CPT1A and CYBA

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		CPT1A	CYBA
Description		carnitine palmitoyltransferase 1A	cytochrome b-245 alpha chain
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Outer Membrane Membrane	Stress Fiber Cytoplasm Endosome Endoplasmic Reticulum Membrane Plasma Membrane Focal Adhesion Membrane Apical Plasma Membrane Secretory Granule Dendrite Phagocytic Vesicle Membrane Specific Granule Membrane NADPH Oxidase Complex Neuronal Cell Body Tertiary Granule Membrane Perinuclear Endoplasmic Reticulum
	Molecular Function	Carnitine O-palmitoyltransferase Activity Transferase Activity Acyltransferase Activity Protein-macromolecule Adaptor Activity Identical Protein Binding	Protein Binding Electron Transfer Activity Superoxide-generating NAD(P)H Oxidase Activity Oxidoreductase Activity SH3 Domain Binding Heme Binding Metal Ion Binding Protein Heterodimerization Activity
	Biological Process	Response To Hypoxia Long-chain Fatty Acid Metabolic Process Cytoplasmic Pattern Recognition Receptor Signaling Pathway Glucose Metabolic Process Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Beta-oxidation Triglyceride Metabolic Process Carnitine Shuttle Response To Nutrient Response To Xenobiotic Stimulus Carnitine Metabolic Process Epithelial Cell Differentiation Response To Nutrient Levels Positive Regulation Of Fatty Acid Beta-oxidation Eating Behavior Response To Alkaloid Positive Regulation Of Innate Immune Response Response To Ethanol Aflatoxin Metabolic Process Regulation Of Fatty Acid Oxidation Regulation Of Insulin Secretion Cellular Response To Fatty Acid Liver Regeneration Response To Tetrachloromethane	Response To Hypoxia Positive Regulation Of Endothelial Cell Proliferation Negative Regulation Of Glomerular Filtration By Angiotensin Superoxide Metabolic Process Inflammatory Response Response To Xenobiotic Stimulus Response To Activity Smooth Muscle Hypertrophy Cytochrome Complex Assembly Positive Regulation Of Cell Growth Response To Nutrient Levels Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Superoxide Anion Generation Positive Regulation Of Toll-like Receptor 2 Signaling Pathway Superoxide Anion Generation Innate Immune Response Respiratory Burst Positive Regulation Of Blood Pressure Positive Regulation Of Smooth Muscle Cell Proliferation Hydrogen Peroxide Biosynthetic Process Positive Regulation Of Phagocytosis Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Establishment Of Localization In Cell Mucus Secretion Positive Regulation Of Mucus Secretion Response To Interleukin-1 Cellular Response To Mechanical Stimulus Cellular Response To Glucose Stimulus Cellular Response To Tumor Necrosis Factor Cellular Response To Gamma Radiation Reactive Oxygen Species Metabolic Process Positive Regulation Of Defense Response To Bacterium Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Response To Aldosterone Cellular Response To Angiotensin Cellular Response To Phorbol 13-acetate 12-myristate Cellular Response To L-glutamine
Pathways		PPARA activates gene expression Carnitine shuttle RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	ROS and RNS production in phagocytes Cross-presentation of particulate exogenous antigens (phagosomes) Detoxification of Reactive Oxygen Species VEGFA-VEGFR2 Pathway RHO GTPases Activate NADPH Oxidases Neutrophil degranulation RAC1 GTPase cycle RAC2 GTPase cycle RAC3 GTPase cycle WNT5:FZD7-mediated leishmania damping
Drugs		Levocarnitine Glyburide Perhexiline	Dextromethorphan
