POM121 and TRIM49

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		POM121	TRIM49
Description		POM121 transmembrane nucleoporin	tripartite motif containing 49
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nuclear Envelope Nuclear Pore Nucleoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Nuclear Membrane	Cytoplasm
	Molecular Function	Protein Binding Nuclear Localization Sequence Binding Structural Constituent Of Nuclear Pore	Protein Binding Zinc Ion Binding Protein Kinase Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	RNA Export From Nucleus Protein Import Into Nucleus Nucleocytoplasmic Transport Protein Transport MRNA Transport	Regulation Of Gene Expression Innate Immune Response
Pathways		ISG15 antiviral mechanism Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs IPs transport between nucleus and cytosol IP3 and IP4 transport between cytosol and nucleus IP6 and IP7 transport between cytosol and nucleus snRNP Assembly SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) tRNA processing in the nucleus HCMV Early Events HCMV Late Events Postmitotic nuclear pore complex (NPC) reformation Postmitotic nuclear pore complex (NPC) reformation SARS-CoV-2 activates/modulates innate and adaptive immune responses
Drugs
Diseases
GWAS		Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Subcutaneous adipose tissue ( 22589738) Triglyceride levels ( 32203549)	Intraocular pressure ( 30591961) Response to taxane treatment (docetaxel) ( 23006423) Serum metabolite levels ( 33031748)
Interacting Genes		42 interacting genes: AGR2 AP1B1 AP2B1 APC ATXN1 BOLL BRCA1 CCDC57 CEACAM6 CEP55 CEP76 CERT1 CLDN3 COG6 FAM168B FXR2 GFAP GOLGA2 GYG1 HOMER3 JMJD7 KPNA6 LPXN MAGED1 MORN5 NFKBIA OTUD6A PAXIP1 RBPMS SPAG5 STAT3 TEX11 TFIP11 TOX3 TRAF2 TRAF3 TRIM23 TRIM27 TRIM49 TRIP6 UBQLN2 ZMYND12	4 interacting genes: BLM LGALS8 MINDY3 POM121
Entrez ID		9883	57093
HPRD ID		11448	05840
Ensembl ID		ENSG00000196313	ENSG00000168930
Uniprot IDs		Q96HA1	E9PK69 P0CI25
PDB IDs		5T6W
Enriched GO Terms of Interacting Partners?		Identical Protein Binding Protein Binding Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Cytoplasm Positive Regulation Of Macromolecule Biosynthetic Process Intracellular Transport Protein Kinase Binding Positive Regulation Of Biosynthetic Process Positive Regulation Of Gene Expression Signal Transduction Involved In Regulation Of Gene Expression Establishment Of Protein Localization Establishment Of Localization In Cell Ubiquitin Protein Ligase Activity Intracellular Protein Transport Regulation Of Autophagy Thioesterase Binding CD40 Receptor Complex Clathrin Adaptor Complex Ubiquitin-protein Transferase Activity Tumor Necrosis Factor-mediated Signaling Pathway Cytosol Positive Regulation Of Multicellular Organismal Process Negative Regulation Of DNA-binding Transcription Factor Activity Response To Stress Transcription Coactivator Activity Regulation Of Cytokine Production Cellular Localization Ubiquitin Protein Ligase Binding Protein Transport Regulation Of DNA-binding Transcription Factor Activity Protein Localization To Nucleus Signaling Adaptor Activity Microtubule Organizing Center Organization Regulation Of Cytokine Production Involved In Inflammatory Response	8-hydroxy-2'-deoxyguanosine DNA Binding DNA Geometric Change Forked DNA-dependent Helicase Activity Resolution Of DNA Recombination Intermediates Telomeric G-quadruplex DNA Binding DNA/DNA Annealing Activity RecQ Family Helicase-topoisomerase III Complex Telomeric D-loop Binding Four-way Junction Helicase Activity Telomeric D-loop Disassembly Cellular Response To Camptothecin Bubble DNA Binding Y-form DNA Binding G-quadruplex DNA Binding Telomere Maintenance Via Semi-conservative Replication Lymphatic Endothelial Cell Migration Xenophagy Plasma Cell Differentiation Nuclear Membrane T-circle Formation Cellular Response To Hydroxyurea Response To Hydroxyurea Telomeric Loop Disassembly Hydrolase Activity, Acting On Acid Anhydrides, In Phosphorus-containing Anhydrides 3'-5' DNA Helicase Activity Lateral Element Negative Regulation Of Cell Division Four-way Junction DNA Binding DNA Conformation Change K48-linked Deubiquitinase Activity Structural Constituent Of Nuclear Pore Nuclear Localization Sequence Binding DNA Double-strand Break Processing
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