POM121 and AP1B1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		POM121	AP1B1
Description		POM121 transmembrane nucleoporin	adaptor related protein complex 1 subunit beta 1
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GO Annotations	Cellular Component	Nucleus Nuclear Envelope Nuclear Pore Nucleoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Nuclear Membrane	Golgi Membrane Lysosomal Membrane Early Endosome Golgi Apparatus Cytosol Synaptic Vesicle Endomembrane System Membrane Membrane Coat AP-1 Adaptor Complex Clathrin Adaptor Complex Cytoplasmic Vesicle Membrane Clathrin-coated Vesicle Membrane Cytoplasmic Vesicle Trans-Golgi Network Membrane
	Molecular Function	Protein Binding Nuclear Localization Sequence Binding Structural Constituent Of Nuclear Pore	Protein Binding Protein Kinase Binding Clathrin Binding
	Biological Process	RNA Export From Nucleus Protein Import Into Nucleus Nucleocytoplasmic Transport Protein Transport MRNA Transport	Kidney Development Intracellular Protein Transport Determination Of Left/right Symmetry Heart Development Protein Transport Vesicle-mediated Transport Platelet Dense Granule Organization Basolateral Protein Secretion Melanosome Assembly
Pathways		ISG15 antiviral mechanism Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs IPs transport between nucleus and cytosol IP3 and IP4 transport between cytosol and nucleus IP6 and IP7 transport between cytosol and nucleus snRNP Assembly SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) tRNA processing in the nucleus HCMV Early Events HCMV Late Events Postmitotic nuclear pore complex (NPC) reformation Postmitotic nuclear pore complex (NPC) reformation SARS-CoV-2 activates/modulates innate and adaptive immune responses	Nef mediated downregulation of MHC class I complex cell surface expression MHC class II antigen presentation Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis
Drugs
Diseases
GWAS		Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Subcutaneous adipose tissue ( 22589738) Triglyceride levels ( 32203549)	Aspartate aminotransferase levels ( 33547301) Carotid atherosclerosis in HIV infection ( 20009918) Haemorrhoidal disease ( 33888516) Heel bone mineral density ( 28869591 30598549) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 27863252 32888494) Pancreatic cancer ( 25086665) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		42 interacting genes: AGR2 AP1B1 AP2B1 APC ATXN1 BOLL BRCA1 CCDC57 CEACAM6 CEP55 CEP76 CERT1 CLDN3 COG6 FAM168B FXR2 GFAP GOLGA2 GYG1 HOMER3 JMJD7 KPNA6 LPXN MAGED1 MORN5 NFKBIA OTUD6A PAXIP1 RBPMS SPAG5 STAT3 TEX11 TFIP11 TOX3 TRAF2 TRAF3 TRIM23 TRIM27 TRIM49 TRIP6 UBQLN2 ZMYND12	45 interacting genes: - AGR3 AP1G1 AP1M2 ARF1 ARF5 ARF6 ARRB2 ATF7IP ATM ATR BARD1 BUB1 BUB1B CEBPA CLTC CREBBP CRYBB1 FARS2 FILNC1 FMNL2 FNDC11 GPANK1 GTF2I KIF13A LDLRAP1 MLH1 MSGN1 MTNR1B MYG1 NECAP1 NTRK2 NUP54 PIP5K1C PLK2 POM121 PRKDC PSORS1C2 RNF39 SHBG SLC2A8 SMAD2 TBC1D22B TSGA10IP U2AF1
Entrez ID		9883	162
HPRD ID		11448	02541
Ensembl ID		ENSG00000196313	ENSG00000100280
Uniprot IDs		Q96HA1	Q10567
PDB IDs		5T6W	4HMY 4P6Z 6CM9 6CRI 6D83 6D84 6DFF 7R4H 7UX3 8D4C 8D4D 8D4E 8D4F 8D4G 8D9R 8D9S 8D9T 8D9U 8D9V 8D9W
Enriched GO Terms of Interacting Partners?		Identical Protein Binding Protein Binding Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Cytoplasm Positive Regulation Of Macromolecule Biosynthetic Process Intracellular Transport Protein Kinase Binding Positive Regulation Of Biosynthetic Process Positive Regulation Of Gene Expression Signal Transduction Involved In Regulation Of Gene Expression Establishment Of Protein Localization Establishment Of Localization In Cell Ubiquitin Protein Ligase Activity Intracellular Protein Transport Regulation Of Autophagy Thioesterase Binding CD40 Receptor Complex Clathrin Adaptor Complex Ubiquitin-protein Transferase Activity Tumor Necrosis Factor-mediated Signaling Pathway Cytosol Positive Regulation Of Multicellular Organismal Process Negative Regulation Of DNA-binding Transcription Factor Activity Response To Stress Transcription Coactivator Activity Regulation Of Cytokine Production Cellular Localization Ubiquitin Protein Ligase Binding Protein Transport Regulation Of DNA-binding Transcription Factor Activity Protein Localization To Nucleus Signaling Adaptor Activity Microtubule Organizing Center Organization Regulation Of Cytokine Production Involved In Inflammatory Response	Histone H2AXS139 Kinase Activity Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Process Presynaptic Endocytosis Establishment Of RNA Localization To Telomere Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition DNA Strand Resection Involved In Replication Fork Processing Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Telomerase Catalytic Core Complex Assembly Negative Regulation Of Cell Cycle Regulation Of Cellular Response To Heat Intracellular Protein Localization Regulation Of Cell Cycle Clathrin Adaptor Activity Negative Regulation Of Cell Cycle Process Establishment Of Protein Localization DNA-dependent Protein Kinase Activity Intracellular Protein Transport Meiotic Sister Chromatid Cohesion, Centromeric Regulation Of Cell Cycle Phase Transition Clathrin-coated Pit Protein Transport Basolateral Protein Secretion Mitotic Spindle Assembly Checkpoint Signaling Negative Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Mitotic Cell Cycle Clathrin-coated Vesicle Membrane Vesicle-mediated Transport In Synapse MutSalpha Complex Binding Homologous Recombination Synaptic Vesicle Endocytosis Negative Regulation Of Mitotic Nuclear Division Meiotic Telomere Clustering Chromosome Localization To Nuclear Envelope Involved In Homologous Chromosome Segregation RNA Polymerase II-specific DNA-binding Transcription Factor Binding Telomere Localization Protein Localization To Chromosome Somatic Cell DNA Recombination Trans-Golgi Network Membrane Endocytosis Somitogenesis Meiotic Sister Chromatid Cohesion Male Meiotic Nuclear Division Nucleotide Binding Regulation Of Receptor-mediated Endocytosis Segmentation Response To Gamma Radiation Mitotic G2/M Transition Checkpoint
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