Diseases		Disorders of fatty-acid oxidation, including: Medium-chain (MC) acyl-CoA dehydrogenase (AD) deficiency (MCADD); Short-chain AD deficiency (SCADD) ; Short-branched-chain AD deficiency (SBCADD) ; Very long-chain AD deficiency (VLCADD) ; Long-chain 3-hydroxyacyl CoA dehydrogenase deficiency (LCHADD) ; Trifunctional protein deficiency (TFP); Carnitine palmitoyltransferase deficiency (CPT); Carnitine-acylcarnitine translocase deficiency (CACT); Systemic primary carnitine deficiency (CDSP)	Chronic granulomatous disease, including the following four diseases: X-linked CGD (gp91 phox CGD); p22phox deficiency (p22phox CGD); p47phox deficiency (p47phox CGD); p67phox deficiency (p67phox CGD)
GWAS		Apolipoprotein A1 levels ( 32203549) Coronary artery calcified atherosclerotic plaque score in type 2 diabetes ( 29221444) HDL cholesterol levels ( 32203549) Lipid metabolism phenotypes ( 22286219) Lipid traits (pleiotropy) (HIPO component 1) ( 30289880) Obesity-related traits ( 23251661) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Triglyceride levels ( 32154731 32203549) Urate levels ( 31578528)	Glycated hemoglobin levels ( 24647736) Hair color ( 26926045)
Interacting Genes		8 interacting genes: BCL2 CLIC1 CYBA HSPA5 KBTBD7 NPDC1 NR4A1 UBC	12 interacting genes: APPBP2 CPT1A CYBB MDFI NCF2 NCF4 NOX1 PSMA3 RAC1 RBPMS RCHY1 UPF2
Entrez ID		1374	1535
HPRD ID		02755	01989
Ensembl ID		ENSG00000110090	ENSG00000051523
Uniprot IDs		B2RAQ8 P50416 Q8WZ48	B4DT46 H3BNP7 P13498
PDB IDs		2LE3	1WLP 7U8G 7YXW 8GZ3 8KEI 8WEJ 8X2L
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Retinal Cell Programmed Cell Death Ubiquitin Protein Ligase Binding Regulation Of Mitochondrial Membrane Potential Negative Regulation Of Cellular PH Reduction Neural Nucleus Development Cellular Response To Glucose Starvation Protein Heterodimerization Activity Nuclear Membrane Response To Gamma Radiation Mitochondrion Smooth Muscle Hypertrophy Negative Regulation Of Glomerular Filtration By Angiotensin Regulation Of Protein Folding In Endoplasmic Reticulum Reactive Oxygen Species Metabolic Process CD8-positive, Alpha-beta T Cell Lineage Commitment BAD-BCL-2 Complex Channel Inhibitor Activity Endoplasmic Reticulum Membrane Positive Regulation Of Endothelial Cell Proliferation Cerebellum Structural Organization Negative Regulation Of Calcium Ion Transport Into Cytosol Response To Nutrient Levels Regulation Of Calcium Ion Transmembrane Transport Dendritic Cell Apoptotic Process Cochlear Nucleus Development Protein Ubiquitination Regulation Of Melanocyte Differentiation Response To Hormone Regulation Of Nitrogen Utilization Response To Peptide Regulation Of Retinal Cell Programmed Cell Death Response To Ionizing Radiation Response To Cytokine Positive Regulation Of Melanocyte Differentiation Immune System Development Positive Regulation Of Neuron Maturation Retinal Cell Programmed Cell Death Response To Corticosteroid Cellular Response To L-glutamine Positive Regulation Of Mucus Secretion Regulation Of Renal Output By Angiotensin Regulation Of Endothelial Cell Proliferation Detection Of Lipopolysaccharide Cellular Response To Corticotropin-releasing Hormone Stimulus Regulation Of ATF6-mediated Unfolded Protein Response Positive Regulation Of Cell Growth B Cell Lineage Commitment BH3 Domain Binding Positive Regulation Of Pigment Cell Differentiation Regulation Of Blood Volume By Renin-angiotensin	NADPH Oxidase Complex Respiratory Burst Superoxide Anion Generation Superoxide Metabolic Process Reactive Oxygen Species Metabolic Process Superoxide-generating NAD(P)H Oxidase Activity Oxidoreductase Activity, Acting On NAD(P)H, Oxygen As Acceptor Phagolysosome Superoxide-generating NADPH Oxidase Activity Superoxide-generating NADPH Oxidase Activator Activity NAD(P)H Oxidase H2O2-forming Activity Hydrogen Peroxide Metabolic Process Cytoplasm Animal Organ Regeneration Electron Transfer Activity
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