CPT1A and CLIC1

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		CPT1A	CLIC1
Name		carnitine palmitoyltransferase 1A	chloride intracellular channel 1
Structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Outer Membrane Membrane	Extracellular Space Nucleus Nuclear Envelope Cytoplasm Mitochondrion Endoplasmic Reticulum Plasma Membrane Brush Border Membrane Nuclear Membrane Vesicle Monoatomic Ion Channel Complex Chloride Channel Complex Perinuclear Region Of Cytoplasm Extracellular Exosome Blood Microparticle
	Molecular Function	Carnitine O-palmitoyltransferase Activity Transferase Activity Acyltransferase Activity Protein-macromolecule Adaptor Activity Identical Protein Binding	Chloride Channel Activity Protein Binding Oxidoreductase Activity Cadherin Binding
	Biological Process	Response To Hypoxia Long-chain Fatty Acid Metabolic Process Cytoplasmic Pattern Recognition Receptor Signaling Pathway Glucose Metabolic Process Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Beta-oxidation Triglyceride Metabolic Process Carnitine Shuttle Response To Nutrient Response To Xenobiotic Stimulus Carnitine Metabolic Process Epithelial Cell Differentiation Response To Nutrient Levels Positive Regulation Of Fatty Acid Beta-oxidation Eating Behavior Response To Alkaloid Positive Regulation Of Innate Immune Response Response To Ethanol Aflatoxin Metabolic Process Regulation Of Fatty Acid Oxidation Regulation Of Insulin Secretion Cellular Response To Fatty Acid Liver Regeneration Response To Tetrachloromethane	Monoatomic Ion Transport Chloride Transport Signal Transduction Monoatomic Ion Transmembrane Transport Positive Regulation Of Osteoblast Differentiation Regulation Of Mitochondrial Membrane Potential Platelet Aggregation Chloride Transmembrane Transport
Pathways		PPARA activates gene expression Carnitine shuttle RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	None
Drugs		Levocarnitine Glyburide Perhexiline	Copper Artenimol
Diseases		Disorders of fatty-acid oxidation, including: Medium-chain (MC) acyl-CoA dehydrogenase (AD) deficiency (MCADD); Short-chain AD deficiency (SCADD) ; Short-branched-chain AD deficiency (SBCADD) ; Very long-chain AD deficiency (VLCADD) ; Long-chain 3-hydroxyacyl CoA dehydrogenase deficiency (LCHADD) ; Trifunctional protein deficiency (TFP); Carnitine palmitoyltransferase deficiency (CPT); Carnitine-acylcarnitine translocase deficiency (CACT); Systemic primary carnitine deficiency (CDSP)	None
GWAS		Apolipoprotein A1 levels ( 32203549 ) Coronary artery calcified atherosclerotic plaque score in type 2 diabetes ( 29221444 ) HDL cholesterol levels ( 32203549 ) Lipid metabolism phenotypes ( 22286219 ) Lipid traits (pleiotropy) (HIPO component 1) ( 30289880 ) Obesity-related traits ( 23251661 ) Serum metabolite levels ( 31636271 ) Serum metabolite levels (CMS) ( 31636271 ) Triglyceride levels ( 32154731 32203549 ) Urate levels ( 31578528 )	Adult body size ( 32376654 ) Asthma ( 31619474 ) Asthma (childhood onset) ( 31619474 ) Asthma and major depressive disorder ( 31619474 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Inflammatory bowel disease ( 28067908 ) Mean platelet volume ( 27863252 ) Ulcerative colitis ( 28067908 )
Novel Interactors		None recorded	2 novel interactors: DNAJC19 PCSK5
Interacting Genes		8 interacting genes: BCL2 CLIC1 CYBA HSPA5 KBTBD7 NPDC1 NR4A1 UBC	25 interacting genes: AKAP9 ALOX5AP ANXA1 ATP5PB ATP6V0A1 ATP6V0C CEBPA CFTR CPT1A IKBKG LSM1 MEOX2 MYOC NHSL2 NTF4 NUP62 PRDX4 PSMD10 RPLP1 SUMO4 THRA TPRN TRAPPC2 ZNF184 ZNF302
Entrez ID		1374	1192
HPRD ID		02755	04188
Ensembl ID		ENSG00000110090	ENSG00000213719
Uniprot IDs		B2RAQ8 P50416 Q8WZ48	O00299 Q53FB0 Q5SRT3
PDB IDs		2LE3	1K0M 1K0N 1K0O 1RK4 3O3T 3P8W 3P90 3QR6 3SWL 3TGZ 3UVH 4IQA 4JZQ 4K0G 4K0N 7F8R 7FBQ
GO Terms Enriched among Interactors		Negative Regulation Of Retinal Cell Programmed Cell Death Ubiquitin Protein Ligase Binding Regulation Of Mitochondrial Membrane Potential Negative Regulation Of Cellular PH Reduction Neural Nucleus Development Cellular Response To Glucose Starvation Protein Heterodimerization Activity Nuclear Membrane Response To Gamma Radiation Mitochondrion Smooth Muscle Hypertrophy Negative Regulation Of Glomerular Filtration By Angiotensin Regulation Of Protein Folding In Endoplasmic Reticulum Reactive Oxygen Species Metabolic Process CD8-positive, Alpha-beta T Cell Lineage Commitment BAD-BCL-2 Complex Channel Inhibitor Activity Endoplasmic Reticulum Membrane Positive Regulation Of Endothelial Cell Proliferation Cerebellum Structural Organization Negative Regulation Of Calcium Ion Transport Into Cytosol Response To Nutrient Levels Regulation Of Calcium Ion Transmembrane Transport Dendritic Cell Apoptotic Process Cochlear Nucleus Development Protein Ubiquitination Regulation Of Melanocyte Differentiation Response To Hormone Regulation Of Nitrogen Utilization Response To Peptide Regulation Of Retinal Cell Programmed Cell Death Response To Ionizing Radiation Response To Cytokine Positive Regulation Of Melanocyte Differentiation Immune System Development Positive Regulation Of Neuron Maturation Retinal Cell Programmed Cell Death Response To Corticosteroid Cellular Response To L-glutamine Positive Regulation Of Mucus Secretion Regulation Of Renal Output By Angiotensin Regulation Of Endothelial Cell Proliferation Detection Of Lipopolysaccharide Cellular Response To Corticotropin-releasing Hormone Stimulus Regulation Of ATF6-mediated Unfolded Protein Response Positive Regulation Of Cell Growth B Cell Lineage Commitment BH3 Domain Binding Positive Regulation Of Pigment Cell Differentiation Regulation Of Blood Volume By Renin-angiotensin	None