Hypoxia Epithelial Cell Morphogenesis Retinal Pigment Epithelium Development Cell Adhesion Negative Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Establishment Of Endothelial Blood-brain Barrier Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Regulation Of Cell Morphogenesis Actin Cytoskeleton Organization Positive Regulation Of Cell Migration Negative Regulation Of Cell Migration Cell Junction Assembly Cell Junction Maintenance Maintenance Of Blood-brain Barrier Cell-cell Junction Maintenance Response To Ethanol Bicellular Tight Junction Assembly Positive Regulation Of Wound Healing Regulation Of Membrane Permeability Response To Gram-positive Bacterium Regulation Of Transepithelial Transport Negative Regulation Of Phosphate Transmembrane Transport
Pathways		ISG15 antiviral mechanism Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs IPs transport between nucleus and cytosol IP3 and IP4 transport between cytosol and nucleus IP6 and IP7 transport between cytosol and nucleus snRNP Assembly SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) tRNA processing in the nucleus HCMV Early Events HCMV Late Events Postmitotic nuclear pore complex (NPC) reformation Postmitotic nuclear pore complex (NPC) reformation SARS-CoV-2 activates/modulates innate and adaptive immune responses	Tight junction interactions
GWAS		Hip circumference adjusted for BMI ( 34021172 ) Hip index ( 34021172 ) Subcutaneous adipose tissue ( 22589738 ) Triglyceride levels ( 32203549 )	Mean platelet volume ( 27863252 ) Platelet distribution width ( 27863252 )
Novel Interactors		None recorded	1 novel interactors: EPHB4
Interacting Genes		42 interacting genes: AGR2 AP1B1 AP2B1 APC ATXN1 BOLL BRCA1 CCDC57 CEACAM6 CEP55 CEP76 CERT1 CLDN3 COG6 FAM168B FXR2 GFAP GOLGA2 GYG1 HOMER3 JMJD7 KPNA6 LPXN MAGED1 MORN5 NFKBIA OTUD6A PAXIP1 RBPMS SPAG5 STAT3 TEX11 TFIP11 TOX3 TRAF2 TRAF3 TRIM23 TRIM27 TRIM49 TRIP6 UBQLN2 ZMYND12	7 interacting genes: APP CLDN1 CLDN5 POM121 PRKACA TJP1 WNK4
Entrez ID		9883	1365
HPRD ID		11448	04219
Ensembl ID		ENSG00000196313	ENSG00000165215
Uniprot IDs		Q96HA1	O15551 Q75L79
PDB IDs		5T6W	Not available
GO Terms Enriched among Interactors		Identical Protein Binding Protein Binding Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Cytoplasm Positive Regulation Of Macromolecule Biosynthetic Process Intracellular Transport Protein Kinase Binding Positive Regulation Of Biosynthetic Process Positive Regulation Of Gene Expression Signal Transduction Involved In Regulation Of Gene Expression Establishment Of Protein Localization Establishment Of Localization In Cell Ubiquitin Protein Ligase Activity Intracellular Protein Transport Regulation Of Autophagy Thioesterase Binding CD40 Receptor Complex Clathrin Adaptor Complex Ubiquitin-protein Transferase Activity Tumor Necrosis Factor-mediated Signaling Pathway Cytosol Positive Regulation Of Multicellular Organismal Process Negative Regulation Of DNA-binding Transcription Factor Activity Response To Stress Transcription Coactivator Activity Regulation Of Cytokine Production Cellular Localization Ubiquitin Protein Ligase Binding Protein Transport Regulation Of DNA-binding Transcription Factor Activity Protein Localization To Nucleus Signaling Adaptor Activity Microtubule Organizing Center Organization Regulation Of Cytokine Production Involved In Inflammatory Response	Regulation Of Bicellular Tight Junction Assembly Regulation Of Cell Junction Assembly Bicellular Tight Junction Maintenance Of Blood-brain Barrier Tight Junction Multicellular Organismal-level Homeostasis Homeostatic Process Positive Regulation Of Bicellular Tight Junction Assembly Cell Adhesion Establishment Of Endothelial Intestinal Barrier Cell-cell Junction Assembly Anchoring Junction Response To Lead Ion Cell Junction Organization Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Cell-cell Junction Organization Anatomical Structure Homeostasis Tissue Homeostasis Cell Junction Establishment Of Endothelial Barrier Endothelial Cell Development System Process Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Vascular Permeability Cell Junction Assembly Bicellular Tight Junction Assembly Regulation Of Glycolytic Process Regulation Of Monoatomic Ion Transmembrane Transport Protein-containing Complex Cell Junction Maintenance Tight Junction Assembly Tight Junction Organization Positive Regulation Of Calcium-mediated Signaling Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of Carbohydrate Catabolic Process Macrophage Activation Amylin Binding Positive Regulation Of Toll Signaling Pathway Cell Development Regulation Of Metal Ion Transport Cellular Component Maintenance Lateral Plasma Membrane Xenobiotic Transport Across Blood-nerve Barrier Aldosterone Secretion Regulation Of ATP Metabolic Process Membrane Regulation Of Cell Migration Cell Body